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The protein encoded by PPP2R4 is a member of the protein tyrosine phosphatase (PTP) family.
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Evidence for PPP2R4 as a haploinsufficient tumor suppressor gene, defining a high-penetrance genetic mechanism for PP2A (show PPP2R2B Antibodies) inhibition in human cancer.
data indicate that PTPalpha (show PTPRA Antibodies) and FAK (show PTK2 Antibodies), which are enriched in FAs (show FAS Antibodies), interact with IP3R1 (show ITPR1 Antibodies) at adjacent ER sites to spatially sequester IL-1 (show IL1A Antibodies)-induced Ca(2 (show CA2 Antibodies)+) signalling
findings show that ectopic expression of the phosphotyrosyl phosphatase activator PTPA induces cell death in mammalian cells via a mechanism involving caspase-3 (show CASP3 Antibodies)-dependent apoptosis
oxidative stress regulates the phosphorylation status of nonribosomal rpS3 (show RPS3 Antibodies) by both activating PKCdelta (show PKCd Antibodies) and blocking the PP2A (show PPP2R2B Antibodies) interaction with rpS3 (show RPS3 Antibodies)
VacA mediates CagA (show S100A8 Antibodies) phosphorylation through RPTPalpha (show PTPRA Antibodies) in AZ-521 cells.
A receptor type-protein tyrosine phosphatase alpha (show PTPRA Antibodies)-Src (show SRC Antibodies) family kinase-Rap1 (show RABGEF1 Antibodies) pathway was identified as responsible for recruiting myosin IIB (show MYH10 Antibodies) to the zonula adherens in epithelial cells and supporting contractile tension.
no evidence was seen for the association of rare, missense mutations in the PTPRA (show PTPRA Antibodies) gene with schizophrenia or autism spectrum disorders
Data indicate that scaffold protein (show HOMER1 Antibodies) RACK1 (show GNB2L1 Antibodies) plays a role in IGF-1 (show IGF1 Antibodies)-mediated protein-tyrosine phosphatase alpha (PTPalpha (show PTPRA Antibodies)) tyrosine phosphorylation in MCF-7 Cells.
recruited to epithelial adherens junctions for cadherin-dependent cell adhesion and tissue architecture formation
Results suggest that inhibition of PTPalpha (show PTPRA Antibodies) can have a beneficial effect on HER2 (show ERBB2 Antibodies)-positive breast cancers, but that inhibition of additional targets is needed to block breast tumorigenesis.
new role for PTPalpha (show PTPRA Antibodies) in the regulation of motility of mammary epithelial cells in response to ErbB2 (show ERBB2 Antibodies) activation.
results suggest that PTPalpha (show PTPRA Antibodies) links activation of epidermal growth factor receptor (EGFR (show EGFR Antibodies)) signaling with Src (show SRC Antibodies) activation and may provide a novel therapeutic target for treatment of breast cancer.
A single-nucleotide polymorphism (rs6138953) on the PTPRA (show PTPRA Antibodies) gene in the 20p13 region was found to be associated with elevated fasting glucose level.
The extracellular proteolytic processing is a novel mechanism for PTPalpha (show PTPRA Antibodies) regulation.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported.
PP2A, subunit B', PR53 isoform
, phosphotyrosyl phosphatase activator
, serine/threonine-protein phosphatase 2A activator
, serine/threonine-protein phosphatase 2A regulatory subunit 4
, serine/threonine-protein phosphatase 2A regulatory subunit B'
, Leukocyte common antigen-related peptide (protein tyrosine phosphate)
, PTPLCA-related phosphatase
, protein tyrosine phosphatase, receptor type, alpha polypeptide
, protein-tyrosine phosphatase alpha
, receptor-type tyrosine-protein phosphatase alpha
, tyrosine phosphatase alpha