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PRKD1 is a serine/threonine kinase that regulates a variety of cellular functions, including membrane receptor signaling, transport at the Golgi, protection from oxidative stress at the mitochondria, gene transcription, and regulation of cell shape, motility, and adhesion (summary by Eiseler et al., 2009 [PubMed 19329994]).[supplied by OMIM, Nov 2010].. Additionally we are shipping Protein Kinase D1 Antibodies (160) and Protein Kinase D1 Kits (20) and many more products for this protein.
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cloning and expression analysis of a protein kinase C gene, PKCmu, and its regulation of the promoter region (PKCmu)
PKD1 (show PKD1 Proteins) contributes to the regulation of physiological angiogenesis and lymphangiogenesis during zebrafish development and is essential for tumor angiogenesis.
MC stimulation by physical contact with T cells results in PKD activation, leading to the phosphorylation of p38 (show CRK Proteins), degranulation and release of cytokines. Understanding the molecular events associated with T cell-induced MC activation might lead to therapeutic approaches for controlling T cell-mediated inflammatory processes in which MC participate.
Data suggest the role of the phospholipase C epsilon-Protein kinase D-PEA15 (show PEA15 Proteins) protein-ribosomal S6 kinase (show RPS6KB1 Proteins)-IkappaB-NF-kappa B (show NFKB1 Proteins) pathway in facilitating inflammation and inflammation-associated carcinogenesis in the colon.
PRKD1 Mutation is not associated with Solid Tumors and Leukemias.
Knockdown of PKD1 (show PKD1 Proteins) did not affect NMDAR (show GRIN1 Proteins) internalization but prevented the phosphorylation and inhibition of remaining surface NMDARs and NMDAR (show GRIN1 Proteins)-mediated synaptic functions.
Studies indicate that the loss of protein kinase D PKD1 is thought to promote invasion and metastasis, while PKD2 (show PKD2 Proteins) and upregulated PKD3 (show PRKD3 Proteins) to be positive regulators of proliferation.
it is highly possible that PKD1 (show PKD1 Proteins) plays a critical role in signal transduction from the PKC (show PRRT2 Proteins) pathway to the tyrosine kinase (show TXK Proteins) pathway
Positional mapping of PRKD1, NRP1 (show NELL1 Proteins) and PRDM1 (show PRDM1 Proteins) as novel candidate disease genes in truncus arteriosus
Protein kinase D is increased and activated in lung epithelial cells and macrophages in idiopathic pulmonary fibrosis.
a positive relationship between L1 and pPKD1 in both cultured cerebellar neurons and human cerebellar tissue, suggesting that L1 functions in the modulation of PKD1 (show PKD1 Proteins) phosphorylation.
our results demonstrate that PKD1 (show PKD1 Proteins) signaling plays a cell survival role during early stages of oxidative stress in dopaminergic neurons
Our studies demonstrate that PKD1 (show PKD1 Proteins)/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha (show DGKA Proteins) effect on MVB secretory traffic.
Our results show that AKAP13-PKD1 (show PKD1 Proteins) signaling is critical for transcriptional regulation of key contractile, cell death, and metabolic pathways during the development of compensatory hypertrophy in vivo.
PKD1 (show PKD1 Proteins) acts downstream of TGFalpha and Kras, to mediate formation of ductal structures through activation of the Notch (show NOTCH1 Proteins) pathway.
Results reveal that whereas protein kinase D1 and protein kinase D2 (show PKD2 Proteins) are essential for neuronal polarity, there exists a functional redundancy between the two proteins.
PKD controls synaptic plasticity and learning by regulating actin stability in dendritic spines.
regulatory kinase of eNOS (show NOS3 Proteins) in endothelial cells whose activity orchestrates mammalian vascular tone
Overexpression of constitutively active PKD1 (show PKD1 Proteins) in rodent heart results in dilated cardiomyopathy.
PKD1 (show PKD1 Proteins)-deficient keratinocytes showed an increase in transglutaminase expression and activity, indicating an anti-differentiative role of PKD1 (show PKD1 Proteins). Furthermore, the PKD1 (show PKD1 Proteins)-deficient keratinocytes exhibited decreased proliferation.
BTK (show BTK Proteins) and protein kinase C mu, that are involved in TLR7 (show TLR7 Proteins)/9-triggered IFN-beta (show IFNB1 Proteins) production in dendritic cells.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
Data indicate that Ser738/742-to-glutamate (show GRIN2A Proteins) protein kinase D mutant increased AngII-induced CREB (show CREB1 Proteins) protein and activating transcription factor 2 (show ATF2 Proteins) phosphorylation, and phospho-CREB (show CREB1 Proteins) binding to the steroidogenic acute regulatory protein (show STAR Proteins) promoter.
These results indicate that PKD is downstream of PLD and suggest that PKD is one of the mechanisms through which PLD promotes aldosterone production in response to AngII in adrenal glomerulosa cells.
PKD mediates acute AngII-induced aldosterone secretion.
Protein kinase D-HDAC5 pathway plays an important role in VEGF regulation of gene transcription and angiogenesis
PRKD1 is a serine/threonine kinase that regulates a variety of cellular functions, including membrane receptor signaling, transport at the Golgi, protection from oxidative stress at the mitochondria, gene transcription, and regulation of cell shape, motility, and adhesion (summary by Eiseler et al., 2009
protein kinase D1
, protein kinase C, mu
, serine/threonine-protein kinase D1-like
, protein kinase C mu type
, protein kinase D
, serine/threonine-protein kinase D1
, protein kinase C mu