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Protein Phosphatase, Mg2+/Mn2+ Dependent, 1B Proteins (PPM1B)

The protein encoded by PPM1B is a member of the PP2C family of Ser/Thr protein phosphatases. Additionally we are shipping Protein Phosphatase, Mg2+/Mn2+ Dependent, 1B Antibodies (91) and Protein Phosphatase, Mg2+/Mn2+ Dependent, 1B Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PPM1B 19043 P36993
PPM1B 5495 O75688
PPM1B 24667 P35815
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Top Protein Phosphatase, Mg2+/Mn2+ Dependent, 1B Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,072.67
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,366.00
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PPM1B Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,
Rat (Rattus)

More Proteins for Protein Phosphatase, Mg2+/Mn2+ Dependent, 1B (PPM1B) Interaction Partners

Mouse (Murine) Protein Phosphatase, Mg2+/Mn2+ Dependent, 1B (PPM1B) interaction partners

  1. Ppm1b negatively regulates necroptosis through dephosphorylating Rip3 in vitro and in vivo.

  2. the phosphatase PPM1B as a novel selective modulator of PPARgamma (show PPARG Proteins) activity.

  3. Although a non-myristoylated mutation (G2A (show GPR132 Proteins)) of PPM1A (show PPM1A Proteins) and PPM1B prevented membrane association, this relocalization did not likely cause the decreased activity towards AMPKalpha (show GRK4 Proteins).

  4. These observations suggest that relatively high PP2Cbeta expression is specifically required during the early stages of pre-implantation development.

Human Protein Phosphatase, Mg2+/Mn2+ Dependent, 1B (PPM1B) interaction partners

  1. PPM1B interacts with Groucho 4 and is localized to DNA in a Groucho-dependent manner, and phosphatase activity is required for transcriptional silencing.

  2. Results identify PPM1B as a critical regulator of both p38 MAPK (show MAPK14 Proteins)-dependent and independent senescence pathways during normal cellular aging process.

  3. Cadmium reversed PPM1A (show PPM1A Proteins)-induced cell cycle arrest and cadmium insensitive PPM1A (show PPM1A Proteins) mutant rescued cadmium induced cell death.

  4. Protein kinase A activates NF-kappaB (show NFKB1 Proteins)-mediated transcription by destabilization of PP2Cbeta.

  5. the phosphatase PPM1B as a novel selective modulator of PPARgamma (show PPARG Proteins) activity.

  6. PPM1B functions as a TBK1 (show TBK1 Proteins) phosphatase dephosphorylates TBK1 (show TBK1 Proteins) at serine 172 and terminates TBK1 (show TBK1 Proteins)-mediated IRF3 (show IRF3 Proteins) activation and IFNbeta gene expression.

  7. Studies show that Ppm1b plays a multilayered role in regulating the availability and optimal activity of the EKLF (show KLF1 Proteins) protein in erythroid cells.

  8. results implicate a novel and important role for PP2Cbetal in regulating hPXR activity and CYP3A4 (show CYP3A4 Proteins) expression by inhibiting or desensitizing signaling pathways that negatively regulate the function of pregnane X receptor (show NR1I2 Proteins) in liver cells

  9. PP2Cbeta down-regulates cytokine-induced NF-kappaB (show NFKB1 Proteins) activation by altering IKK (show CHUK Proteins) activity.

  10. Overexpression of PPM1A (show PPM1A Proteins) and the related PPM1B greatly reduced Cdk9 (show CDK9 Proteins) T-loop phosphorylation

Protein Phosphatase, Mg2+/Mn2+ Dependent, 1B (PPM1B) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences.

Gene names and symbols associated with PPM1B

  • protein phosphatase 1B, magnesium dependent, beta isoform (Ppm1b)
  • protein phosphatase, Mg2+/Mn2+ dependent, 1B (PPM1B)
  • protein phosphatase, Mg2+/Mn2+ dependent, 1B (Ppm1b)
  • protein phosphatase, Mg2+/Mn2+ dependent, 1B (ppm1b)
  • protein phosphatase, Mg2+/Mn2+ dependent, 1G (PPM1G)
  • pp2c-beta-x protein
  • Pp2c2 protein
  • pp2cb protein
  • pp2cbeta protein
  • ppc2betax protein

Protein level used designations for PPM1B

PP2C-beta , protein phosphatase 1B , protein phosphatase 2C isoform beta , protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform , protein phosphatase 2C-like protein , Protein phosphatase type 1B (formely 2C) Mg-dependent beta isoform , Protein phosphatase type 1B (formely 2C), Mg-dependent, beta isoform , protein phosphatase 1B, magnesium dependent, beta isoform , MCPP , PP2C-gamma , magnesium-dependent calcium inhibitable phosphatase , protein phosphatase 1G , protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform , protein phosphatase 2C isoform gamma , protein phosphatase magnesium-dependent 1 gamma

GENE ID SPECIES
19043 Mus musculus
5495 Homo sapiens
24667 Rattus norvegicus
443768 Xenopus laevis
421404 Gallus gallus
474573 Canis lupus familiaris
281995 Bos taurus
100356616 Oryctolagus cuniculus
286880 Bos taurus
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