Protein C (Inactivator of Coagulation Factors Va and VIIIa) Proteins (PROC)

PROC encodes a vitamin K-dependent plasma glycoprotein. Additionally we are shipping PROC Antibodies (33) and PROC Kits (22) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PROC 25268 P31394
PROC 19123 P33587
PROC 5624 P04070
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Top PROC Proteins at antibodies-online.com

Showing 10 out of 21 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
HOST_Human Cells Mouse His tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Mammalian Cells Human His tag   50 μg Log in to see 4 Days
$548.63
Details
HOST_Human Human His tag   10 μg Log in to see 15 to 16 Days
$300.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Yeast Goat His tag   1 mg Log in to see 60 to 71 Days
$2,352.17
Details
Yeast Horse His tag   1 mg Log in to see 60 to 71 Days
$2,352.17
Details
Yeast Cat His tag   1 mg Log in to see 60 to 71 Days
$2,352.17
Details

PROC Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Mouse (Murine) ,

Human , , , ,
,

Top referenced PROC Proteins

  1. Human PROC Protein expressed in Human Cells - ABIN2002308 : Hosac: Drotrecogin alfa (activated): the first FDA-approved treatment for severe sepsis. in Proceedings (Baylor University. Medical Center) 2005 (PubMed)

More Proteins for Protein C (Inactivator of Coagulation Factors Va and VIIIa) (PROC) Interaction Partners

Mouse (Murine) Protein C (Inactivator of Coagulation Factors Va and VIIIa) (PROC) interaction partners

  1. loss of the convertase furin (show FURIN Proteins) or PC5 (show PCSK5 Proteins)/6 in hepatocytes results in a approximately 30% decrease in APC (show APC Proteins) levels, with no significant contribution from PACE4. We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin (show F2 Proteins) activation.

  2. APC (show APC Proteins) modifies pulmonary fibrosis by limiting thrombin (show F2 Proteins)-dependent macrophage recruitment.

  3. Small interfering RNA-mediated silencing of protein C in apolipoprotein E (show APOE Proteins)-deficient mice creates a condition that allows the occurrence of spontaneous atherothrombosis.

  4. These findings reveal a novel biological function and mechanism of the protein C pathway in which protein S and the aPC (show APC Proteins)-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC (show APC Proteins) in the context of endotoxemia and infection

  5. activated PC-EPCR-PAR1 signaling promotes hematopoietic stem cell retention in bone marrow.

  6. impaired EPCR (show PROCR Proteins)/protein C-binding interactions not only result in procoagulant and proinflammatory effects, but also impact hematopoiesis

  7. SOD prevents thrombomodulin (show THBD Proteins) methionine oxidation, promotes protein C activation, and protects against arterial and venous thrombosis in mice.

  8. sPLA2 (show PLA2G2A Proteins)-V plays a thrombogenic role by impairing the ability of EPCR (show PROCR Proteins) to promote protein C activation.

  9. Data identify anticoagulant activated protein C as a "metaplastic molecule", capable of shifting the threshold of LTP (show SCP2 Proteins) towards further potentiation

  10. Histones regulate activated protein C formation in a manner similar to PF4 (show PF4 Proteins) and suggest heparinoids may be benificial in sepsis.

Human Protein C (Inactivator of Coagulation Factors Va and VIIIa) (PROC) interaction partners

  1. A novel mutation of A309V in PROC was determined in a family of two patients with late onset protein C deficiency

  2. loss of the convertase furin (show FURIN Proteins) or PC5 (show PCSK5 Proteins)/6 in hepatocytes results in a approximately 30% decrease in APC (show APC Proteins) levels, with no significant contribution from PACE4. We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin (show F2 Proteins) activation.

  3. Both probands had hereditary protein C deficiencies, for which their parents were all carriers.

  4. Variants influencing circulating protein C levels in the CELSR2 (show CELSR2 Proteins)-PSRC1 (show PSRC1 Proteins)-SORT1 (show SORT1 Proteins) region may indicate a novel genetic link between lipoprotein metabolism and hemostasis.

  5. These findings suggest that the anti-inflammatory function of APC (show APC Proteins) at therapeutic concentrations may include the inhibition of NETosis in an EPCR (show PROCR Proteins)-, PAR3 (show F2RL2 Proteins)-, and Mac-1 (show ITGAM Proteins)-dependent manner, providing additional mechanistic insight into the diverse functions of neutrophils and APC (show APC Proteins) in disease states including sepsis.

  6. Collectively, these data depict a pivotal role for AMPK (show PRKAA1 Proteins) signaling in inhibiting ER stress responses via the activation of APC (show APC Proteins) during MGO-induced cardiomyocyte apoptosis. Thus, APC (show APC Proteins) may be a potential novel therapeutic target for the management of diabetic cardiovascular complications such as diabetic cardiomyopathy.

  7. An activation-resistant homozygous protein C R229W mutation was linked to perinatal intracranial bleeding and delayed onset of thrombosis.

  8. Structural and functional studies of novel heterozygous mutations in the PROC gene confirmed that the mutations were pathogenetic in two Chinese families with types I and II protein C deficiency.

  9. Study detected a statistically significant positive correlation between expanded disability status scale scores and thrombomodulin (show THBD Proteins) levels (p<0.01) and a 10% positive correlation between expanded disability status scale scores and APC (show APC Proteins) levels in multiple sclerosis patients

  10. Low protein C expression is associated with diabetes mellitus.

Cow (Bovine) Protein C (Inactivator of Coagulation Factors Va and VIIIa) (PROC) interaction partners

  1. Activated protein c is a ghrelin (show GHRL Proteins) endopeptidase.

  2. Activated protein C(APC (show APC Proteins)) combined with protein S(PS) had significant antithrombotic effect. APC (show APC Proteins) combined with PS prolonged clotting time. Dependence on APC (show APC Proteins)-cofactor activity of PS for expression of anticoagulant activity by APC (show APC Proteins).

PROC Protein Profile

Protein Summary

This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.

Gene names and symbols associated with PROC

  • protein C (inactivator of coagulation factors Va and VIIIa), a (proca)
  • protein C (inactivator of coagulation factors Va and VIIIa) (PROC)
  • protein C (inactivator of coagulation factors Va and VIIIa) (proc)
  • protein C (inactivator of coagulation factors Va and VIIIa) (LOC100231143)
  • vitamin K-dependent protein C (CpipJ_CPIJ000393)
  • vitamin K-dependent protein C (CpipJ_CPIJ002754)
  • vitamin K-dependent protein C (CpipJ_CPIJ003717)
  • vitamin K-dependent protein C (CpipJ_CPIJ003718)
  • vitamin K-dependent protein C (CpipJ_CPIJ014440)
  • vitamin K-dependent protein C (CpipJ_CPIJ018032)
  • vitamin K-dependent protein C (CpipJ_CPIJ018737)
  • protein C (Proc)
  • APC protein
  • MGC64425 protein
  • PC protein
  • PROC protein
  • PROC1 protein
  • si:ch1073-188c16.3 protein
  • THPH3 protein
  • THPH4 protein
  • zgc:63987 protein

Protein level used designations for PROC

protein C , procl , anticoagulant protein C , vitamin K-dependent protein C , protein C (inactivator of coagulation factors Va and VIIIa) , vitamin K-dependent protein C-like , autoprothrombin IIA , blood coagulation factor XIV , inactivator of coagulation factors Va, VIII , catalytic region , protein C (precursor of vitamin K-dependent serine protease)

GENE ID SPECIES
393327 Danio rerio
395085 Gallus gallus
459593 Pan troglodytes
100302329 Ovis aries
380116 Xenopus laevis
548476 Xenopus (Silurana) tropicalis
100231143 Taeniopygia guttata
100448857 Pongo abelii
6031231 Culex quinquefasciatus
6033948 Culex quinquefasciatus
6035053 Culex quinquefasciatus
6035054 Culex quinquefasciatus
6047546 Culex quinquefasciatus
6052150 Culex quinquefasciatus
6052641 Culex quinquefasciatus
25268 Rattus norvegicus
19123 Mus musculus
5624 Homo sapiens
281428 Bos taurus
101096161 Felis catus
476104 Canis lupus familiaris
100051306 Equus caballus
396954 Sus scrofa
100009223 Oryctolagus cuniculus
699077 Macaca mulatta
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