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PRC1 encodes a protein that is involved in cytokinesis. Additionally we are shipping PRC1 Proteins (5) and PRC1 Kits (2) and many more products for this protein.
Showing 10 out of 84 products:
Human Monoclonal PRC1 Primary Antibody for BCA - ABIN2665339
Jiang, Jimenez, Wells, Hope, Wahl, Hunter, Fukunaga: PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis. in Molecular cell 1999
Show all 2 references for ABIN2665339
Results mechanistically explain how the two conserved, essential midzone proteins PRC1 and Xklp1 cooperate to constitute a minimal protein module capable of dynamically organizing the core structure of the central anaphase spindle.
PP2A (show PPP2R4 Antibodies)-B55 (show MINK1 Antibodies) dephosphorylates PRC1 at the metaphase to anaphase transition. This activity is regulated by the Greatwall (MASTL (show MASTL Antibodies)) kinase and its substrate ENSA (show ENSA Antibodies), explaining the timing of PRC1 activation in anaphase.
PRC1 complexes isolated from human cells contain multiple kinesins KIF4A (show KIF4A Antibodies), Kif20A (show KIF20A Antibodies), KIF23 (show KIF23 Antibodies) and KIF14 (show KIF14 Antibodies).
PRC1 is a docking partner for the Polo kinase (show PLK1 Antibodies) Plk1 (show PLK1 Antibodies) in anaphase cells. During metaphase this is inhibited by Cdk1 (show CDK1 Antibodies)-cyclin B phosphorylation at T470 and T481.
The presence of CBX4 or CBX8-GFP in the same focus had a minor impact on BMI1 and RING1 recovery kinetics.
Study finds that frictional forces increase nonlinearly with microtubule-associated proteins (MAP) velocity across microtubules and depend on filament polarity, with NuMA's friction being lower when moving toward minus ends, EB1 (show MAPRE2 Antibodies)'s lower toward plus ends, and PRC1's exhibiting no directional preference.
Studies reveal how interactions between the conserved nonmotor MAP, PRC1, and the motor protein, kinesin-4, generate filament length-dependent tags at microtubule plus ends. PRC1 tags ends of microtubules in dividing cells and the size of these tags increases linearly with filament length.
Different PRC1 paralog family members have nonredundant and locus-specific gene regulatory activities that are essential for human hematopoiesis.
findings suggest that PRC1 is regulated by Plk1 (show PLK1 Antibodies), rather than Cdk1 (show CDK1 Antibodies) as previously proposed, because its activity must be spatiotemporally regulated both preanaphase and postanaphase, and Cdk1 (show CDK1 Antibodies) activity is too binary for this purpose
Two distinct mechanisms are involved in CBX2 (show CBX2 Antibodies)-mediated gene silencing. The short CBX2 (show CBX2 Antibodies)-2 isoform would repress the transcription in a PRC1-independent fashion, whereas gene repression by the long CBX2 (show CBX2 Antibodies)-1 isoform is mediated by the PRC1 protein complex.
Cells depleted of PRC1 failed to form a polarized microtubule array or ectopic furrows following mitotic exit, and recruitment of Aurora B kinase (show AURKB Antibodies), male germ cell Rac GTPase-activating protein (show ARHGAP32 Antibodies), and RhoA (show RHOA Antibodies) to the cortex was impaired.
our findings show that PRC1 mediates gene repression by combining multiple and different effector mechanisms, of which H2A ubiquitination is a major contributor
This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants.
protein regulator of cytokinesis 1
, anaphase spindle elongation 1 homolog
, protein regulating cytokinesis 1