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Spinophilin is a regulatory subunit of protein phosphatase-1 catalytic subunit (PP1; see MIM 176875) and is highly enriched in dendritic spines, specialized protrusions from dendritic shafts that receive most of the excitatory input in the central nervous. Additionally we are shipping Protein Phosphatase 1, Regulatory Subunit 9B, Spinophilin Kits (7) and Protein Phosphatase 1, Regulatory Subunit 9B, Spinophilin Proteins (4) and many more products for this protein.
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Human Polyclonal PPP1R9B Primary Antibody for EIA, WB - ABIN953658
Sagara, Kawasaki, Iemura, Natsume, Takai, Akiyama: Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration. in Oncogene 2009
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Low spinophilin expression enhances aggressive biological behavior of breast cancer.
Colorectal carcinoma expression of spinophilin expression determines cellular growth, cancer stemness and 5-flourouracil resistance.
spinophilin might play a previously unrecognized role in the pathogenesis of head and neck squamous cell carcinoma
Spn (show SPN Antibodies) downregulation contributes to a more aggressive biologic behavior, induces chemoresistance, and is associated with a poorer survival in patients with advanced stages of colorectal carcinoma.
study found a substantial number of hepatocellular carcinomas (HCC (show FAM126A Antibodies)) show reduced or absent Spn (show SPN Antibodies) expression; the low expression of Spn (show SPN Antibodies) in tumour tissue is an independent negative prognostic factor for clinical outcome in HCC (show FAM126A Antibodies); spinophilin expression inversely correlates with proliferative activity
Studies suggest that any change in substrate specificity of the spinophilin : PP1 (show PPA1 Antibodies) holoenzyme complex was probably due to direct modification of a PP1 (show PPA1 Antibodies) substrate binding surface.
Spinophilin associates with both delta- and mu-OmicronR and G protein subunits in HEK293 cells participating in a multimeric signaling complex that displays a differential regulatory role in opioid receptor signaling.
Spinophilin-deficient mice have enhanced antidepressant response to desipramine compared with wild-type controls.
Data show that that SPL/RGS/SHP1 complexes are present in resting platelets where constitutive phosphorylation of SPL(Y398) creates an atypical binding site for SHP-1.
The molecular size and subcellular location of myotube glycogen (show GYS1 Antibodies) particles is determined by the PPP1R6, PTG (show PPP1R3C Antibodies) and G(M) scaffolding.
COPS5 (show COPS5 Antibodies) overexpression reduced spinophilin in both the cortex (19%, p < 0.05) and the hippocampus (20%, p < 0.05), leading to significant deficits in learning and memory skills
RanBP9 (show RANBP9 Antibodies) overexpression in transgenic mice led to striking reduction in the levels of spinophilin.
Canonical betaAR-mediated signaling coupled to PKA activation results in phosphorylation of spinophilin, disrupting its interaction with alpha2AARs and accelerating alpha2AAR (show ADRA2A Antibodies) endocytic responses.
Findings support the concept that the inhibitory effects of SPL (show SGPL1 Antibodies) on M3R (show CHRM3 Antibodies) activity are mediated by RGS4 (show RGS4 Antibodies).
changes in spinophilin/CaMKII (show CAMK2G Antibodies) interactomes may contribute to changes in striatal dendritic spine density, morphology, and function during normal postnatal maturation and aging.
these data suggest that spinophilin is an upstream regulator required for normal growth and excitation-contraction coupling, but is dispensable for beta-adrenergic stimulation of adult cardiomyocytes.
Findings suggest that spinophilin restrains Angiotensin II-mediated sympathetic nervous system activation and is an unrecognized molecule with regard to central blood pressure control
We suggest that Spn (show SPN Antibodies) may be the tumor suppressor gene located at 17q21.33 acting through Rb regulation.
the combined loss of Spn (show SPN Antibodies) and mutant p53 (show TP53 Antibodies) activity led to increased mammary carcinomas, confirming the functional relationship between p53 (show TP53 Antibodies) and Spn (show SPN Antibodies).
IRSp53 (show BAIAP2 Antibodies) and spinophilin regulate localized Rac (show AKT1 Antibodies) activation by T-lymphocyte invasion and metastasis protein 1
Spinophilin is a regulatory subunit of protein phosphatase-1 catalytic subunit (PP1\; see MIM 176875) and is highly enriched in dendritic spines, specialized protrusions from dendritic shafts that receive most of the excitatory input in the central nervous system (Allen et al., 1997
, neurabin 2
, neural tissue-specific F-actin-binding protein II
, nuerabin 2
, neurabin II
, protein phosphatase 1, regulatory (inhibitor) subunit 9B
, protein phosphatase 1, regulatory subunit 9B, spinophilin