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IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53\; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008].. Additionally we are shipping Protein Phosphatase 1, Regulatory Subunit 13 Like Antibodies (64) and Protein Phosphatase 1, Regulatory Subunit 13 Like Kits (2) and many more products for this protein.
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miR (show MLXIP Proteins)-182 plays an aggressive role in the cerebral ischemia injury, and this is associated with inhibited iASPP expression.
iASPP expression may act as a predictive marker of prostate cancer progression.
These data demonstrate that by interacting with desmoplakin and desmin (show DES Proteins), iASPP is an important regulator of desmosomal function both in vitro and in vivo.
p53 (show TP53 Proteins)-mediated neuronal cell death after stroke can be nontranscriptionally regulated by a novel mechanism involving suppression of endogenous cell death inhibitors by miR (show MLXIP Proteins)-124.
PPP1R13L has an essential role in embryonic eyelid closure as well in development of meibomian glands and the anterior segment of the eye
These data showed iASPP to be a key regulator of epithelial homeostasis in skin.
Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification.
Mice with mutation in Nkip1 (Ppp1r13l) represent a potentially important model for the analysis of the role of inflammatory processes in heart disease.
Studies revealed that overexpression of PPP1R13L causes faster p53 (show TP53 Proteins) degradation, a likely explanation for the depletion of p53 (show TP53 Proteins).
We describe the identification of a maternally inherited frameshift mutation in RAI1 (show DOM3Z Proteins), causative for SMS (show SMS Proteins). This is the first report about transmission of SMS (show SMS Proteins) from an affected parent to an offspring.
These results determined PPP1R13L as the gene underlying a novel autosomal-recessive cardio-cutaneous syndrome in humans and strongly suggest that the fatal dilated cardiomyopathy during infancy is a consequence of failure to regulate transcriptional pathways necessary for tuning cardiac threshold response to common inflammatory stressors.
UCA1 might promote proliferation and migration of glioma, to regulate the tumor growth and metastasis via miR (show MLXIP Proteins)-182 dependent iASPP regulation.
Results demonstrate that iASPP is overexpressed in bladder cancer and promotes the malignancy of bladder cancer
lncRNA H19 (show NCKAP1 Proteins) interacts with miR (show MLXIP Proteins)-140 to modulate glioma growth by targeting iASPP
Increased expression of p53 (show TP53 Proteins) and ASPP1 (show PPP1R13B Proteins) and downregulation of iASPP.
Our study provides the first evidence that high iASPP-SV expression may be a novel prognostic factor and therapeutic target for glioma
we were able to reproduce previously found associations between PPP1R13L and CD3EAP (show CD3EAP Proteins) polymorphisms and lung cancer risk in an increased study group, and we found interactions between NFKB1 (show NFKB1 Proteins) rs28362491-PPP1R13L rs1970764 and smoking duration and between CD3EAP (show CD3EAP Proteins) rs735482 and smoking duration
inhibitor of apoptosis-stimulating protein of p53 (iASPP) was identified to be a direct target of miR (show MLXIP Proteins)-140 in pancreatic duct adenocarcinoma specimens and cell lines
we show that iASPP is a novel substrate of caspases in response to apoptotic stimuli
Frameshift mutation in PPP1R13L causes Cardiomyopathy and woolly haircoat syndrome in Poll Hereford cattle.
Data suggest Greatwall (show MASTL Proteins) kinase (Gwl (show MASTL Proteins)) associates with protein phosphatase 1 (show PPP1CB Proteins) (PP1 (show PPYR1 Proteins)), particularly PP1gamma subunit, which mediates dephosphorylation of Gwl (show MASTL Proteins) Ser (show SIGLEC1 Proteins)-883; consistent with mitotic activation of Gwl (show MASTL Proteins), its association with PP1 (show PPYR1 Proteins) is disrupted in mitotic cells; subunits PPP1R3B (show PPP1R3B Proteins) and PPP1R13L associate with Gwl (show MASTL Proteins); thus, PPP1R3B (show PPP1R3B Proteins) appears to act as cell cycle regulator in oocytes that functions by governing Gwl (show MASTL Proteins) dephosphorylation.
IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53\; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.
NFkB interacting protein 1
, NFkB-interacting protein 1
, PPP1R13B-like protein
, inhibitor of ASPP protein
, protein iASPP
, relA-associated inhibitor
, inhibitor of apoptosis stimulating protein of p53
, protein phosphatase 1, regulatory (inhibitor) subunit 13 like
, retinoic acid induced 4