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Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A Proteins (PPP1R15A)

PPP1R15A is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. Additionally we are shipping Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A Antibodies (68) and Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PPP1R15A 17872 P17564
PPP1R15A 23645 O75807
Rat PPP1R15A PPP1R15A 171071 Q6IN02
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Top Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Cow Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
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HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PPP1R15A Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A (PPP1R15A) Interaction Partners

Mouse (Murine) Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A (PPP1R15A) interaction partners

  1. Sustained protein synthesis sensitized cells to pharmacological induction of the Unfolded Protein Response (UPR), and the observed decrease in cell viability was restored upon inhibition of GADD34 activity. We conclude that NMP4 (show ZNF384 Proteins) is a key regulator of ribosome biogenesis and the UPR, which together play a central role in determining cell viability during endoplasmic reticulum stress.

  2. Through aging or a high fat diet, insulin (show INS Proteins) signaling in GADD34-deficient liver converted to be down regulated compared with WT mice.

  3. Results show that GADD34 plays a vital role in promoting cell death following proteasome inhibition via enhancing protein synthesis involved in endoplasmic reticulum stress, reactive oxygen species production and autophagy formation.

  4. avidity for the substrate plays an important role in imparting specificity on the PPP1R15B-PP1G-actin ternary complex.

  5. GADD34 enhances autophagy and suppresses apoptosis stimulated by LPS (show TLR4 Proteins) combined with amino acid deprivation through regulation of mTOR (show FRAP1 Proteins) signaling pathway in macrophages.

  6. GADD34 upregulated pro-inflammatory mediator.

  7. GADD34 promotes cell survival and adaptation to increased extracellular osmolarity by increasing the uptake of small neutral amino acids via the amino acid transporter SNAT2 (show SLC38A2 Proteins).

  8. GADD34 expression was upregulated in the liver of mice after exposure to a carcinogen, diethylnitrosamine (DEN). In both acute and chronic DEN treatment models, GADD34 deficiency not only decreased oncogene (show RAB1A Proteins) expression, but also reduced hepatic damage.

  9. Thus these results indicate that GADD34 appears to suppress myofibroblast differentiation through inhibiting Smad3 (show SMAD3 Proteins)-dependent TGFbeta (show TGFB1 Proteins) signal pathway and promote its apoptosis by activating caspase-3 (show CASP3 Proteins) pathway

  10. GADD34 works to inhibit the proliferation and differentiation of HSCs or myeloid precursor cells and maintains homeostatic differentiation of neutrophil-lineage cells to avoid early immunological senescence.

Human Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A (PPP1R15A) interaction partners

  1. Data of this study strengthen the evidence of an unfolded protein response during the course of RA and provide an insight of the potential interest in GADD34 as a relevant marker for RA.

  2. The results suggest that dephosphorylation of eIF2a (show EIF2S1 Proteins) by GADD34 plays an important role in doxorubicin resistance of MCF-7/ADR (show AKR1B1 Proteins) cells.

  3. The reactive oxygen species-generating NADPH oxidase-4 (Nox4 (show NOX4 Proteins)) is induced downstream of ATF4 (show ATF4 Proteins), binds to a PP1 (show PPA1 Proteins)-targeting subunit GADD34 at the endoplasmic reticulum, and inhibits PP1 (show PPA1 Proteins) activity to increase eIF2alpha (show EIF2A Proteins) phosphorylation and ATF4 (show ATF4 Proteins) levels.

  4. stress pathways lead to the induction of the protein GADD34, which appears to provide protection against the toxic effects of the secreted virulence factors in Pseudomonas aeruginosa infection

  5. The data highlight independent interactions of PP1 (show PPA1 Proteins) and eIF2alpha (show EIF2A Proteins) with GADD34, demonstrating that GADD34 functions as a scaffold both in vitro and in cells

  6. GADD34 may play a neuroprotective role against amyloid-beta toxicity.

  7. GADD34 enhances autophagy and suppresses apoptosis stimulated by LPS (show IRF6 Proteins) combined with amino acid deprivation through regulation of mTOR (show FRAP1 Proteins) signaling pathway in macrophages.

  8. Data indicate that protein phosphatase 1 (show PPP1CB Proteins) subunit GADD34 directly interacts with eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha (show EIF2S1 Proteins)).

  9. GADD34 was increased in neurons of human Alzheimer's disease (AD) brains. Additionally, this finding was also observed in oligodendrocytes in human AD brains. GADD34 could be a therapeutic target for preventing ER stress in neuronal cells in AD.

  10. GADD34 promotes cell survival and adaptation to increased extracellular osmolarity by increasing the uptake of small neutral amino acids via the amino acid transporter (show SLC43A2 Proteins) SNAT2 (show SLC38A2 Proteins).

Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A (PPP1R15A) Protein Profile

Protein Summary

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation.

Gene names and symbols associated with PPP1R15A

  • protein phosphatase 1, regulatory subunit 15A (PPP1R15A)
  • protein phosphatase 1, regulatory (inhibitor) subunit 15A (PPP1R15A)
  • protein phosphatase 1, regulatory (inhibitor) subunit 15A (Ppp1r15a)
  • protein phosphatase 1, regulatory subunit 15A (Ppp1r15a)
  • 9630030H21 protein
  • GADD34 protein
  • Myd116 protein
  • Peg-3 protein
  • RGD1624209 protein

Protein level used designations for PPP1R15A

protein phosphatase 1, regulatory (inhibitor) subunit 15A , growth arrest and DNA damage-inducible protein GADD34 , growth arrest and DNA-damage-inducible 34 , myeloid differentiation primary response gene 116 , myeloid differentiation primary response protein MyD116 , protein phosphatase 1 regulatory subunit 15A , myeloid differentiation primary response protein MyD116 homolog , progression elevated gene 3 protein

GENE ID SPECIES
456191 Pan troglodytes
718350 Macaca mulatta
100449481 Pongo abelii
100591446 Nomascus leucogenys
17872 Mus musculus
23645 Homo sapiens
171071 Rattus norvegicus
514688 Bos taurus
476419 Canis lupus familiaris
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