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anti-Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A (PPP1R15A) Antibodies

PPP1R15A is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. Additionally we are shipping Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A Proteins (7) and Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PPP1R15A 17872 P17564
PPP1R15A 23645 O75807
PPP1R15A 171071 Q6IN02
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Top anti-Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A Antibodies at antibodies-online.com

Showing 10 out of 61 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated IHC (p), WB 20 μg Log in to see 6 to 8 Days
$203.50
Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN184571 (0.1 µg/mL) staining of HEPG2 cell lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Mouse Un-conjugated FACS, IF, IHC, WB HEK293T cells transfected with either RC200581 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-PPP1R15A antibody (ABIN2455567), and then analyzed by flow cytometry. Anti-PPP1R15A mouse monoclonal antibody (ABIN2455567) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PPP1R15A (RC200581). 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, IHC, WB HEK293T cells transfected with either RC200581 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-PPP1R15A antibody (ABIN2455603), and then analyzed by flow cytometry. HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PPP1R15A (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-PPP1R15A. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, IF, IHC, WB HEK293T cells transfected with either RC200581 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-PPP1R15A antibody (ABIN2455569), and then analyzed by flow cytometry. Anti-PPP1R15A mouse monoclonal antibody (ABIN2455569) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PPP1R15A (RC200581). 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, IF, WB Anti-PPP1R15A mouse monoclonal antibody (ABIN2455566) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PPP1R15A (RC200581). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PPP1R15A (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-PPP1R15A. 100 μL Log in to see 2 to 3 Days
$482.90
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated FACS, IF, IHC (p), WB 100 μL Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated FACS, IHC (p), WB 100 μL Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Un-conjugated IF (p), IHC (p) Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-GADD34 Polyclonal Antibody, Unconjugated (ABIN2174278) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 14 to 21 Days
$269.50
Details

PPP1R15A Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A Antibodies

  1. Human Polyclonal PPP1R15A Primary Antibody for IHC (p), WB - ABIN782866 : Panaretakis, Kepp, Brockmeier, Tesniere, Bjorklund, Chapman, Durchschlag, Joza, Pierron, van Endert, Yuan, Zitvogel, Madeo, Williams, Kroemer: Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. in The EMBO journal 2009 (PubMed)

  2. Human Polyclonal PPP1R15A Primary Antibody for IHC, ELISA - ABIN184571 : Kojima, Takeuchi, Haneda, Yagi, Hasegawa, Yamaki, Takeda, Akira, Shimokata, Isobe: The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient mice. in The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003 (PubMed)

More Antibodies against Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A Interaction Partners

Mouse (Murine) Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A (PPP1R15A) interaction partners

  1. Through aging or a high fat diet, insulin (show INS Antibodies) signaling in GADD34-deficient liver converted to be down regulated compared with WT mice.

  2. Results show that GADD34 plays a vital role in promoting cell death following proteasome inhibition via enhancing protein synthesis involved in endoplasmic reticulum stress, reactive oxygen species production and autophagy formation.

  3. avidity for the substrate plays an important role in imparting specificity on the PPP1R15B-PP1G-actin ternary complex.

  4. GADD34 enhances autophagy and suppresses apoptosis stimulated by LPS (show TLR4 Antibodies) combined with amino acid deprivation through regulation of mTOR (show FRAP1 Antibodies) signaling pathway in macrophages.

  5. GADD34 upregulated pro-inflammatory mediator.

  6. GADD34 promotes cell survival and adaptation to increased extracellular osmolarity by increasing the uptake of small neutral amino acids via the amino acid transporter SNAT2 (show SLC38A2 Antibodies).

  7. GADD34 expression was upregulated in the liver of mice after exposure to a carcinogen, diethylnitrosamine (DEN). In both acute and chronic DEN treatment models, GADD34 deficiency not only decreased oncogene (show RAB1A Antibodies) expression, but also reduced hepatic damage.

  8. Thus these results indicate that GADD34 appears to suppress myofibroblast differentiation through inhibiting Smad3 (show SMAD3 Antibodies)-dependent TGFbeta (show TGFB1 Antibodies) signal pathway and promote its apoptosis by activating caspase-3 (show CASP3 Antibodies) pathway

  9. GADD34 works to inhibit the proliferation and differentiation of HSCs or myeloid precursor cells and maintains homeostatic differentiation of neutrophil-lineage cells to avoid early immunological senescence.

  10. Data indicate that GADD34 is the regulatory subunit of rotein phosphatase-1 (PP1 (show PPP1CC Antibodies)) to specify PP1 (show PPP1CC Antibodies) to dephosphorylate TGF-beta-activated kinase 1 (TAK1 (show MAP3K7 Antibodies)) Ser412.

Human Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A (PPP1R15A) interaction partners

  1. The reactive oxygen species-generating NADPH oxidase-4 (Nox4 (show NOX4 Antibodies)) is induced downstream of ATF4 (show ATF4 Antibodies), binds to a PP1 (show PPA1 Antibodies)-targeting subunit GADD34 at the endoplasmic reticulum, and inhibits PP1 (show PPA1 Antibodies) activity to increase eIF2alpha (show EIF2A Antibodies) phosphorylation and ATF4 (show ATF4 Antibodies) levels.

  2. stress pathways lead to the induction of the protein GADD34, which appears to provide protection against the toxic effects of the secreted virulence factors in Pseudomonas aeruginosa infection

  3. The data highlight independent interactions of PP1 (show PPA1 Antibodies) and eIF2alpha (show EIF2A Antibodies) with GADD34, demonstrating that GADD34 functions as a scaffold both in vitro and in cells

  4. GADD34 may play a neuroprotective role against amyloid-beta toxicity.

  5. GADD34 enhances autophagy and suppresses apoptosis stimulated by LPS (show IRF6 Antibodies) combined with amino acid deprivation through regulation of mTOR (show FRAP1 Antibodies) signaling pathway in macrophages.

  6. Data indicate that protein phosphatase 1 (show PPP1CB Antibodies) subunit GADD34 directly interacts with eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha (show EIF2S1 Antibodies)).

  7. GADD34 was increased in neurons of human Alzheimer's disease (AD) brains. Additionally, this finding was also observed in oligodendrocytes in human AD brains. GADD34 could be a therapeutic target for preventing ER stress in neuronal cells in AD.

  8. GADD34 promotes cell survival and adaptation to increased extracellular osmolarity by increasing the uptake of small neutral amino acids via the amino acid transporter (show SLC43A2 Antibodies) SNAT2 (show SLC38A2 Antibodies).

  9. Nuclear export of HTLV-1 basic leucine-zipper factor (HBZ (show HBZ Antibodies)) is essential for its interaction with GADD34 and increased phosphorylation of S6 kinase (show RPS6KB1 Antibodies), which is an established downstream target of the mTOR (show FRAP1 Antibodies) pathway.

  10. GADD34 phosphorylation on tyrosine 262 modulates endoplasmic reticulum stress signaling and cell fate.

Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A (PPP1R15A) Antigen Profile

Protein Summary

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation.

Gene names and symbols associated with PPP1R15A

  • protein phosphatase 1, regulatory subunit 15A (PPP1R15A) antibody
  • protein phosphatase 1, regulatory (inhibitor) subunit 15A (PPP1R15A) antibody
  • protein phosphatase 1, regulatory (inhibitor) subunit 15A (Ppp1r15a) antibody
  • protein phosphatase 1, regulatory subunit 15A (Ppp1r15a) antibody
  • 9630030H21 antibody
  • GADD34 antibody
  • Myd116 antibody
  • Peg-3 antibody
  • RGD1624209 antibody

Protein level used designations for PPP1R15A

protein phosphatase 1, regulatory (inhibitor) subunit 15A , growth arrest and DNA damage-inducible protein GADD34 , growth arrest and DNA-damage-inducible 34 , myeloid differentiation primary response gene 116 , myeloid differentiation primary response protein MyD116 , protein phosphatase 1 regulatory subunit 15A , myeloid differentiation primary response protein MyD116 homolog , progression elevated gene 3 protein

GENE ID SPECIES
456191 Pan troglodytes
718350 Macaca mulatta
100449481 Pongo abelii
100591446 Nomascus leucogenys
17872 Mus musculus
23645 Homo sapiens
171071 Rattus norvegicus
514688 Bos taurus
476419 Canis lupus familiaris
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