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Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Proteins (PPM1A)

The protein encoded by PPM1A is a member of the PP2C family of Ser/Thr protein phosphatases. Additionally we are shipping Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Antibodies (84) and Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PPM1A 19042 P49443
PPM1A 5494 P35813
PPM1A 24666 P20650
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Top Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Proteins at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 2 to 3 Days
$309.75
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,048.83
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$3,048.83
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Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,048.83
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$273.57
Details

PPM1A Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
,
Rat (Rattus)

Top referenced Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Proteins

  1. Human PPM1A Protein expressed in Escherichia coli (E. coli) - ABIN2005363 : Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ... in Genome research 2004 (PubMed)

More Proteins for Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) Interaction Partners

Mouse (Murine) Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) interaction partners

  1. findings demonstrate a novel regulatory circuit in which STING and TBK1 (show TBK1 Proteins) reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A dephosphorylates STING and TBK1 (show TBK1 Proteins)

  2. the studies presented here position PPM1A as a new player in the wound healing-inflammation-angiogenesis axis in mouse, reveal its crucial role in homeostasis on injury, and highlight its potential as a therapeutic mediator in pathologic conditions

  3. a nuclear envelope-localized mechanism of inactivating TGF-beta (show TGFB1 Proteins) signaling in which MAN1 (show LEMD3 Proteins) competes with transcription factors for binding to Smad2 (show SMAD2 Proteins) and Smad3 (show SMAD3 Proteins) and facilitates their dephosphorylation by PPM1A.

  4. Although a non-myristoylated mutation (G2A (show GPR132 Proteins)) of PPM1A and PPM1B (show PPM1B Proteins) prevented membrane association, this relocalization did not likely cause the decreased activity towards AMPKalpha (show GRK4 Proteins).

  5. we found that PPM1A mRNA is synthesized at the beginning of the maturation process and remains elevated in the mature oocytes, promoting the accumulation of PPM1A protein

  6. Protein phosphatase PPM1A regulates the nuclear export of Smad2 (show SMAD2 Proteins)/3 through targeting nuclear exporter RanBP3 (show RANBP3 Proteins).

  7. Ppm1a, through suppressing Smad2 (show SMAD2 Proteins) signaling, plays a critical role in re-epithelialization during wound healing

  8. Molecular cloning and expression analysis of MPP alpha-2, a novel transcript detected in a differential screen of pituitary libraries (MPPalpha 2)

  9. Protein phosphatase 1alpha is required for lung growth and morphogenesis.

Human Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) interaction partners

  1. findings demonstrate a novel regulatory circuit in which STING and TBK1 (show TBK1 Proteins) reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A dephosphorylates STING and TBK1 (show TBK1 Proteins)

  2. The TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signaling system decreases its activity through strong negative regulation. We provide evidence for a new negative feedback loop through PPM1A upregulation.

  3. Loss of PPM1A is associated with the development of tumor invasion in bladder cancer patients.

  4. PPM1A is a RelA (show NFkBP65 Proteins) phosphatase that regulates NF-kappaB (show NFKB1 Proteins) activity and that PPM1A has tumor suppressor-like activity.

  5. a nuclear envelope-localized mechanism of inactivating TGF-beta (show TGFB1 Proteins) signaling in which MAN1 (show LEMD3 Proteins) competes with transcription factors for binding to Smad2 (show SMAD2 Proteins) and Smad3 (show SMAD3 Proteins) and facilitates their dephosphorylation by PPM1A.

  6. phosphatase activity toward phosphopeptide substrates by PP2Calpha and Wip1 (show PPM1D Proteins) requires the binding of a Mg(2 (show MUC7 Proteins))+ ion to the low-affinity site.

  7. PPM1A negatively regulates ERK (show EPHB2 Proteins) by directly dephosphorylating its pThr202 position early in epidermal growth factor (show EGF Proteins) stimulation. Additional kinetic studies reveal that key residues participate in phospho-ERK (show EPHB2 Proteins) recognition by PPM1A.

  8. Studies indicate that phosphatase PPM1G (show PPM1G Proteins) is a component of the spliceosome and binds to protein YB-1 (show YBX1 Proteins) to affect alternative splicing.

  9. PPM1A inhibits HIV-1 infection and gene expression. PPM1A depletion in resting CD4 (show CD4 Proteins)+ T cells increases HIV-1 gene expression.

  10. High expression of LMP2 (show PSMB9 Proteins) and low expression of PPM1A might play an important role in the motility and invasiveness of trophoblast cells and malignant transformation of hydatidiform mole.

Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Gene names and symbols associated with PPM1A

  • protein phosphatase 1A-like (LOC100738389)
  • protein phosphatase 1A, magnesium dependent, alpha isoform (Ppm1a)
  • protein phosphatase, Mg2+/Mn2+ dependent, 1A (PPM1A)
  • protein phosphatase, Mg2+/Mn2+ dependent, 1A (Ppm1a)
  • protein phosphatase, Mg2+/Mn2+ dependent, 1A (ppm1a)
  • protein phosphatase, Mg2+/Mn2+ dependent, 1Aa (ppm1aa)
  • protein phosphatase, Mg2+/Mn2+ dependent, 1Bb (ppm1bb)
  • 2310003C21Rik protein
  • 2900017D14Rik protein
  • AI427932 protein
  • AU017636 protein
  • fc18g04 protein
  • MMPa-2 protein
  • MPPa-1 protein
  • pp2c-alpha protein
  • Pp2c1 protein
  • pp2ca protein
  • pp2ca2 protein
  • pp2calpha protein
  • ppm1a protein
  • wu:fc18g04 protein
  • zgc:92329 protein

Protein level used designations for PPM1A

Mpp alpha , PP2C-alpha , protein phosphatase 1A , protein phosphatase 2C isoform alpha , protein phosphatase IA , protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform , IA , Protein phosphatase type 1A (formely 2C) Mg-dependent alpha isoform , Protein phosphatase type 1A (formely 2C), Mg-dependent, alpha isoform , protein phosphatase 1A, magnesium dependent, alpha isoform , protein phosphatase 2C alpha , protein phosphatase type 2C alpha 2 , protein phosphatase 1A, magnesium dependent, alpha

GENE ID SPECIES
100738389 Sus scrofa
19042 Mus musculus
5494 Homo sapiens
24666 Rattus norvegicus
380058 Xenopus laevis
423525 Gallus gallus
480344 Canis lupus familiaris
281994 Bos taurus
100009431 Oryctolagus cuniculus
100734826 Cavia porcellus
30704 Danio rerio
100003481 Danio rerio
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