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PPP4R1 encodes one of several alternate regulatory subunits of serine\\/threonine protein phosphatase 4 (PP4). Additionally we are shipping Protein Phosphatase 4, Regulatory Subunit 1 Antibodies (21) and Protein Phosphatase 4, Regulatory Subunit 1 Proteins (4) and many more products for this protein.
PP4R1 could mediate the dephosphorylation of TRAF2 (show TRAF2 ELISA Kits) Ser11.
PP4R1 expression was triggered upon activation and proliferation of primary human T lymphocytes and deficiency for PP4R1 caused sustained and increased IKK (show CHUK ELISA Kits) activity, T cell hyperactivation, and aberrant NF-kappaB (show NFKB1 ELISA Kits) signaling in NF-kappaB (show NFKB1 ELISA Kits)-addicted T cell lymphomas
This gene encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4). The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a distinct role from other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants.
protein phosphatase 4, regulatory subunit 1
, serine/threonine phosphatase 4
, serine/threonine-protein phosphatase 4 regulatory subunit 1