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Protein C (Inactivator of Coagulation Factors Va and VIIIa) Proteins (PROC)

PROC encodes a vitamin K-dependent plasma glycoprotein. Additionally we are shipping PROC Antibodies (36) and PROC Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PROC 25268 P31394
PROC 19123 P33587
PROC 5624 P04070
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Top PROC Proteins at antibodies-online.com

Showing 10 out of 20 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Mouse His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Goat His tag   1 mg Log in to see 56 to 66 Days
$2,352.17
Details
Yeast Cat His tag   1 mg Log in to see 56 to 66 Days
$2,352.17
Details
Yeast Horse His tag   1 mg Log in to see 56 to 66 Days
$2,352.17
Details
Yeast Macaca mulatta His tag   1 mg Log in to see 56 to 66 Days
$2,365.00
Details
Yeast Dog His tag   1 mg Log in to see 56 to 66 Days
$3,151.50
Details

PROC Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Mouse (Murine) ,

Human , , ,
,

Top referenced PROC Proteins

  1. Human PROC Protein expressed in Human Cells - ABIN2002308 : Hosac: Drotrecogin alfa (activated): the first FDA-approved treatment for severe sepsis. in Proceedings (Baylor University. Medical Center) 2005 (PubMed)

More Proteins for Protein C (Inactivator of Coagulation Factors Va and VIIIa) (PROC) Interaction Partners

Mouse (Murine) Protein C (Inactivator of Coagulation Factors Va and VIIIa) (PROC) interaction partners

  1. These findings reveal a novel biological function and mechanism of the protein C pathway in which protein S and the aPC (show APC Proteins)-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC (show APC Proteins) in the context of endotoxemia and infection

  2. activated PC-EPCR-PAR1 signaling promotes hematopoietic stem cell retention in bone marrow.

  3. impaired EPCR (show PROCR Proteins)/protein C-binding interactions not only result in procoagulant and proinflammatory effects, but also impact hematopoiesis

  4. SOD prevents thrombomodulin (show THBD Proteins) methionine oxidation, promotes protein C activation, and protects against arterial and venous thrombosis in mice.

  5. sPLA2 (show PLA2G2A Proteins)-V plays a thrombogenic role by impairing the ability of EPCR (show PROCR Proteins) to promote protein C activation.

  6. Data identify anticoagulant activated protein C as a "metaplastic molecule", capable of shifting the threshold of LTP (show SCP2 Proteins) towards further potentiation

  7. Histones regulate activated protein C formation in a manner similar to PF4 (show PF4 Proteins) and suggest heparinoids may be benificial in sepsis.

  8. EPCR (show PROCR Proteins) and APC (show APC Proteins) play a limited role in the host response during pulmonary tuberculosis.

  9. Inhibition of the anticoagulant function of activated protein C does not interfere with its protective role during Gram-negative pneumosepsis, suggesting a more prominent role for cytoprotective effects of APC (show APC Proteins) .

  10. RNA interference of Serpinc1 (show SERPINC1 Proteins) and/or Proc allows for evaluation of the function of these genes in vivo and provides a novel, controlled mouse model for spontaneous venous thrombosis.

Human Protein C (Inactivator of Coagulation Factors Va and VIIIa) (PROC) interaction partners

  1. Elevated levels of circulating microparticles can play a role in carriers of mild and severe inherited thrombophilia resulting from protein C deficiency.

  2. ApoER2 (show LRP8 Proteins) contributes cooperatively with endothelial cell protein C receptor (show PROCR Proteins) and protease activated receptor 1 (show F2R Proteins) to APC (show APC Proteins)-initiated endothelial antiapoptotic and barrier protective signaling.

  3. Results show that free activated protein C binds to membrane EPCR (show PROCR Proteins) in ovarian cancer cells inducing cell migration via MEK (show MAP2K1 Proteins)-ERK (show EPHB2 Proteins) and Rho-GTPase (show RACGAP1 Proteins) pathways. The cancer cells become highly aggressive, and secondary nodules develop because of fibrin inhibition.

  4. Low levels of protein C during pregnancy were not associated with adverse pregnancy outcome.

  5. Report activation of protein C and down-regulation of EPCR (show PROCR Proteins) in trophobolasts stimulated with TNF-alpha (show TNF Proteins).

  6. levels of protein C and soluble thrombomodulin (show THBD Proteins) in critically ill patients with acute kidney injury

  7. Data show the molecular model of the complex of activated protein C (APC (show APC Proteins)) with alphaVbeta3 integrin obtained by protein-protein docking approach.

  8. Protein C is activated during in vitro thrombolysis.

  9. Results provide evidence that APC (show APC Proteins) selectively inhibits proliferation and the inflammatory signaling pathways of rheumatoid synovial fibroblasts.

  10. High avidity anti-protein C antibodies by provide marker for a severe thrombotic phenotype in antiphospholipid syndrome.

Cow (Bovine) Protein C (Inactivator of Coagulation Factors Va and VIIIa) (PROC) interaction partners

  1. Activated protein c is a ghrelin (show GHRL Proteins) endopeptidase.

  2. Activated protein C(APC (show APC Proteins)) combined with protein S(PS) had significant antithrombotic effect. APC (show APC Proteins) combined with PS prolonged clotting time. Dependence on APC (show APC Proteins)-cofactor activity of PS for expression of anticoagulant activity by APC (show APC Proteins).

PROC Protein Profile

Protein Summary

This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.

Gene names and symbols associated with PROC

  • protein C (inactivator of coagulation factors Va and VIIIa), a (proca)
  • protein C (inactivator of coagulation factors Va and VIIIa) (PROC)
  • protein C (inactivator of coagulation factors Va and VIIIa) (proc)
  • protein C (inactivator of coagulation factors Va and VIIIa) (LOC100231143)
  • vitamin K-dependent protein C (CpipJ_CPIJ000393)
  • vitamin K-dependent protein C (CpipJ_CPIJ002754)
  • vitamin K-dependent protein C (CpipJ_CPIJ003717)
  • vitamin K-dependent protein C (CpipJ_CPIJ003718)
  • vitamin K-dependent protein C (CpipJ_CPIJ014440)
  • vitamin K-dependent protein C (CpipJ_CPIJ018032)
  • vitamin K-dependent protein C (CpipJ_CPIJ018737)
  • protein C (Proc)
  • APC protein
  • MGC64425 protein
  • PC protein
  • PROC protein
  • PROC1 protein
  • si:ch1073-188c16.3 protein
  • THPH3 protein
  • THPH4 protein
  • zgc:63987 protein

Protein level used designations for PROC

protein C , procl , anticoagulant protein C , vitamin K-dependent protein C , protein C (inactivator of coagulation factors Va and VIIIa) , vitamin K-dependent protein C-like , autoprothrombin IIA , blood coagulation factor XIV , inactivator of coagulation factors Va, VIII , catalytic region , protein C (precursor of vitamin K-dependent serine protease)

GENE ID SPECIES
393327 Danio rerio
395085 Gallus gallus
459593 Pan troglodytes
100302329 Ovis aries
380116 Xenopus laevis
548476 Xenopus (Silurana) tropicalis
100231143 Taeniopygia guttata
100448857 Pongo abelii
6031231 Culex quinquefasciatus
6033948 Culex quinquefasciatus
6035053 Culex quinquefasciatus
6035054 Culex quinquefasciatus
6047546 Culex quinquefasciatus
6052150 Culex quinquefasciatus
6052641 Culex quinquefasciatus
25268 Rattus norvegicus
19123 Mus musculus
5624 Homo sapiens
281428 Bos taurus
101096161 Felis catus
476104 Canis lupus familiaris
100051306 Equus caballus
396954 Sus scrofa
100009223 Oryctolagus cuniculus
699077 Macaca mulatta
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