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Protein Arginine Methyltransferase 5 Proteins (PRMT5)

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Additionally we are shipping PRMT5 Antibodies (138) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat PRMT5 PRMT5 445443  
PRMT5 10419 O14744
PRMT5 27374 Q8CIG8
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Top PRMT5 Proteins at

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag,DYKDDDDK Tag 50 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Baculovirus Human DYKDDDDK Tag PRMT5 activity assay. HMT assay measuring the activity of Recombinant ... Recombinant PRMT5 protein gel. PRMT5 protein was run on a 10% SDS-PAGE... 20 μg Log in to see 1 to 2 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

PRMT5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , ,
Mouse (Murine)

Top referenced PRMT5 Proteins

  1. Human PRMT5 Protein expressed in Human Cells - ABIN2003914 : Rho, Choi, Seong, Cho, Kim, Im: Prmt5, which forms distinct homo-oligomers, is a member of the protein-arginine methyltransferase family. in The Journal of biological chemistry 2001 (PubMed)
    Show all 5 references for ABIN2003914

  2. Human PRMT5 Protein expressed in Wheat germ - ABIN1316333 : Kanamaluru, Xiao, Fang, Choi, Kim, Veenstra, Kemper: Arginine methylation by PRMT5 at a naturally occurring mutation site is critical for liver metabolic regulation by small heterodimer partner. in Molecular and cellular biology 2011 (PubMed)

More Proteins for Protein Arginine Methyltransferase 5 (PRMT5) Interaction Partners

Human Protein Arginine Methyltransferase 5 (PRMT5) interaction partners

  1. Increased PRMT5 activity enhanced acute myeloid leukemia (show BCL11A Proteins) growth.

  2. arginine residues within the third intracellular loop of the D2 dopamine receptor were methylated by protein arginine methyltransferase 5 (PRMT5)

  3. high nuclear expression of Protein arginine methyltransferase-5 is a potentially useful marker for estimating submucosal invasion of early colorectal carcinomas in endoscopically resected specimens

  4. Findings provide new evidence that PRMT5 plays an important role in CRC (show CALR Proteins) pathogenesis through epigenetically regulating arginine methylation of oncogenes such as eIF4E (show EIF4E Proteins) and FGFR3 (show FGFR3 Proteins).

  5. PRMT5-induced methylation prevented phosphorylation of SREBP1a on S430 by GSK3beta

  6. PRMT5 plays an important role in human hepatocellular carcinoma growth via the downregulation of beta-catenin (show CTNNB1 Proteins)

  7. Data show that the E3 ubiquitin ligase (show MUL1 Proteins) CHIP interacts with protein arginine methyltransferase-5 (PRMT5) both in vivo and in vitro.

  8. PRMT5 gene is silencing gene expression by histone arginine methylation in keratinocytes.

  9. PRMT5 co-localizes with RASSF1A (show RASSF1 Proteins) on stabilized microtubules.RASSF1A promotes the translocation of cytosolic PRMT5 to microtubules.

  10. UHRF1 (show UHRF1 Proteins) could form a complex with PRMT5 to contribute to the endometrial carcinogenesis.

Zebrafish Protein Arginine Methyltransferase 5 (PRMT5) interaction partners

  1. a combinatorial role of PRMT4/CARM1 (show CARM1 Proteins) and PRMT5 for proper myogenesis in zebrafish

Xenopus laevis Protein Arginine Methyltransferase 5 (PRMT5) interaction partners

  1. Data indicate that MEP50 (show WDR77 Proteins) WD repeat protein (show DCAF7 Proteins) is essential for methylation of histones H4 and H2A (show H2AFX Proteins) by PRMT5 arginine methyltransferase.

  2. data support a mechanism in which MEP50 (show WDR77 Proteins) binds substrate and stimulates PRMT5 activity modulated by substrate post-translational modifications

  3. Protein arginine methyltransferase Prmt5-Mep50 (show WDR77 Proteins) methylates histones H2A (show H2AFX Proteins) and H4 and the histone chaperone nucleoplasmin (show NPM1 Proteins) in Xenopus laevis eggs

Mouse (Murine) Protein Arginine Methyltransferase 5 (PRMT5) interaction partners

  1. Taken together, our data reveal a pathophysiologically relevant role for PRMT5 in MHC II transactivation in macrophages

  2. Prmt5 is required for germ cell survival during spermatogenesis in mice.

  3. Prmt5 controls proliferation of adult muscle stem cells by direct epigenetic silencing of the cell cycle inhibitor p21.

  4. Prmt5 plays critical roles in germ cell development that are required for germ cell survival during embryonic stages

  5. results demonstrate that PRMT5 plays distinct roles in the behavior of HSCs compared with HPCs and is essential for the maintenance of adult hematopoietic cells.

  6. PRMT5 regulates gene expression by promoting methylation of the Sm spliceosomal proteins, but is not required for primordial germ cell specification.

  7. PRMT5 controls symmetrical dimethylation on arginine-3 of histone H4 in mouse embryonic fibroblasts.

  8. PRMT5 knockdown in non-Hodgkin lymphoma cell lines and primary lymphoma cells leads to RBL2 (show RBL2 Proteins) derepression and RB1 (show RB1 Proteins) reactivation, which in turn inhibit PRC2 expression.

  9. PRMT5 is a master regulator of splicing in mammals

  10. type II protein arginine methyltransferase 5 has a role in the regulation of Circadian Per1 and CRY1 (show CRY1 Proteins) genes

Caenorhabditis elegans (C. elegans) Protein Arginine Methyltransferase 5 (PRMT5) interaction partners

  1. Analysis of prmt-5-deficient worms indicated that methylation promoted the dopamine-mediated modulation of chemosensory and locomotory behaviors through the DOP (show COPB2 Proteins)-3 receptor.

  2. data confirm that MEP50 (show WDR77 Proteins) plays a key role in substrate recognition and activates PRMT5 activity by increasing its affinity for protein substrates.

  3. the substrate specificity, processivity, and kinetic mechanism of bacterially expressed Caenorhabditis elegans PRMT5 (cPRMT5).

  4. analysis of structural insights into protein arginine symmetric dimethylation by PRMT5

  5. PRMT-5 represses CEP-1 transcriptional activity through CBP-1, which represents a novel regulatory mechanism of p53 (show TP53 Proteins)-dependent apoptosis.

PRMT5 Protein Profile

Protein Summary

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3)\; such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR\; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation. Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (By similarity). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation (By similarity). Methylates HOXA9 (By similarity).

Gene names and symbols associated with PRMT5

  • protein arginine methyltransferase 5 (PRMT5)
  • putative arginine N-methyltransferase, type II (PRMT5)
  • Skb1 family protein (prmt5)
  • protein arginine N-methyltransferase 5 (Prmt5)
  • prmt5 protein (prmt5)
  • protein arginine methyltransferase 5 (prmt5)
  • HMT1 hnRNP methyltransferase-like 5 (S. cerevisiae) (Hrmt1l5)
  • protein arginine methyltransferase 5 (Prmt5)
  • Protein PRMT-5 (prmt-5)
  • DDBDRAFT_0187422 protein
  • DDBDRAFT_0235403 protein
  • DDB_0187422 protein
  • DDB_0235403 protein
  • HRMT1L5 protein
  • hsl7 protein
  • IBP72 protein
  • Jbp1 protein
  • NV18830 protein
  • Prmt5 protein
  • si:zc14a17.2 protein
  • Skb1 protein
  • SKB1Hs protein
  • wu:fb95f10 protein
  • zgc:110669 protein

Protein level used designations for PRMT5

protein arginine methyltransferase 5 , protein arginine N-methyltransferase 5 , SKB1 homolog , shk1 kinase-binding protein 1 homolog , histone-arginine N-methyltransferase PRMT5 , putative arginine N-methyltransferase, type II , protein arginine methyltransferase , protein arginine N-methyltransferase 5-like , 72 kDa ICln-binding protein , HMT1 hnRNP methyltransferase-like 5 , jak-binding protein 1 , Jak-binding protein 1

100052729 Equus caballus
100583805 Nomascus leucogenys
100173581 Pongo abelii
452789 Pan troglodytes
712718 Macaca mulatta
5068851 Leishmania infantum JPCM5
8626071 Dictyostelium discoideum AX4
100024287 Monodelphis domestica
100115766 Nasonia vitripennis
100144380 Oryzias latipes
100145788 Xenopus (Silurana) tropicalis
100357415 Oryctolagus cuniculus
100473723 Ailuropoda melanoleuca
100555438 Anolis carolinensis
445443 Rattus norvegicus
10419 Homo sapiens
368664 Danio rerio
495515 Xenopus laevis
480242 Canis lupus familiaris
100294711 Sus scrofa
515594 Bos taurus
364382 Rattus norvegicus
27374 Mus musculus
175717 Caenorhabditis elegans
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