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Protein Kinase, CGMP-Dependent, Type I Proteins (PRKG1)

Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). Additionally we are shipping Protein Kinase, CGMP-Dependent, Type I Antibodies (64) and Protein Kinase, CGMP-Dependent, Type I Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PRKG1 54286  
PRKG1 5592 Q13976
PRKG1 19091 P0C605
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Top Protein Kinase, CGMP-Dependent, Type I Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
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HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PRKG1 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)
Human , , ,
,
Mouse (Murine)

More Proteins for Protein Kinase, CGMP-Dependent, Type I (PRKG1) Interaction Partners

Human Protein Kinase, CGMP-Dependent, Type I (PRKG1) interaction partners

  1. cAMP is a partial agonist for PKG, and we elucidate the mechanism for cAMP partial agonism through the comparative NMR analysis of the apo (show C9orf3 Proteins), cGMP-, and cAMP-bound forms of the PKG cyclic nucleotide-binding domain B.

  2. Protein kinase G has a role in regulating production of H2S, which governs oxygen sensing

  3. The C42-C42' disulfide bond dramatically stabilizes PRKG1.

  4. Study of genetic heterogeneity in systemic lupus erythematosus, the top associations in European ancestry were protein kinase (show CDK7 Proteins), cyclic GMP (show NT5C2 Proteins)-dependent, type I (PRKG1) rs7897633 (P(Meta) = 2.75 x 10(-8)) and purine nucleoside phosphorylase (PNP (show NP Proteins)) rs1049564 (P(Meta) = 1.24 x 10(-7)).

  5. Expression levels of miR (show MLXIP Proteins)-517a-3p and its target mRNA PRKG1 were inversely correlated in NK cells before and after obstetric delivery.

  6. miR (show MLXIP Proteins)-20a expression is up-regulated in response to hypoxia in both mouse and human pulmonary arterial smooth muscle cells

  7. Data show that functional cGMP/protein kinase G type 1 (PKG1) is expressed in pancreatic adenocarcinoma cells.

  8. These findings characterize PKG as a novel regulator of AR-mediated transcription by enhancing AR cofactor p44/WDR77's function.

  9. Neutron diffraction reveals hydrogen bonds critical for cGMP-selective activation: insights for cGMP-dependent protein kinase agonist design.

  10. Leucine296 and Arginine297 are key residues of PKG I that mediate cGMP selectivity.

Cow (Bovine) Protein Kinase, CGMP-Dependent, Type I (PRKG1) interaction partners

  1. NADPH (show FDXR Proteins) regulation of PKG1-alpha dimerization may contribute to vascular responses to hypoxia that are associated with changes in NADPH (show FDXR Proteins) redox.

  2. The data suggest that PKG-I expression is subjected to post-transcriptional regulation in VSMC through the 3'UTR of its mRNA.

  3. Report roles for redox mechanisms controlling protein kinase G in pulmonary and coronary artery responses to hypoxia.

  4. Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication

  5. purified cGMP kinase signaling complex contained alpha-actin (show ACTA2 Proteins), calponin H1, and phospholamban (show PLN Proteins)

  6. studies suggest that cross-activation of PKA in response to iNOS expression by inflammatory mediators downregulates cGMP-dependent protein kinase expression in bovine aortic vascular smooth muscle cells

  7. Demonstrate a novel PKG-dependent pathway by which the Rac1/Pak1 (show PAK1 Proteins) pathway is activated.

  8. cGMP-dependent protein kinase expression is regulated by soluble guanylyl cyclase in vascular smooth muscle cells

  9. cGMP-dependent protein kinase (show CDK7 Proteins) Ibeta binds to TFII-I (show GTF2I Proteins) and IRAG (show MRVI1 Proteins) through a common interaction motif

  10. cGMP binding destabilizes the N-terminus of cGMP-dependent protein kinase I alpha isozyme at the hinge region, centered around residue 77, while the C-terminus is protected from degradation.

Mouse (Murine) Protein Kinase, CGMP-Dependent, Type I (PRKG1) interaction partners

  1. Protein kinase G has a role in regulating production of H2S, which governs oxygen sensing

  2. cGMP/protein kinase (show CDK7 Proteins) G signaling suppresses Itpr1 (show ITPR1 Proteins) phosphorylation and promotes endoplasmic reticulum stress in photoreceptors of Cnga3 (show CNGA3 Proteins)-deficient mice.

  3. Data show that cGMP-dependent kinase (cGK-Ialpha) knockdown partially rescued TNF-alpha (show TNF Proteins)-induced decrease in 42-kDa cGMP-dependent protein kinase-anchoring protein (GKAP42 (show GKAP1 Proteins)) and impairment of insulin (show INS Proteins) signals.

  4. miR (show MLXIP Proteins)-20a expression is up-regulated in response to hypoxia in both mouse and human pulmonary arterial smooth muscle cells

  5. These findings characterize PKG as a novel regulator of AR-mediated transcription by enhancing AR cofactor p44/WDR77's function.

  6. A functional leucine zipper domain in PKG-1alpha is essential for maintenance of a low pulmonary vascular tone in normoxia.

  7. For the initial phase of angiotenin II-induced cardiac hypertrophy, lack of cardiomyocyte cGKI activity does not worsen hypertrophic growth.

  8. the key role of PKG-I in transforming growth factor beta1 induction by like weak inducer of apoptosis in kidney cells

  9. cGKI and Trpc1,3,6 channels are not functionally coupled in vascular smooth cell.

  10. Increasing PKG activity ameliorates renal fibrosis in part through regulation of macrophage and tubular cell function, leading to reduced TGF-beta (show TGFB1 Proteins)-induced fibrosis.

Rabbit Protein Kinase, CGMP-Dependent, Type I (PRKG1) interaction partners

  1. The novel cGMP/PKG/ROS (show ROS1 Proteins)/calmodulin (show CALM Proteins)/CaMKII (show CAMK2G Proteins) signaling pathway may regulate cardiomyocyte excitability by opening K(ATP) channels and contribute to cardiac protection against ischemia-reperfusion injury.

Protein Kinase, CGMP-Dependent, Type I (PRKG1) Protein Profile

Protein Summary

Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.

Gene names and symbols associated with PRKG1

  • protein kinase, cGMP-dependent, type Ia (prkg1a)
  • protein kinase, cGMP-dependent, type I (PRKG1)
  • protein kinase, cGMP-dependent, type I (prkg1)
  • protein kinase, cGMP-dependent, type 1 (Prkg1)
  • protein kinase, cGMP-dependent, type I (Prkg1)
  • 1 protein
  • AW125416 protein
  • cGK protein
  • cGK 1 protein
  • cGK1 protein
  • CGKI protein
  • cGKI-alpha protein
  • cGKI-beta protein
  • Gm19690 protein
  • PKG protein
  • Pkgi protein
  • prkg1 protein
  • Prkg1b protein
  • Prkg1beta protein
  • Prkgr1b protein
  • zgc:63955 protein

Protein level used designations for PRKG1

cGMP-dependent protein kinase 1 , protein kinase, cGMP-dependent, type I , cGMP-dependent protein kinase 1, beta isozyme , cGMP-dependent protein kinase I alpha , cGK I alpha , cGMP-dependent protein kinase 1-like , cGMP dependent protein kinase type 1 , protein kinase, cGMP-dependent, regulatory, type I, beta , CGK 1 alpha , cGK 1 beta , cGK1 , cGKI-alpha , cGMP-dependent protein kinase 1, alpha isozyme , cGMP-dependent protein kinase I , cGK 1 , PKG1 alpha , cGMP-dependent protein kinase type 1 alpha , cGMP-dependent protein kinase type I beta

GENE ID SPECIES
394005 Danio rerio
744467 Pan troglodytes
100049290 Oryzias latipes
100388016 Callithrix jacchus
54286 Rattus norvegicus
5592 Homo sapiens
282004 Bos taurus
19091 Mus musculus
100008694 Oryctolagus cuniculus
733640 Sus scrofa
423682 Gallus gallus
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