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Protein Phosphatase 1, Regulatory Subunit 15B Proteins (PPP1R15B)

PPP1R15B promotes dephosphorylation of the transcription initiation factor EIF2-alpha (EIF2S1\; MIM 603907) through recruitment of protein phosphatase-1 (PP1) catalytic subunits (see MIM 176875) (Harding et al., 2009 [PubMed 19181853]).[supplied by OMIM, Feb 2010].. Additionally we are shipping Protein Phosphatase 1, Regulatory Subunit 15B Antibodies (27) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PPP1R15B 108954 Q8BFW3
PPP1R15B 84919 Q5SWA1
Rat PPP1R15B PPP1R15B 304799  
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Top Protein Phosphatase 1, Regulatory Subunit 15B Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details

PPP1R15B Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human

More Proteins for Protein Phosphatase 1, Regulatory Subunit 15B (PPP1R15B) Interaction Partners

Mouse (Murine) Protein Phosphatase 1, Regulatory Subunit 15B (PPP1R15B) interaction partners

  1. CReP expression was markedly suppressed in XBP1 (show XBP1 Proteins)-deficient mice livers due to hyperactivated Ire1alpha (show ERN1 Proteins).

  2. Ppp1r15a (show PPP1R15A Proteins) mutant mice are superficially indistinguishable from wild type; Ppp1r15b(-/-) mouse embryos survive gestation but exhibit severe growth retardation and impaired erythropoiesis, and loss of both Ppp1r15 genes leads to early embryonic lethality

Human Protein Phosphatase 1, Regulatory Subunit 15B (PPP1R15B) interaction partners

  1. Whole-exome sequencing identified a homozygous missense mutation, c.1972G>A; p.Arg658Cys, in protein phosphatase 1 (show PPP1CB Proteins), regulatory subunit 15b (PPP1R15B)

  2. the first homozygous mutation in the PPP1R15B gene encoding the regulatory subunit of an eIF2alpha (show EIF2A Proteins)-specific phosphatase in two siblings affected by a novel syndrome of diabetes of youth with short stature, intellectual disability, and microcephaly

  3. CIP2A (show KIAA1524 Proteins) regulates cancer metabolism and CREB (show CREB1 Proteins) phosphorylation in non-small cell lung cancer

  4. the mammalian traffic machinery co-opts p-eIF2alpha (show EIF2A Proteins) and CReP, regulators of translation initiation.

Protein Phosphatase 1, Regulatory Subunit 15B (PPP1R15B) Protein Profile

Protein Summary

PPP1R15B promotes dephosphorylation of the transcription initiation factor EIF2-alpha (EIF2S1\; MIM 603907) through recruitment of protein phosphatase-1 (PP1) catalytic subunits (see MIM 176875) (Harding et al., 2009

Gene names and symbols associated with PPP1R15B

  • protein phosphatase 1, regulatory (inhibitor) subunit 15b (Ppp1r15b)
  • protein phosphatase 1, regulatory subunit 15B (PPP1R15B)
  • protein phosphatase 1, regulatory subunit 15B (Ppp1r15b)
  • 1810033K10Rik protein
  • AI606441 protein
  • C530022L24Rik protein
  • CREP protein

Protein level used designations for PPP1R15B

constitutive repressor of eIF2alpha phosphorylation , protein phosphatase 1 regulatory subunit 15B , protein phosphatase 1, regulatory (inhibitor) subunit 15B , protein phosphatase 1, regulatory (inhibitor) subunit 15b

GENE ID SPECIES
108954 Mus musculus
84919 Homo sapiens
304799 Rattus norvegicus
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