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The protein encoded by PROCR is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. Additionally we are shipping PROCR Antibodies (173) and PROCR Kits (57) and many more products for this protein.
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Human PROCR Protein expressed in Wheat germ - ABIN1316360
Fink, Busch, Bourgeois, Schwarz, Wolf, Zirlik, Peter, Bode, von Zur Muhlen: Mac-1 directly binds to the endothelial protein C-receptor: a link between the protein C anticoagulant pathway and inflammation? in PLoS ONE 2013
Show all 3 Pubmed References
EPCR occupancy recruits G-protein coupled receptor kinase 5 (show GRK5 Proteins), thereby inducing beta-arrestin-2 (show ARRB2 Proteins) biased PAR1 (show MARK2 Proteins) signaling by both APC (show APC Proteins) and thrombin (show F2 Proteins). In
EPCR polymorphisms may be associated with increased risk of sepsis, but this has no effect on the release of soluble EPCR in patients with sepsis.
Elevated endothelium-related mediators (vWF (show VWF Proteins), E-selectin (show SELE Proteins) and EPCR) appear to participate in the development of pancreatic necrosis and may be a potential indicator of overall prognosis.
The results showed that AS-IV could significantly inhibit PMA-induced EPCR shedding.
CORM-2 protects human umbilical vein endothelial cells from lipopolysaccharide-induced injury, by way of suppressing NF-kappaB (show NFKB1 Proteins) activity, which downregulates TM and EPCR mRNAs. It also decreases MMP-2 (show MMP2 Proteins) expression and prevents the shedding of TM and EPCR from the surface of endothelial cells, so as to preserve their protective effect.
This study shows that ICAM-1 (show ICAM1 Proteins) is a coreceptor for a subset of EPCR-binding Plasmodium falciparum parasites and provides the first evidence of how EPCR and ICAM-1 (show ICAM1 Proteins) interact to mediate parasite binding to both resting and TNF-alpha (show TNF Proteins)-activated primary brain and lung endothelial cells.
This study demonstrates that impaired EPCR function can be detected by thrombin (show F2 Proteins) generation and clot (show TXNDC17 Proteins) lysis assays on cells expressing thrombomodulin (show THBD Proteins) and EPCR. Deficiency in EPCR has procoagulant effects that lead to a delay in clot (show TXNDC17 Proteins) lysis.
Observations that binding of P. falciparum erythrocyte membrane protein 1 to EPCR results in an acquired functional protein C system deficiency support the new paradigm that EPCR plays a central role in the pathogenesis of severe malaria. [review]
data suggest that either the lack of the protective EPCR 4678C allele or the presence of EPCR 4600G allele may be associated with earlier development of thrombosis.
These data suggest that 6936A/G polymorphism is a risk factor for deep venous thrombosis and is associated with elevated plasma levels of soluble EPCR, while 4678G/C polymorphism plays a role in protection against deep venous thrombosis.
PROCR thus does not globally inhibit Th17 responses but could be targeted to selectively inhibit proinflammatory Th17 cells.
Thrombin (show F2 Proteins)-PAR1 (show F2R Proteins) signaling, via nitric oxide and EPCR, promotes hematopoietic stem cell (HSC (show FUT1 Proteins)) mobilization. aPC (show APC Proteins)-EPCR-PAR1 (show F2R Proteins) signaling promotes HSC (show FUT1 Proteins) retention in bone marrow.
impaired EPCR/protein C (show PROC Proteins)-binding interactions not only result in procoagulant and proinflammatory effects, but also impact hematopoiesis
sPLA2 (show PLA2G2A Proteins)-V plays a thrombogenic role by impairing the ability of EPCR to promote protein C (show PROC Proteins) activation.
HSCs appear to maintain expression of CD201 after hematopoietic injury when Kit expression is downregulated.
The protein C (show PROC Proteins) receptor (ProcR; EPCR) was required for the normal in vivo and in vitro induction of lipopolysaccharide (LPS (show TLR4 Proteins))-regulated gene expression.
Data indicate that endothelial protein C receptor (EPCR) binding enhances FVIIa hemostatic activity in vivo.
protein C (show PROC Proteins) receptor (Procr), a novel Wnt (show WNT2 Proteins) target in the mammary gland, marks a unique population of multipotent mouse mammary stem cells
FVIIa binding to EPCR leads to a barrier protective effect in vivo
Piperlonguminine might have potential as an anti-sEPCR shedding reagent against sepsis-mediated EPCR shedding.
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.
protein C receptor, endothelial (EPCR)
, APC receptor
, CD201 antigen
, activated protein C receptor
, cell cycle, centrosome-associated protein
, endothelial protein C receptor
, endothelial cell protein C receptor
, CD antigen CD201
, centrosomal protein CCD41
, endothelial cell protein C/activated protein C