anti-Protein C (Inactivator of Coagulation Factors Va and VIIIa) (PROC) Antibodies

PROC encodes a vitamin K-dependent plasma glycoprotein. Additionally we are shipping PROC Proteins (21) and PROC Kits (20) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PROC 25268 P31394
PROC 19123 P33587
PROC 5624 P04070
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Top anti-PROC Antibodies at antibodies-online.com

Showing 10 out of 32 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Horse Rabbit Un-conjugated IHC, WB WB Suggested Anti-PROC Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: MCF7 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-Protein C antibody, Western blotting Lane 1: JURKAT Cell Lysate Lane 2: CEM Cell Lysate Lane 3: SMMC Cell Lysate Lane 4: HELA Cell Lysate Anti-Protein C antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Confocal immunofluorescent analysis of PROC Antibody (Center) (ABIN657466) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western blot analysis on human plasma using anti-vitamin K-dependent protein C polyclonal antibody.        100 μL Log in to see 13 to 16 Days
$275.00
Details
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 2 to 3 Days
$343.75
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 16 Days
$323.13
Details
Mouse Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of ES-2 cell lines, using PROC antibody. 200 μL Log in to see 13 to 14 Days
$478.50
Details
Human Mouse Un-conjugated WB Western Blot analysis of PROC expression in transfected 293T cell line by PROC MaxPab polyclonal antibody.Lane 1: PROC transfected lysate(50.71 KDa).Lane 2: Non-transfected lysate. 50 μL Log in to see 11 to 12 Days
$430.00
Details
Human Mouse Un-conjugated IP, ELISA, WB PROC monoclonal antibody (M01), clone 3A10. Western Blot analysis of PROC expression in human liver. Immunoprecipitation of PROC transfected lysate using anti-PROC monoclonal antibody and Protein A Magnetic Bead , and immunoblotted with PROC MaxPab rabbit polyclonal antibody. 100 μg Log in to see 11 to 12 Days
$430.00
Details

PROC Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus)


Mouse (Murine)


Human
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Top referenced anti-PROC Antibodies

  1. Horse (Equine) Polyclonal PROC Primary Antibody for IHC, WB - ABIN2776947 : Russell, Wellman, Walley: Protein C rs2069912 C allele is associated with increased mortality from severe sepsis in North Americans of East Asian ancestry. in Human genetics 2008 (PubMed)

More Antibodies against PROC Interaction Partners

Mouse (Murine) Protein C (Inactivator of Coagulation Factors Va and VIIIa) (PROC) interaction partners

  1. loss of the convertase furin (show FURIN Antibodies) or PC5 (show PCSK5 Antibodies)/6 in hepatocytes results in a approximately 30% decrease in APC (show APC Antibodies) levels, with no significant contribution from PACE4 (show PCSK6 Antibodies). We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin (show F2 Antibodies) activation.

  2. APC (show APC Antibodies) modifies pulmonary fibrosis by limiting thrombin (show F2 Antibodies)-dependent macrophage recruitment.

  3. Small interfering RNA-mediated silencing of protein C in apolipoprotein E (show APOE Antibodies)-deficient mice creates a condition that allows the occurrence of spontaneous atherothrombosis.

  4. These findings reveal a novel biological function and mechanism of the protein C pathway in which protein S and the aPC (show APC Antibodies)-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC (show APC Antibodies) in the context of endotoxemia and infection

  5. activated PC-EPCR-PAR1 signaling promotes hematopoietic stem cell retention in bone marrow.

  6. impaired EPCR (show PROCR Antibodies)/protein C-binding interactions not only result in procoagulant and proinflammatory effects, but also impact hematopoiesis

  7. SOD prevents thrombomodulin (show THBD Antibodies) methionine oxidation, promotes protein C activation, and protects against arterial and venous thrombosis in mice.

  8. sPLA2 (show PLA2G2A Antibodies)-V plays a thrombogenic role by impairing the ability of EPCR (show PROCR Antibodies) to promote protein C activation.

  9. Data identify anticoagulant activated protein C as a "metaplastic molecule", capable of shifting the threshold of LTP (show SCP2 Antibodies) towards further potentiation

  10. Histones regulate activated protein C formation in a manner similar to PF4 (show PF4 Antibodies) and suggest heparinoids may be benificial in sepsis.

Human Protein C (Inactivator of Coagulation Factors Va and VIIIa) (PROC) interaction partners

  1. loss of the convertase furin (show FURIN Antibodies) or PC5 (show PCSK5 Antibodies)/6 in hepatocytes results in a approximately 30% decrease in APC (show APC Antibodies) levels, with no significant contribution from PACE4 (show PCSK6 Antibodies). We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin (show F2 Antibodies) activation.

  2. Both probands had hereditary protein C deficiencies, for which their parents were all carriers.

  3. Variants influencing circulating protein C levels in the CELSR2 (show CELSR2 Antibodies)-PSRC1 (show PSRC1 Antibodies)-SORT1 (show SORT1 Antibodies) region may indicate a novel genetic link between lipoprotein metabolism and hemostasis.

  4. These findings suggest that the anti-inflammatory function of APC (show APC Antibodies) at therapeutic concentrations may include the inhibition of NETosis in an EPCR (show PROCR Antibodies)-, PAR3 (show F2RL2 Antibodies)-, and Mac-1 (show ITGAM Antibodies)-dependent manner, providing additional mechanistic insight into the diverse functions of neutrophils and APC (show APC Antibodies) in disease states including sepsis.

  5. Collectively, these data depict a pivotal role for AMPK (show PRKAA1 Antibodies) signaling in inhibiting ER stress responses via the activation of APC (show APC Antibodies) during MGO-induced cardiomyocyte apoptosis. Thus, APC (show APC Antibodies) may be a potential novel therapeutic target for the management of diabetic cardiovascular complications such as diabetic cardiomyopathy.

  6. An activation-resistant homozygous protein C R229W mutation was linked to perinatal intracranial bleeding and delayed onset of thrombosis.

  7. Structural and functional studies of novel heterozygous mutations in the PROC gene confirmed that the mutations were pathogenetic in two Chinese families with types I and II protein C deficiency.

  8. Study detected a statistically significant positive correlation between expanded disability status scale scores and thrombomodulin (show THBD Antibodies) levels (p<0.01) and a 10% positive correlation between expanded disability status scale scores and APC (show APC Antibodies) levels in multiple sclerosis patients

  9. Low protein C expression is associated with diabetes mellitus.

  10. Genetic variants in thrombomodulin (show THBD Antibodies) and endothelial protein C receptor (show PROCR Antibodies) genes are additively associated with mortality in acute respiratory distress syndrome in European ancestry

Cow (Bovine) Protein C (Inactivator of Coagulation Factors Va and VIIIa) (PROC) interaction partners

  1. Activated protein c is a ghrelin (show GHRL Antibodies) endopeptidase.

  2. Activated protein C(APC (show APC Antibodies)) combined with protein S(PS) had significant antithrombotic effect. APC (show APC Antibodies) combined with PS prolonged clotting time. Dependence on APC (show APC Antibodies)-cofactor activity of PS for expression of anticoagulant activity by APC (show APC Antibodies).

PROC Antigen Profile

Protein Summary

This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.

Gene names and symbols associated with PROC

  • protein C (inactivator of coagulation factors Va and VIIIa), a (proca) antibody
  • protein C (inactivator of coagulation factors Va and VIIIa) (PROC) antibody
  • protein C (inactivator of coagulation factors Va and VIIIa) (proc) antibody
  • protein C (inactivator of coagulation factors Va and VIIIa) (LOC100231143) antibody
  • vitamin K-dependent protein C (CpipJ_CPIJ000393) antibody
  • vitamin K-dependent protein C (CpipJ_CPIJ002754) antibody
  • vitamin K-dependent protein C (CpipJ_CPIJ003717) antibody
  • vitamin K-dependent protein C (CpipJ_CPIJ003718) antibody
  • vitamin K-dependent protein C (CpipJ_CPIJ014440) antibody
  • vitamin K-dependent protein C (CpipJ_CPIJ018032) antibody
  • vitamin K-dependent protein C (CpipJ_CPIJ018737) antibody
  • protein C (Proc) antibody
  • APC antibody
  • MGC64425 antibody
  • PC antibody
  • PROC antibody
  • PROC1 antibody
  • si:ch1073-188c16.3 antibody
  • THPH3 antibody
  • THPH4 antibody
  • zgc:63987 antibody

Protein level used designations for PROC

protein C , procl , anticoagulant protein C , vitamin K-dependent protein C , protein C (inactivator of coagulation factors Va and VIIIa) , vitamin K-dependent protein C-like , autoprothrombin IIA , blood coagulation factor XIV , inactivator of coagulation factors Va, VIII , catalytic region , protein C (precursor of vitamin K-dependent serine protease)

GENE ID SPECIES
393327 Danio rerio
395085 Gallus gallus
459593 Pan troglodytes
100302329 Ovis aries
380116 Xenopus laevis
548476 Xenopus (Silurana) tropicalis
100231143 Taeniopygia guttata
100448857 Pongo abelii
6031231 Culex quinquefasciatus
6033948 Culex quinquefasciatus
6035053 Culex quinquefasciatus
6035054 Culex quinquefasciatus
6047546 Culex quinquefasciatus
6052150 Culex quinquefasciatus
6052641 Culex quinquefasciatus
25268 Rattus norvegicus
19123 Mus musculus
5624 Homo sapiens
281428 Bos taurus
101096161 Felis catus
476104 Canis lupus familiaris
100051306 Equus caballus
396954 Sus scrofa
100009223 Oryctolagus cuniculus
699077 Macaca mulatta
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