Protein Interacting With Protein Kinase C, alpha 1 Proteins (PICK1)

The protein encoded by PICK1 contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). Additionally we are shipping PICK1 Antibodies (139) and PICK1 Kits (27) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PICK1 9463 Q9NRD5
PICK1 18693  
PICK1 84591 Q9EP80
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Top PICK1 Proteins at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 60 to 71 Days
$3,153.33
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,157.00
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$3,160.67
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$736.00
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human GST tag   50 μg Log in to see 11 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days
$941.88
Details

PICK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus)

More Proteins for Protein Interacting With Protein Kinase C, alpha 1 (PICK1) Interaction Partners

Mouse (Murine) Protein Interacting With Protein Kinase C, alpha 1 (PICK1) interaction partners

  1. Ca(2 (show CA2 Proteins)+) influx through ASIC1 (show ACCN2 Proteins) mediates chronic hypoxia and ET-1 (show EDN1 Proteins)-induced NFATc3 (show NFATC3 Proteins) nuclear import and 2) the scaffolding protein PICK1 is necessary for NFATc3 (show NFATC3 Proteins) nuclear import.

  2. a dual role of PICK1 in regulating macrophage polarization

  3. This study demonstrated that d-serine provent the behavioral deficits in adult Pick1 knockout mice.

  4. PICK1 is an important regulator of P2Y6R (show P2RY6 Proteins) expression and microglial phagocytosis.

  5. knocking-out PICK1 gene casts the neuroprotection effect by reducing ASICs current and the calcium transients in OGD (show FGFR1 Proteins)-Rep neuronal cells

  6. ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis.

  7. results indicate that PICK1 is a crucial regulator in glutathione homeostasis and may play important roles in oxidative stress.

  8. In cultured neurons, PICK1 deletion increases surface AMPARs and blocks Abeta42-induced reduction in surface GluA2 (show GRIA2 Proteins).

  9. This study demonstrated that PICK1 functions in vesicle biogenesis and is necessary to maintain normal vesicle numbers and size.

  10. C-terminal domain of ICA69 (show ICA1 Proteins) interacts with PICK1 and acts on trafficking of PICK1-PKCalpha (show PKCa Proteins) complex and cerebellar plasticity.

Human Protein Interacting With Protein Kinase C, alpha 1 (PICK1) interaction partners

  1. Our results demonstrate that downregulation of PICK1 elicited by miR (show MLXIP Proteins)-210-3p overexpression activates the TGF-b pathway, which further promotes bone metastasis in PCa (show FLVCR1 Proteins), indicating that the miR (show MLXIP Proteins)- 210-3p/PICK1/TGF-b signalling axis plays an important role in PCa (show FLVCR1 Proteins) bone metastasis.

  2. This study defines a novel mechanism whereby elevated [Ca(2 (show CA2 Proteins)+)] induced by NMDA receptor activation modulates Ago2 (show EIF2C2 Proteins) and miRNA activity via PICK1. Our work suggests a Ca(2 (show CA2 Proteins)+)-dependent process to regulate miRNA activity in neurons in response to the induction of long-term depression.

  3. We propose that PICK1 negatively regulates neoplastic infiltration of astrocytic tumors and that manipulation of PICK1 is an attractive possibility for therapeutic intervention

  4. PICK1 domain ACT links PICK1-associated vesicles to a motility factor, likely myosin, but, contrary to previous reports, PICK1 neither binds nor inhibits Arp2 (show ACTR2 Proteins)/3 complex.

  5. Unlike accessory domains in other BAR domain proteins, the positioning of the PDZ domains is flexible, enabling PICK1 to perform long-range, dynamic scaffolding of membrane-associated proteins.

  6. Data indicate three principal binding modes can account for protein interacting with C-kinase 1 (PICK1) PDZ domains binding specificity.

  7. PICK1 promotes Ago2 (show EIF2C2 Proteins) localization at endosomal compartments in neuronal dendrites and inhibits Ago2 (show EIF2C2 Proteins) function in translational repression following neuronal stimulation.

  8. These data indicate that Pick1 is involved in regulating the cell-cell junction in epithelial cells.

  9. C-terminal domain of ICA69 (show ICA1 Proteins) interacts with PICK1 and acts on trafficking of PICK1-PKCalpha (show PKCa Proteins) complex and cerebellar plasticity.

  10. Family-based association study failed to observe a statistically significant association for any of the genotyped SNPs in the PICK1 gene and attention-deficit hyperactivity disorder.

PICK1 Protein Profile

Protein Summary

The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with PICK1

  • protein interacting with PRKCA 1 (PICK1)
  • protein interacting with C kinase 1 (Pick1)
  • protein interacting with PRKCA 1 (Pick1)
  • protein interacting with PRKCA 1 (pick1)
  • DKFZp470L2127 protein
  • MGC131295 protein
  • PICK protein
  • PICK1 protein
  • prkcabp protein

Protein level used designations for PICK1

PRKCA-binding protein , protein interacting with C kinase 1 , protein kinase C-alpha-binding protein , protein kinase C, alpha binding protein , protein that interacts with C kinase 1 , protein interacting with PRKCA 1

GENE ID SPECIES
9463 Homo sapiens
18693 Mus musculus
84591 Rattus norvegicus
418030 Gallus gallus
533737 Bos taurus
610191 Canis lupus familiaris
734086 Xenopus (Silurana) tropicalis
735226 Xenopus laevis
100171712 Pongo abelii
100055023 Equus caballus
100158107 Sus scrofa
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