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Protein O-Linked Mannose Beta1,2-N-Acetylglucosaminyltransferase Proteins (POMGNT1)

The protein encoded by POMGNT1 is a type II transmembrane protein that resides in the golgi. Additionally we are shipping Protein O-Linked Mannose Beta1,2-N-Acetylglucosaminyltransferase Antibodies (17) and Protein O-Linked Mannose Beta1,2-N-Acetylglucosaminyltransferase Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
POMGNT1 68273 Q91X88
POMGNT1 55624 Q8WZA1
Rat POMGNT1 POMGNT1 362567 Q5XIN7
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Top Protein O-Linked Mannose Beta1,2-N-Acetylglucosaminyltransferase Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_HEK293 Human His tag   50 μg Log in to see 5 Days
$522.50
Details
HOST_Human Human Un-conjugated   10 μg Log in to see 11 to 14 Days
$160.55
Details

POMGNT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
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Human , , , ,
, ,

More Proteins for Protein O-Linked Mannose Beta1,2-N-Acetylglucosaminyltransferase (POMGNT1) Interaction Partners

Mouse (Murine) Protein O-Linked Mannose Beta1,2-N-Acetylglucosaminyltransferase (POMGNT1) interaction partners

  1. Findings suggest that PomGnT1 promotes GBM progression via activation of beta-catenin (show CTNNB1 Proteins) and may serve as a prognostic factor for glioma patient survival as well as a novel molecular target for anticancer therapy in malignant glioma.

  2. POMGnT1 gene knockout cause basement membrane disruptions in a mouse model of dystroglycanopathy.

  3. Results describe the effect of altered glycosylation of alpha-dystroglycan caused by inactivation of POMGnT1 in the retina.

  4. classical beta1,2-elongation and beta1,6-GlcNAc branching of O-mannose glycan structures are dependent upon the POMGnT1 enzyme and O-mannosylation is not limited solely to alpha-DG in the brain

  5. POMGnT1 knockout mice were viable but with reduced fertility and variable lifespan

  6. The present study provides the first genetic animal model to further dissect the roles of POMGnT1 in MEB disease.

  7. From these findings, we propose that fukutin (show FKTN Proteins) forms a complex with POMGnT1 and may modulate its enzymatic activity.

  8. POMGnT1(-/-) muscle showed minimal pathological changes with very low-serum creatine kinase levels, and had normally formed muscle basal lamina, but showed reduced muscle mass, reduced numbers of muscle fibers, and impaired muscle regeneration.

Human Protein O-Linked Mannose Beta1,2-N-Acetylglucosaminyltransferase (POMGNT1) interaction partners

  1. When association tests were applied to data from the Diabetes Heart Study, it found exome variants of POMGNT1 and JAK1 (show JAK1 Proteins) genes were associated with type 2 diabetes.

  2. POMGNT1 Is Glycosylated by Mucin (show SLC13A2 Proteins)-Type O-Glycans

  3. study presents clinical, neuroradiological, and POMGNT1 findings in 12 muscle-eye-brain disease patients of Turkish origin from 10 families; suggests a genotype-phenotype correlation

  4. Data indicate that Golgi phosphoprotein 3 (GOLPH3 (show GOLPH3 Proteins)) binds to and controls the Golgi localization of protein O-linked mannose beta-1,2-N-acetlyglucosaminyltransferase 1 (POMGnT1).

  5. Identification of novel POMGnT1 mutations in Chinese patients with muscle-eye-brain disease.

  6. POMGnT1 point mutations and protein expression are associated with variably severe muscle-eye-brain disease showing that severity of the phenotype does not correlate with protein expression.

  7. Promoter alteration causes transcriptional repression of the POMGNT1 gene in limb-girdle muscular dystrophy type 2O.

  8. This study demonistreated that Intragenic rearrangements in POMGNT1 gene in muscle-eye-brain disease.

  9. these results show that the amino acid sequence affects POMGnT1 activity.

  10. This study gives a comprehensive biochemical evaluation of all clinically relevant POMGnT1 point mutations known to date, which have been linked to muscle-eye-brain disease or similar conditions.

Protein O-Linked Mannose Beta1,2-N-Acetylglucosaminyltransferase (POMGNT1) Protein Profile

Protein Summary

The protein encoded by this gene is a type II transmembrane protein that resides in the golgi. It participates in O-mannosyl glycosylation, and is specific for alpha linked terminal mannose. Mutations in this gene are associated with muscle-eye-brain (MEB) disease. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with POMGNT1

  • protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase (POMGNT1)
  • protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) (pomgnt1)
  • protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase (pomgnt1)
  • protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase (Pomgnt1)
  • protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) (POMGNT1)
  • protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) (Pomgnt1)
  • 0610016I07Rik protein
  • 4930467B06Rik protein
  • gnT-I.2 protein
  • GNTI.2 protein
  • GnT I.2 protein
  • im:7151461 protein
  • LGMD2O protein
  • MDDGA3 protein
  • MDDGB3 protein
  • MDDGC3 protein
  • MEB protein
  • MGAT1.2 protein
  • POMGNT1 protein
  • zgc:158130 protein

Protein level used designations for POMGNT1

protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase , O-linked mannose beta1,2-N-acetylglucosaminyltransferase , protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 , O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 , O-mannosyl N-acetylglucosaminyltransferase , UDP-GlcNAc:alpha-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.2

GENE ID SPECIES
429097 Gallus gallus
456564 Pan troglodytes
482511 Canis lupus familiaris
495292 Xenopus laevis
571876 Danio rerio
707205 Macaca mulatta
100158594 Xenopus (Silurana) tropicalis
100174367 Pongo abelii
100590586 Nomascus leucogenys
68273 Mus musculus
506551 Bos taurus
55624 Homo sapiens
362567 Rattus norvegicus
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