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PPP1R1B encodes a bifunctional signal transduction molecule. Additionally we are shipping Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B Antibodies (218) and Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B Proteins (8) and many more products for this protein.
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DARPP-32 and I-1 were most frequently identified in dendritic shafts, unlike the D1R (show DRD1 ELISA Kits) and PP1 isoforms. Moreover, DARPP-32 and I-1 were only present in approximately 4% and 8% of area 9 pyramidal cell spines, respectively.
Study associates polymorphisms in DRD2 (show DRD2 ELISA Kits), DARPP-32, and COMT (show COMT ELISA Kits) genes with novel category learning performance. Modeling results suggest that striatal dopaminergic genes influence selective attention processes whereas cortical genes mediate the ability to update complex rule representations.
Results show that expression of human DARPP-32 protein isoforms depends on the striatal neurodevelopmental stage with t-DARPP being specific for the human adult striatum.
In vivo xenograft models demonstrated that overexpression of DARPP-32 promotes angiogenesis and tumour growth.
This study strongly suggests that inflammation-regulated DARPP-32 constitutes a key component of H. pylori-mediated gastric tumourigenesis.
DARPP-32 is mainly cleaved at Thr (show TRH ELISA Kits)(153) by calpain and this cleavage of DARPP-32 reduces CREB (show CREB1 ELISA Kits) phosphorylation via loss of its inhibitory function on PP1 (show PPA1 ELISA Kits); results suggest a novel mechanism of DARPP-32-CREB (show CREB1 ELISA Kits) signalling dysregulation in Alzheimer's disease
No significant differences in mRNA expression levels of DRD2 (show DRD2 ELISA Kits) and DARPP-32 were found among controls, patients with psychotic disorder not otherwise specified, and schizophrenia/schizophreniform disorder.
Striatal function was indexed by a gene coding for DARPP-32, which is densely expressed in the striatum where it is necessary for synaptic plasticity
Findings show that PPP1R1B-STARD3 (show STARD3 ELISA Kits) fusion transcript has a key role in subsets of gastric cancers through the activation of PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) signaling.
Results suggest that variation in PPP1R1B affects the abundance of the splice variant t-DARPP-32 mRNA and may reflect potential molecular mechanisms implicated in schizophrenia and affective disorders
The immunostaining was more decreased for DARPP-32 than for the morphological changes of striatal neurons in multiple system atrophy.
the results suggest that by inducing dephosphorylation of DARPP-32 at Ser (show SIGLEC1 ELISA Kits)-97 and altering its cytonuclear distribution, glutamate (show GRIN1 ELISA Kits) may counteract dopamine/D1 receptor (show DRD1 ELISA Kits)/PKA signaling at multiple cellular levels.
Darpp32 interaction with beta-adducin (show ADD2 ELISA Kits) may be the molecular pathway by which environmental changes may rapidly alter responsiveness of striatal neurons involved in the reward system.
Results show that Darpp-32 was expressed in normal mouse mammary tissue and in some breast tumors, whereas t-Darpp was found exclusively in mammry tumors.
analysis of cAMP-activated DARPP-32 signalling to the nucleus
Results describe the development of new vascular mouse model with a conditional knockout allele of Tsc1 (show TSC1 ELISA Kits) with a Darpp32-Cre allele. This mouse displayed accelerated formation of both kidney cystadenomas and paw hemangiosarcomas.
Cannabinoid-stimulated G-protein activity did not differ between DARPP-32 KO and WT mice treated with vehicle or repeated THC.
In this work, the dissected postsynaptic topology of the DARPP-32 phosphoprotein provides strong evidence for a compartmentalized and confined distribution in dendritic spines.
Adenosine AA receptors in striatal glutamatergic terminals and GABAergic neurons oppositely modulate psychostimulant action and DARPP-32 phosphorylation.
Data suggest that histone deacetylase (show HDAC1 ELISA Kits) inhibitors inhibit the induction of NGF1A-binding protein (show NAB1 ELISA Kits) Nab2 (show NAB2 ELISA Kits) by brain derived neurotrophic factor (BDNF (show BDNF ELISA Kits)), and thereby the relative induction of dopamine and cyclic AMP-regulated phosphoprotein (show ARPP21 ELISA Kits), 32 kDa (DARPP-32).
Areas of brain and spinal cord that are densely innervated by tyrosine hydroxylase (show TH ELISA Kits)-immunoreactive fibers display a remarkable immunoreactivity for DARPP-32/ppp1r1b in cell bodies and neuropil.
This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene.
protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32)
, neuronal phosphoprotein DARPP-32
, protein phosphatase 1 regulatory subunit 1B
, protein phosphatase 1, regulatory (inhibitor) subunit 1B
, dopamine- and cAMP-regulated neuronal phosphoprotein
, dopamine- and cAMP-regulated phosphoprotein DARPP-32
, dopamine and cAMP-regulated neuronal phosphoprotein 32
, dopamine and cAMP regulated