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The protein encoded by PICK1 contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). Additionally we are shipping PICK1 Kits (24) and PICK1 Proteins (10) and many more products for this protein.
Showing 10 out of 119 products:
Mouse (Murine) Polyclonal PICK1 Primary Antibody for ICC, IF - ABIN449250
Bassan, Liu, Madsen, Armsen, Zhou, Desilva, Chen, Paradise, Brasch, Staudinger, Gether, Irwin, Rosenberg: Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1. in The European journal of neuroscience 2008
Show all 4 references for ABIN449250
Mouse (Murine) Polyclonal PICK1 Primary Antibody for ELISA, WB - ABIN188575
Xu, Sun, Gibson, Henkemeyer: A dual shaping mechanism for postsynaptic ephrin-B3 as a receptor that sculpts dendrites and synapses. in Nature neuroscience 2011
Show all 2 references for ABIN188575
Dog (Canine) Polyclonal PICK1 Primary Antibody for EIA, WB - ABIN782997
Steinberg, Takamiya, Shen, Xia, Rubio, Yu, Jin, Thomas, Linden, Huganir: Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression. in Neuron 2006
Human Polyclonal PICK1 Primary Antibody for WB - ABIN391109
Xue, Zhang, Chen, Lin, Shi: PDZ protein mediated activity-dependent LTP/LTD developmental switch at rat retinocollicular synapses. in American journal of physiology. Cell physiology 2010
Mouse (Murine) Polyclonal PICK1 Primary Antibody for ICC, IF - ABIN189737
Sakamoto, Seiki: Mint3 enhances the activity of hypoxia-inducible factor-1 (HIF-1) in macrophages by suppressing the activity of factor inhibiting HIF-1. in The Journal of biological chemistry 2009
a dual role of PICK1 in regulating macrophage polarization
This study demonstrated that d-serine provent the behavioral deficits in adult Pick1 knockout mice.
PICK1 is an important regulator of P2Y6R (show P2RY6 Antibodies) expression and microglial phagocytosis.
knocking-out PICK1 gene casts the neuroprotection effect by reducing ASICs current and the calcium transients in OGD (show FGFR1 Antibodies)-Rep neuronal cells
ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis.
results indicate that PICK1 is a crucial regulator in glutathione homeostasis and may play important roles in oxidative stress.
In cultured neurons, PICK1 deletion increases surface AMPARs and blocks Abeta42-induced reduction in surface GluA2 (show GRIA2 Antibodies).
This study demonstrated that PICK1 functions in vesicle biogenesis and is necessary to maintain normal vesicle numbers and size.
C-terminal domain of ICA69 (show ICA1 Antibodies) interacts with PICK1 and acts on trafficking of PICK1-PKCalpha (show PKCa Antibodies) complex and cerebellar plasticity.
we found that PICK1's expression in testis rescued the spermatogenic abnormalities and male infertility in Pick1 knockout mice. Our results indicate that the infertility is caused by the lack of PICK1 in the testis rather than in other organs.
We propose that PICK1 negatively regulates neoplastic infiltration of astrocytic tumors and that manipulation of PICK1 is an attractive possibility for therapeutic intervention
PICK1 domain ACT links PICK1-associated vesicles to a motility factor, likely myosin, but, contrary to previous reports, PICK1 neither binds nor inhibits Arp2 (show ACTR2 Antibodies)/3 complex.
Unlike accessory domains in other BAR domain proteins, the positioning of the PDZ domains is flexible, enabling PICK1 to perform long-range, dynamic scaffolding of membrane-associated proteins.
Data indicate three principal binding modes can account for protein interacting with C-kinase 1 (PICK1) PDZ domains binding specificity.
PICK1 promotes Ago2 (show EIF2C2 Antibodies) localization at endosomal compartments in neuronal dendrites and inhibits Ago2 (show EIF2C2 Antibodies) function in translational repression following neuronal stimulation.
These data indicate that Pick1 is involved in regulating the cell-cell junction in epithelial cells.
Family-based association study failed to observe a statistically significant association for any of the genotyped SNPs in the PICK1 gene and attention-deficit hyperactivity disorder.
PICK1 increases caveolin-mediated endocytosis, ubiquitination and degradation of TGF-beta type I receptor (show TGFBR1 Antibodies).
The binding affinities of all major PICK1 interacting proteins are reported and the effects of PICK1 mutations on these interactions are described.
The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.
, protein kinase C, alpha binding protein
, protein kinase C-alpha-binding protein
, protein that interacts with C kinase 1
, protein interacting with C kinase 1