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Protein Phosphatase 1, Catalytic Subunit, alpha Isoform Proteins (PPP1CA)

The protein encoded by PPP1CA is a member of the PP2C family of Ser/Thr protein phosphatases. Additionally we are shipping Protein Phosphatase 1, Catalytic Subunit, alpha Isoform Antibodies (119) and Protein Phosphatase 1, Catalytic Subunit, alpha Isoform Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PPP1CA 19045 P62137
PPP1CA 5499 P62136
PPP1CA 24668 P62138
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Top Protein Phosphatase 1, Catalytic Subunit, alpha Isoform Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 10 μg Log in to see 2 to 3 Days
$336.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 10 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,887.50
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,887.50
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,887.50
Details
Yeast Dog His tag   1 mg Log in to see 56 to 66 Days
$2,887.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 3 to 4 Days
$382.86
Details

PPP1CA Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,
Rat (Rattus)

Top referenced Protein Phosphatase 1, Catalytic Subunit, alpha Isoform Proteins

  1. Human PPP1CA Protein expressed in Escherichia coli (E. coli) - ABIN667526 : He, Gross, Roizman et al.: The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the ... in Proceedings of the National Academy of Sciences of the United States of America 1997 (PubMed)
    Show all 2 references for ABIN667526

More Proteins for Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA) Interaction Partners

Mouse (Murine) Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA) interaction partners

  1. findings demonstrate a novel regulatory circuit in which STING and TBK1 (show TBK1 Proteins) reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A (show PPM1A Proteins) dephosphorylates STING and TBK1 (show TBK1 Proteins)

  2. the studies presented here position PPM1A (show PPM1A Proteins) as a new player in the wound healing-inflammation-angiogenesis axis in mouse, reveal its crucial role in homeostasis on injury, and highlight its potential as a therapeutic mediator in pathologic conditions

  3. Ang (show ANG Proteins) IV functions via regulating the activity of PP1 (show PPP1CC Proteins)

  4. a nuclear envelope-localized mechanism of inactivating TGF-beta (show TGFB1 Proteins) signaling in which MAN1 (show LEMD3 Proteins) competes with transcription factors for binding to Smad2 (show SMAD2 Proteins) and Smad3 (show SMAD3 Proteins) and facilitates their dephosphorylation by PPM1A (show PPM1A Proteins).

  5. Although a non-myristoylated mutation (G2A (show GPR132 Proteins)) of PPM1A (show PPM1A Proteins) and PPM1B (show PPM1B Proteins) prevented membrane association, this relocalization did not likely cause the decreased activity towards AMPKalpha (show GRK4 Proteins).

  6. we found that PPM1A (show PPM1A Proteins) mRNA is synthesized at the beginning of the maturation process and remains elevated in the mature oocytes, promoting the accumulation of PPM1A (show PPM1A Proteins) protein

  7. Cell surface expression of the major amyloid-beta peptide (Abeta (show APP Proteins))-degrading enzyme, neprilysin (show MME Proteins), depends on phosphorylation by mitogen-activated protein kinase (show MAPK1 Proteins)/extracellular signal-regulated kinase kinase (MEK (show MDK Proteins)) and dephosphorylation by protein phosphatase 1a (show PPM1A Proteins).

  8. analysis of selective regulation of NR2B (show GRIN2B Proteins) by protein phosphatase-1 (show PPP1CB Proteins) for the control of the NMDA receptor in neuroprotection

  9. Protein phosphatase PPM1A (show PPM1A Proteins) regulates the nuclear export of Smad2 (show SMAD2 Proteins)/3 through targeting nuclear exporter RanBP3 (show RANBP3 Proteins).

  10. Ppm1a (show PPM1A Proteins), through suppressing Smad2 (show SMAD2 Proteins) signaling, plays a critical role in re-epithelialization during wound healing

Human Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA) interaction partners

  1. Both PP-1 (show PPA1 Proteins) and PP-2A are directly involved in regulating eye development, and are aberrantly expressed in cataract and glaucoma patients. (Review)

  2. Data suggest that activation of TAZ (tafazzin (show TAZ Proteins)) inhibits adipogenesis in mesenchymal stem cells; interaction of TAZ (show TAZ Proteins) and protein phosphatases (PP1A, PP2A (show PPP2R4 Proteins)) up-regulates dephosphorylation and transport of TAZ (show TAZ Proteins) to cell nucleus.

  3. ATG16L1 (show ATG16L1 Proteins) as a bona fide physiological CSNK2 and PPP1 substrate, which reveals a novel molecular link from CSNK2 to activation of the autophagy-specific ATG12 (show ATG12 Proteins)-ATG5 (show ATG5 Proteins)-ATG16L1 (show ATG16L1 Proteins) complex and autophagy induction

  4. PARD3 (show PARD3 Proteins) promotes interaction between PP1A and LATS1 to induce LATS1 dephosphorylation and inactivation,leading to dephosphorylation and activation of TAZ (show TAZ Proteins)

  5. activation of the Nherf1 (show SLC9A3R1 Proteins)-PP1alpha-TAZ (show TAZ Proteins) pathway in osteoblasts is targeted by histone deacetylase (show HDAC1 Proteins) inhibitors

  6. findings demonstrate a novel regulatory circuit in which STING and TBK1 (show TBK1 Proteins) reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A (show PPM1A Proteins) dephosphorylates STING and TBK1 (show TBK1 Proteins)

  7. Protein phosphatase 1 (show PPP1CB Proteins) (PP1 (show PPA1 Proteins)) activity is critical for radiosensitization in non-small cell lung cancer cells and PP1 (show PPA1 Proteins) activators can serve as promising radiosensitizers to improve therapeutic efficacy.

  8. The TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signaling system decreases its activity through strong negative regulation. We provide evidence for a new negative feedback loop through PPM1A (show PPM1A Proteins) upregulation.

  9. Loss of PPM1A (show PPM1A Proteins) is associated with the development of tumor invasion in bladder cancer patients.

  10. PP1alpha is an important proximal effector of Manumycin-A mediated lymphoma cell apoptosis.

Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Gene names and symbols associated with PPP1CA

  • protein phosphatase 1, catalytic subunit, alpha isozyme (ppp1ca)
  • protein phosphatase 1, catalytic subunit, alpha isozyme (PPP1CA)
  • protein phosphatase 1, catalytic subunit, alpha isoform (Ppp1ca)
  • protein phosphatase 1, catalytic subunit, alpha isoform a (ppp1caa)
  • protein phosphatase 1, catalytic subunit, alpha isozyme (Ppp1ca)
  • protein phosphatase 1, catalytic subunit, beta isozyme (Ppp1cb)
  • protein phosphatase 1A, magnesium dependent, alpha isoform (Ppm1a)
  • protein phosphatase, Mg2+/Mn2+ dependent, 1A (PPM1A)
  • 2310003C21Rik protein
  • 2900017D14Rik protein
  • AI427932 protein
  • AU017636 protein
  • dism2 protein
  • MMPa-2 protein
  • MPPa-1 protein
  • PP-1A protein
  • PP1A protein
  • PP1alpha protein
  • PP2C-ALPHA protein
  • PP2CA protein
  • PP2Calpha protein
  • PPP1A protein
  • Ppp1c protein
  • wu:fc04c08 protein
  • wu:fc09b07 protein
  • wu:fc30g11 protein
  • wu:fe05h08 protein
  • zgc:85729 protein

Protein level used designations for PPP1CA

Protein phosphatase type 1 alpha, catalytic subunit , protein phosphatase 1, catalytic subunit, alpha isoform , PP-1A , serine/threonine-protein phosphatase PP1-alpha catalytic subunit , ppp1ca , protein phosphatase 1, catalytic subunit, alpha , serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit , protein phosphatase-1d , PP-1B , protein phosphatase 1, catalytic subunit, beta isoform , protein phosphatase-1a , serine/threonine-protein phosphatase PP1-beta catalytic subunit , Mpp alpha , PP2C-alpha , protein phosphatase 1A , protein phosphatase 2C isoform alpha , protein phosphatase IA , protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform , IA , protein phosphatase 2C alpha

GENE ID SPECIES
379914 Xenopus laevis
745709 Pan troglodytes
100059233 Equus caballus
100145598 Xenopus (Silurana) tropicalis
19045 Mus musculus
407980 Danio rerio
5499 Homo sapiens
24668 Rattus norvegicus
516175 Bos taurus
403609 Canis lupus familiaris
100009298 Oryctolagus cuniculus
25594 Rattus norvegicus
19042 Mus musculus
5494 Homo sapiens
281994 Bos taurus
100009431 Oryctolagus cuniculus
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