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PPP6C encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Additionally we are shipping Protein Phosphatase 6, Catalytic Subunit Proteins (5) and many more products for this protein.
Showing 10 out of 73 products:
Human Polyclonal PPP6C Primary Antibody for IP, WB - ABIN251362
Douglas, Zhong, Ye, Moorhead, Xu, Lees-Miller: Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX. in Molecular and cellular biology 2010
Show all 4 Pubmed References
Knockdown of Alpha4 preferentially impacts the expression of PP4c (show PPP4C Antibodies) and PP6c compared to expression levels of PP2Ac (show PPP2CA Antibodies).
findings suggest that BRCA1 is a novel modulator of PP6 signalling via its interaction with ANKRD28 (show ANKRD28 Antibodies).
Data show 408 phosphopeptides on 272 proteins that increased and 298 phosphopeptides on 220 proteins that decreased in phosphorylation upon catalytic subunit of rotein phosphatase 6 (PP6c) depletion in mitotic cells.
Protein phosphatase 6 ( (show NFKB1 Antibodies)ppp6c), a ne (show MLXIP Antibodies)gative regulator that restricts the G1 to S phase progression, is diminished in human psoriatic epidermis and is directly targeted by miR-31.
PP6 is involved in a diverse set of biological pathways.
These results suggest that human PP6 interacts with and positively regulates the activity of the influenza A virus RNA-dependent RNA polymerase.
PP6C mutations have distinct functional and clinical consequences in melanoma, and confer sensitivity to Aurora A kinase (show AURKA Antibodies) inhibitors.
PP6c associates with E-cadherin (show CDH1 Antibodies) in adherens junctions and is required to oppose casein kinase-1 (show CSNK1A1 Antibodies) to maintain cell surface localization of E-cadherin (show CDH1 Antibodies).
Findings support the view that formation of micronuclei rather than chromosome instability alone explains how loss of PPP6C, and more generally mitotic spindle and centrosome defects, can act as drivers for genome instability in melanoma.
Results show that Sit4p and its mammalian orthologue, PP6, regulate traffic from the ER to the Golgi complex which is consistent with its role in coat recycling.
the Ppp6c phosphatase domain is indispensable for mouse embryogenesis after implantation.
findings uncover a hitherto unknown role for PP6 as an indispensable regulator of oocyte meiosis and female fertility.
Data identify NF-kappaB (show NFKB1 Antibodies)-induced miR (show MLXIP Antibodies)-31 and its target, ppp6c, as critical factors for the hyperproliferation of epidermis in psoriasis.
Ppp6c deficiency predisposes mice to skin carcinogenesis initiated by DMBA.
Ppp6c deficiency underlies molecular events that drive outgrowth of initiated keratinocytes harboring UVB-induced mutated p53 (show TP53 Antibodies)
Our studies demonstrate that PP6 acts as a critical negative regulator of naive T cell homeostasis
PP6 regulates the sensitivity of GBM cells to radiation, and suggest small molecules disrupting or inhibiting PP6 association with DNA-PK is a potential radiosensitizer for GBM.
alpha4 expression differentially increased or decreased phosphorylation of endogenous phosphoproteins, consistent with opposing effects on PP2A (show PPP2R2B Antibodies) and PP6 [PP6]
This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X.
, protein phosphatase V
, protein phosphatase 6, catalytic subunit
, serine/threonine-protein phosphatase 6 catalytic subunit
, serine/threonine-protein phosphatase 6 catalytic subunit-like
, serine/threonine protein phosphatase catalytic subunit