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anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) Antibodies

The protein encoded by PPM1A is a member of the PP2C family of Ser/Thr protein phosphatases. Additionally we are shipping Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Proteins (16) and Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PPM1A 19042 P49443
PPM1A 5494 P35813
PPM1A 24666 P20650
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Top anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Antibodies at antibodies-online.com

Showing 10 out of 64 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-PPM1A Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Human heart 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated EIA, IHC (p), IP, WB Immunoblot analysis Mouse liver cytosol extract was resolved by electrophoresis, transferred to PVDF membrane and probed with anti-PP2Calpha(1:250). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and a DAP detection system. Arrow indicates PP2Calpha(~43kDa) 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Human Mouse Un-conjugated FACS, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Flow cytometric analysis of HeLa cells using PPM1A mouse mAb (green) and negative control (red) . 0.1 mg Log in to see 3 to 4 Days
$430.10
Details
Mouse Rabbit Un-conjugated IP, ELISA, WB 100 μg Log in to see 16 Days
$218.90
Details
Human Rabbit Un-conjugated WB PPM1A Antibody (pS) (ABIN658234) western blot analysis in SK-BR-3 cell line lysates (35 µg/lane). This demonstrates the PPM1A antibody detected the PPM1A protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IP, ELISA, WB 100 μL Log in to see 7 to 8 Days
$374.00
Details
Human Mouse Un-conjugated FACS, ELISA, WB 100 μg Log in to see 8 to 10 Days
$551.83
Details
Human Mouse Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$566.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Mouse Rabbit Un-conjugated ELISA   100 μg Log in to see 16 Days
$163.90
Details

PPM1A Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,
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Rat (Rattus)
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Top referenced anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Antibodies

  1. Human Monoclonal PPM1A Primary Antibody for FACS, ELISA - ABIN969556 : Sun, Yu, Dotti, Shen, Tan, Savoldo, Pass, Chu, Zhang, Lu, Fu, Lin, Yang: PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation. in Cellular signalling 2008 (PubMed)
    Show all 2 references for ABIN969556

  2. Human Monoclonal PPM1A Primary Antibody for EIA, IHC (p) - ABIN121149 : Das, Helps, Cohen, Barford: Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution. in The EMBO journal 1997 (PubMed)
    Show all 2 references for ABIN121149

  3. Mouse (Murine) Polyclonal PPM1A Primary Antibody for ELISA - ABIN2000687 : Soares, Marc, Reeve: Conserved eukaryotic histone-fold residues substituted into an archaeal histone increase DNA affinity but reduce complex flexibility. in Journal of bacteriology 2003 (PubMed)

  4. Human Monoclonal PPM1A Primary Antibody for IP, ELISA - ABIN165454 : Lin, Duan, Liang, Su, Wrighton, Long, Hu, Davis, Wang, Brunicardi, Shi, Chen, Meng, Feng: PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling. in Cell 2006 (PubMed)

  5. Chicken Polyclonal PPM1A Primary Antibody for WB - ABIN2787379 : Wu, Wang, Yang, Feng, Zhao, Yang: Expression of PTEN, PPM1A and P-Smad2 in hepatocellular carcinomas and adjacent liver tissues. in World journal of gastroenterology : WJG 2007 (PubMed)

More Antibodies against Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Interaction Partners

Mouse (Murine) Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) interaction partners

  1. findings demonstrate a novel regulatory circuit in which STING and TBK1 (show TBK1 Antibodies) reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A dephosphorylates STING and TBK1 (show TBK1 Antibodies)

  2. the studies presented here position PPM1A as a new player in the wound healing-inflammation-angiogenesis axis in mouse, reveal its crucial role in homeostasis on injury, and highlight its potential as a therapeutic mediator in pathologic conditions

  3. a nuclear envelope-localized mechanism of inactivating TGF-beta (show TGFB1 Antibodies) signaling in which MAN1 (show LEMD3 Antibodies) competes with transcription factors for binding to Smad2 (show SMAD2 Antibodies) and Smad3 (show SMAD3 Antibodies) and facilitates their dephosphorylation by PPM1A.

  4. Although a non-myristoylated mutation (G2A (show GPR132 Antibodies)) of PPM1A and PPM1B (show PPM1B Antibodies) prevented membrane association, this relocalization did not likely cause the decreased activity towards AMPKalpha (show GRK4 Antibodies).

  5. we found that PPM1A mRNA is synthesized at the beginning of the maturation process and remains elevated in the mature oocytes, promoting the accumulation of PPM1A protein

  6. Protein phosphatase PPM1A regulates the nuclear export of Smad2 (show SMAD2 Antibodies)/3 through targeting nuclear exporter RanBP3 (show RANBP3 Antibodies).

  7. Ppm1a, through suppressing Smad2 (show SMAD2 Antibodies) signaling, plays a critical role in re-epithelialization during wound healing

  8. Molecular cloning and expression analysis of MPP alpha-2, a novel transcript detected in a differential screen of pituitary libraries (MPPalpha 2)

  9. Protein phosphatase 1alpha is required for lung growth and morphogenesis.

Human Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) interaction partners

  1. findings demonstrate a novel regulatory circuit in which STING and TBK1 (show TBK1 Antibodies) reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A dephosphorylates STING and TBK1 (show TBK1 Antibodies)

  2. The TGF-beta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) signaling system decreases its activity through strong negative regulation. We provide evidence for a new negative feedback loop through PPM1A upregulation.

  3. Loss of PPM1A is associated with the development of tumor invasion in bladder cancer patients.

  4. PPM1A is a RelA (show NFkBP65 Antibodies) phosphatase that regulates NF-kappaB (show NFKB1 Antibodies) activity and that PPM1A has tumor suppressor-like activity.

  5. a nuclear envelope-localized mechanism of inactivating TGF-beta (show TGFB1 Antibodies) signaling in which MAN1 (show LEMD3 Antibodies) competes with transcription factors for binding to Smad2 (show SMAD2 Antibodies) and Smad3 (show SMAD3 Antibodies) and facilitates their dephosphorylation by PPM1A.

  6. phosphatase activity toward phosphopeptide substrates by PP2Calpha and Wip1 (show PPM1D Antibodies) requires the binding of a Mg(2 (show MUC7 Antibodies))+ ion to the low-affinity site.

  7. PPM1A negatively regulates ERK (show EPHB2 Antibodies) by directly dephosphorylating its pThr202 position early in epidermal growth factor (show EGF Antibodies) stimulation. Additional kinetic studies reveal that key residues participate in phospho-ERK (show EPHB2 Antibodies) recognition by PPM1A.

  8. Studies indicate that phosphatase PPM1G (show PPM1G Antibodies) is a component of the spliceosome and binds to protein YB-1 (show YBX1 Antibodies) to affect alternative splicing.

  9. PPM1A inhibits HIV-1 infection and gene expression. PPM1A depletion in resting CD4 (show CD4 Antibodies)+ T cells increases HIV-1 gene expression.

  10. High expression of LMP2 (show PSMB9 Antibodies) and low expression of PPM1A might play an important role in the motility and invasiveness of trophoblast cells and malignant transformation of hydatidiform mole.

Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Gene names and symbols associated with PPM1A

  • protein phosphatase 1A-like (LOC100738389) antibody
  • protein phosphatase 1A, magnesium dependent, alpha isoform (Ppm1a) antibody
  • protein phosphatase, Mg2+/Mn2+ dependent, 1A (PPM1A) antibody
  • protein phosphatase, Mg2+/Mn2+ dependent, 1A (Ppm1a) antibody
  • protein phosphatase, Mg2+/Mn2+ dependent, 1A (ppm1a) antibody
  • protein phosphatase, Mg2+/Mn2+ dependent, 1Aa (ppm1aa) antibody
  • protein phosphatase, Mg2+/Mn2+ dependent, 1Bb (ppm1bb) antibody
  • 2310003C21Rik antibody
  • 2900017D14Rik antibody
  • AI427932 antibody
  • AU017636 antibody
  • fc18g04 antibody
  • MMPa-2 antibody
  • MPPa-1 antibody
  • pp2c-alpha antibody
  • Pp2c1 antibody
  • pp2ca antibody
  • pp2ca2 antibody
  • pp2calpha antibody
  • ppm1a antibody
  • wu:fc18g04 antibody
  • zgc:92329 antibody

Protein level used designations for PPM1A

Mpp alpha , PP2C-alpha , protein phosphatase 1A , protein phosphatase 2C isoform alpha , protein phosphatase IA , protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform , IA , Protein phosphatase type 1A (formely 2C) Mg-dependent alpha isoform , Protein phosphatase type 1A (formely 2C), Mg-dependent, alpha isoform , protein phosphatase 1A, magnesium dependent, alpha isoform , protein phosphatase 2C alpha , protein phosphatase type 2C alpha 2 , protein phosphatase 1A, magnesium dependent, alpha

GENE ID SPECIES
100738389 Sus scrofa
19042 Mus musculus
5494 Homo sapiens
24666 Rattus norvegicus
380058 Xenopus laevis
423525 Gallus gallus
480344 Canis lupus familiaris
281994 Bos taurus
100009431 Oryctolagus cuniculus
100734826 Cavia porcellus
30704 Danio rerio
100003481 Danio rerio
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