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Contributes to invasiveness in malignant prostate cancer.. Additionally we are shipping Protein Kinase N3 Antibodies (54) and many more products for this protein.
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PKN3 is the major regulator of angiogenesis in humans and mice and tumor metastasis in mice.
PKN3 can be considered a novel protein implicated in remodeling the actin-adherens junction, possibly by linking ICAM-1-signaling with actin/AJ dynamics.
PKN (show PKN1 Proteins) isoforms are not simply redundant in supporting migration, but appear to be linked through isoform specific regulatory domain properties to selective upstream signals. It
PKN3 might represent a preferred target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of phosphoinositide 3-kinase
Data demonstrate that PKN3 physically interacts with Rho-family GTPases, and preferentially with RhoC (show RHOC Proteins), a known mediator of tumor invasion and metastasis in epithelial cancers.
Contributes to invasiveness in malignant prostate cancer.
protein kinase C-like 2
, protein kinase N3
, serine/threonine-protein kinase N3
, serine/threonine-protein kinase N3-like
, protein kinase PKN-beta
, protein-kinase C-related kinase 3
, protein kinase PKNbeta