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Protein Phosphatase 1, Regulatory Subunit 8 Proteins (PPP1R8)

PPP1R8, through alternative splicing, encodes three different isoforms. Additionally we are shipping Protein Phosphatase 1, Regulatory Subunit 8 Antibodies (96) and Protein Phosphatase 1, Regulatory Subunit 8 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PPP1R8 8260 P41227
PPP1R8 100336 Q8R3G1
Rat PPP1R8 PPP1R8 313030  
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Top Protein Phosphatase 1, Regulatory Subunit 8 Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,955.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$382.86
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PPP1R8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Top referenced Protein Phosphatase 1, Regulatory Subunit 8 Proteins

  1. Human PPP1R8 Protein expressed in Escherichia coli (E. coli) - ABIN1098389 : Beullens, Vulsteke, Van Eynde, Jagiello, Stalmans, Bollen: The C-terminus of NIPP1 (nuclear inhibitor of protein phosphatase-1) contains a novel binding site for protein phosphatase-1 that is controlled by tyrosine phosphorylation and RNA binding. in The Biochemical journal 2001 (PubMed)
    Show all 2 references for ABIN1098389

More Proteins for Protein Phosphatase 1, Regulatory Subunit 8 (PPP1R8) Interaction Partners

Human Protein Phosphatase 1, Regulatory Subunit 8 (PPP1R8) interaction partners

  1. Human Naa15 (NATH (show NAA15 Proteins)) and Naa10 (ARD1 (show ARD1A Proteins)) form a stable NatA complex which associates with ribosomes and performs co-translational N-terminal acetylation; Naa15 (NATH (show NAA15 Proteins)) and Naa10 (ARD1 (show ARD1A Proteins)) are cleaved during apoptosis resulting in decreased acetyltransferase activity

  2. The clinical spectrum of NAA10 (show ARD1A Proteins).

  3. there is no difference in lysine acetylation of substrate proteins with or without Naa10 (show ARD1A Proteins), suggesting that the substrates may be acetylated chemically rather than enzymatically.

  4. Combined high expression of Naa10p, SNCG (show SNCG Proteins) and PRL-3 are associated with lymph node metastasis in breast cancer.

  5. De novo missense mutations in the NAA10 (show ARD1A Proteins) gene cause severe non-syndromic developmental delay in males and females

  6. human ARD1 (show TRIM23 Proteins) variants have different effects on cell proliferation, which may result from distinct subcellular localizations and autoacetylation activities.

  7. Naa10 (show ARD1A Proteins) structure and function. [Review]

  8. Autoacetylation of ARD1 (show TRIM23 Proteins) variants differentially regulates angiogenesis and cell proliferation in an isoform-specific manner.

  9. Data suggest overexpression of NIPP1 in HeLa cells causes induction of genes of mesenchymal lineage with reduction in cell proliferation; thus, key dephosphorylation events may be involved in epithelial-mesenchymal transition or transdifferentiation.

  10. ARD1 (show TRIM23 Proteins) has a crucial role in the cellular response to oxidative stress as a bona fide regulator of MSRA (show MSRA Proteins).

Mouse (Murine) Protein Phosphatase 1, Regulatory Subunit 8 (PPP1R8) interaction partners

  1. activation of the RAGE (show AGER Proteins) by advanced glycation end products or other ligands suppresses NIPP1 expression in diabetic nephropathy, contributes to podocyte hypertrophy, and glomerular inflammation

  2. NIPP1(-/-) embryos showed severely retarded growth at embryonic day 6.5 (E6.5) and were resorbed by E8.5. This early embryonic lethality was not associated with increased apoptosis but correlated with impaired cell proliferation.

  3. NIPP1 has a role in the nuclear targeting and/or retention of PP1 (show PPP1CC Proteins)

  4. Required for the global trimethylation of Histone 3 at Lysine 27 and is implicated in gene silencing by enhancer of zeste homolog (EZH)2 (show EZH2 Proteins).

Protein Phosphatase 1, Regulatory Subunit 8 (PPP1R8) Protein Profile

Protein Summary

This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.

Gene names and symbols associated with PPP1R8

  • N(alpha)-acetyltransferase 10, NatA catalytic subunit (NAA10)
  • protein phosphatase 1, regulatory (inhibitor) subunit 8 (Ppp1r8)
  • protein phosphatase 1, regulatory subunit 8 (PPP1R8)
  • protein phosphatase 1, regulatory subunit 8 (ppp1r8)
  • protein phosphatase 1, regulatory subunit 8 (Ppp1r8)
  • zgc:63827 (zgc:63827)
  • 6330548N22Rik protein
  • ARD-1 protein
  • ard1 protein
  • ARD1A protein
  • AU044684 protein
  • DXS707 protein
  • NATD protein
  • NIPP-1 protein
  • nipp1 protein
  • PPP1R8 protein
  • PRO2047 protein
  • TE2 protein

Protein level used designations for PPP1R8

ARD1 homolog A, N-acetyltransferase , N-acetyltransferase ARD1, human homolog of , N-alpha-acetyltransferase 10 , N-alpha-acetyltransferase 10, NatA catalytic subunit , N-terminal acetyltransferase complex ARD1 subunit homolog A , NIPP-1 , nuclear inhibitor of protein phosphatase 1 , protein phosphatase 1 regulatory inhibitor subunit 8 , protein phosphatase 1, regulatory (inhibitor) subunit 8 , protein phosphatase 1, regulatory inhibitor subunit 8 , RNase E , activator of RNA decay , nuclear inhibitor of protein phosphatase-1 alpha , nuclear subunit of PP-1 , protein phosphatase 1 regulatory subunit 8 , uncharacterized protein LOC799896

GENE ID SPECIES
8260 Homo sapiens
100336 Mus musculus
282319 Bos taurus
398974 Xenopus laevis
419564 Gallus gallus
5511 Homo sapiens
487340 Canis lupus familiaris
313030 Rattus norvegicus
799896 Danio rerio
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