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Protein Phosphatase 1, Regulatory Subunit 9B, Spinophilin Proteins (PPP1R9B)

Spinophilin is a regulatory subunit of protein phosphatase-1 catalytic subunit (PP1\; see MIM 176875) and is highly enriched in dendritic spines, specialized protrusions from dendritic shafts that receive most of the excitatory input in the central nervous system (Allen et al., 1997 [PubMed 9275233]).[supplied by OMIM, Mar 2008].. Additionally we are shipping Protein Phosphatase 1, Regulatory Subunit 9B, Spinophilin Antibodies (47) and Protein Phosphatase 1, Regulatory Subunit 9B, Spinophilin Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat PPP1R9B PPP1R9B 84686 O35274
PPP1R9B 84687 Q96SB3
PPP1R9B 217124 Q6R891
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Top Protein Phosphatase 1, Regulatory Subunit 9B, Spinophilin Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PPP1R9B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Protein Phosphatase 1, Regulatory Subunit 9B, Spinophilin (PPP1R9B) Interaction Partners

Human Protein Phosphatase 1, Regulatory Subunit 9B, Spinophilin (PPP1R9B) interaction partners

  1. Low spinophilin expression enhances aggressive biological behavior of breast cancer.

  2. Colorectal carcinoma expression of spinophilin expression determines cellular growth, cancer stemness and 5-flourouracil resistance.

  3. spinophilin might play a previously unrecognized role in the pathogenesis of head and neck squamous cell carcinoma

  4. Spn (show SPN Proteins) downregulation contributes to a more aggressive biologic behavior, induces chemoresistance, and is associated with a poorer survival in patients with advanced stages of colorectal carcinoma.

  5. study found a substantial number of hepatocellular carcinomas (HCC (show FAM126A Proteins)) show reduced or absent Spn (show SPN Proteins) expression; the low expression of Spn (show SPN Proteins) in tumour tissue is an independent negative prognostic factor for clinical outcome in HCC (show FAM126A Proteins); spinophilin expression inversely correlates with proliferative activity

  6. Studies suggest that any change in substrate specificity of the spinophilin : PP1 (show PPA1 Proteins) holoenzyme complex was probably due to direct modification of a PP1 (show PPA1 Proteins) substrate binding surface.

  7. Spinophilin associates with both delta- and mu-OmicronR and G protein subunits in HEK293 cells participating in a multimeric signaling complex that displays a differential regulatory role in opioid receptor signaling.

  8. Spinophilin-deficient mice have enhanced antidepressant response to desipramine compared with wild-type controls.

  9. Data show that that SPL/RGS/SHP1 complexes are present in resting platelets where constitutive phosphorylation of SPL(Y398) creates an atypical binding site for SHP-1.

  10. The molecular size and subcellular location of myotube glycogen (show GYS1 Proteins) particles is determined by the PPP1R6, PTG (show PPP1R3C Proteins) and G(M) scaffolding.

Mouse (Murine) Protein Phosphatase 1, Regulatory Subunit 9B, Spinophilin (PPP1R9B) interaction partners

  1. COPS5 (show COPS5 Proteins) overexpression reduced spinophilin in both the cortex (19%, p < 0.05) and the hippocampus (20%, p < 0.05), leading to significant deficits in learning and memory skills

  2. RanBP9 (show RANBP9 Proteins) overexpression in transgenic mice led to striking reduction in the levels of spinophilin.

  3. Canonical betaAR-mediated signaling coupled to PKA activation results in phosphorylation of spinophilin, disrupting its interaction with alpha2AARs and accelerating alpha2AAR (show ADRA2A Proteins) endocytic responses.

  4. Findings support the concept that the inhibitory effects of SPL (show SGPL1 Proteins) on M3R (show CHRM3 Proteins) activity are mediated by RGS4 (show RGS4 Proteins).

  5. changes in spinophilin/CaMKII (show CAMK2G Proteins) interactomes may contribute to changes in striatal dendritic spine density, morphology, and function during normal postnatal maturation and aging.

  6. these data suggest that spinophilin is an upstream regulator required for normal growth and excitation-contraction coupling, but is dispensable for beta-adrenergic stimulation of adult cardiomyocytes.

  7. Findings suggest that spinophilin restrains Angiotensin II-mediated sympathetic nervous system activation and is an unrecognized molecule with regard to central blood pressure control

  8. We suggest that Spn (show SPN Proteins) may be the tumor suppressor gene located at 17q21.33 acting through Rb regulation.

  9. the combined loss of Spn (show SPN Proteins) and mutant p53 (show TP53 Proteins) activity led to increased mammary carcinomas, confirming the functional relationship between p53 (show TP53 Proteins) and Spn (show SPN Proteins).

  10. IRSp53 (show BAIAP2 Proteins) and spinophilin regulate localized Rac (show AKT1 Proteins) activation by T-lymphocyte invasion and metastasis protein 1

Protein Phosphatase 1, Regulatory Subunit 9B, Spinophilin (PPP1R9B) Protein Profile

Protein Summary

Spinophilin is a regulatory subunit of protein phosphatase-1 catalytic subunit (PP1\; see MIM 176875) and is highly enriched in dendritic spines, specialized protrusions from dendritic shafts that receive most of the excitatory input in the central nervous system (Allen et al., 1997

Gene names and symbols associated with PPP1R9B

  • protein phosphatase 1, regulatory subunit 9B (Ppp1r9b)
  • protein phosphatase 1, regulatory subunit 9B (PPP1R9B)
  • Neb2 protein
  • PPP1R6 protein
  • PPP1R9 protein
  • SPINO protein
  • SPL protein
  • Spn protein

Protein level used designations for PPP1R9B

PP1bp134 , neurabin 2 , neurabin-2 , neurabin-II , neural tissue-specific F-actin-binding protein II , nuerabin 2 , p130 , spinophilin , neurabin II , protein phosphatase 1, regulatory (inhibitor) subunit 9B , protein phosphatase 1, regulatory subunit 9B, spinophilin

GENE ID SPECIES
84686 Rattus norvegicus
84687 Homo sapiens
217124 Mus musculus
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