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PPP5C encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Additionally we are shipping Protein Phosphatase 5, Catalytic Subunit Proteins (5) and Protein Phosphatase 5, Catalytic Subunit Kits (1) and many more products for this protein.
Showing 10 out of 162 products:
Dog (Canine) Monoclonal PPP5C Primary Antibody for IF, WB - ABIN968321
Becker, Kentrup, Klumpp, Schultz, Joost: Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain. in The Journal of biological chemistry 1994
Show all 5 Pubmed References
Dog (Canine) Monoclonal PPP5C Primary Antibody for IF, WB - ABIN968322
Chen, McPartlin, Brown, Chen, Barker, Cohen: A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus. in The EMBO journal 1994
Show all 5 Pubmed References
Human Polyclonal PPP5C Primary Antibody for IF, WB - ABIN519138
Williams, Filter, Blake-Hodek, Wadzinski, Fuda, Shalloway, Goldberg: Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers. in eLife 2014
Human Polyclonal PPP5C Primary Antibody for IHC (p), IP - ABIN258197
Lai, OCallaghan, Zoghbi, Orr: 14-3-3 Binding to ataxin-1(ATXN1) regulates its dephosphorylation at Ser-776 and transport to the nucleus. in The Journal of biological chemistry 2011
Our results showed 1) a critical role for PP5 in cytokine-induced resistance to GC-mediated eosinophil death, 2) supported the dependence of GCR (show NR3C1 Antibodies) phosphorylation on PP5 activity, and 3) revealed that PP5 is a target of the lipoxin A4-induced pathway countering cytokine-induced resistance to GCs (show GCLC Antibodies) in eosinophils.
our research indicated that miR (show MLXIP Antibodies)-130a functions as an oncogene (show RAB1A Antibodies) by targeting TFPI2 (show TFPI2 Antibodies), miR (show MLXIP Antibodies)-130a inhibition reduced the growth and angiogenesis of hemangioma by inactivating the FAK (show PTK2 Antibodies)/PI3K (show PIK3CA Antibodies)/Rac1/mdm2 (show MDM2 Antibodies) pathway
TFPI-2 (show TFPI2 Antibodies) expression was decreased in bladder cancer. TFPI-2 (show TFPI2 Antibodies) expression was decreased with progression in tumor grade and stage and was correlated to decreased apoptosis.
TFPI2 (show TFPI2 Antibodies) is a useful serum biomarker for preoperative clinical diagnosis of CCC.
This TPR-dependent PP5 inhibition shown by Ro 90-7501 is a unique and novel inhibitory mechanism, which might be a useful tool for studies of PP5 on both regulatory mechanism and drug discovery.
Over-expression of TFPI-2 (show TFPI2 Antibodies) and aberrant promoter methylation status presented in the preeclampsia placentas, suggesting that epigenetic mechanism might contribute to the pathogenesis of preeclampsia.
Data show that silencing tumor-endothelial cells (EC) for trypsinogen 4 (show PRSS3 Antibodies) accumulated tissue factor pathway inhibitor-2 (TFPI-2 (show TFPI2 Antibodies)) in the matrix.
the importance of PP5 in CRC (show CALR Antibodies) cell growth
PPP5C could be essential for glioma cell growth.
Hypermethylation of TFPI2 (show TFPI2 Antibodies) promoter is increased in inflamed colon tissue.
PP5 is a unique phosphatase reciprocally regulating PPARgamma (show PPARG Antibodies) and RUNX2 (show RUNX2 Antibodies) activities in marrow mesenchymal stem cell
Mice with inactivated protein phosphatase 5 have decreased adipogenesis.
Ppp5c- knockout mice are resistant to weight gain induced by high fat diet.
Chp-1 (show CHORDC1 Antibodies) and melusin (show ITGB1BP2 Antibodies) can interact with cochaperones PP5 and Sgt1 (show SUGT1 Antibodies) and with each other in an ATP-dependent manner
PP5 regulates the TGFbeta (show TGFB1 Antibodies) pathway in MEFs by regulating the expression of SMAD3 (show SMAD3 Antibodies) protein levels.
Data show that protein phosphatase 5 (PP5), a nuclear receptor co-chaperone, reciprocally modulates the lipometabolic activities of GRalpha and PPARgamma.
genetic disruption of PP5 is associated with enhanced and prolonged phosphorylation of a single serine (Ser (show SIGLEC1 Antibodies)-345) on Chk1 (show CHEK1 Antibodies)
Constitutive over expression of serine/threonine protein phosphatase 5 augments estrogen-dependent tumor growth in mice
tau is probably a physiological substrate of protein phosphatase 5 (PP5) and that the abnormal hyperphosphorylation of tau in Alzheimer disease might result in part from the decreased PP5 activity in the diseased brains
Data suggest that endogenous protein phosphatase 5 can exert a negative modulatory effect on basal ACTH (show POMC Antibodies) release in neurosecretion-competent AtT20 cells.
This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants.
serine/threonine-protein phosphatase 5
, protein phosphatase 5, catalytic subunit
, serine/threonine-protein phosphatase 5-like
, protein phosphatase T
, ANP receptor
, placental protein 5
, retinal pigment epithelium cell factor 1