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putative protein tyrosine phosphatase based on sequence information, may be involved in signal transduction and\\/or protein amino acid dephosphorylation [RGD, Feb 2006].. Additionally we are shipping and many more products for this protein.
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Human Polyclonal PTPN23 Primary Antibody for WB - ABIN525501
Kim, Lee, Heynen-Genel, Suyama, Ono, Lee, Ideker, Aza-Blanc, Gleeson: Functional genomic screen for modulators of ciliogenesis and cilium length. in Nature 2010
HD-PTP acts as an alternative to ESCRT-II (show VPS28 Antibodies) and VPS20/CHMP6 (show CHMP6 Antibodies) as a link between the ESCRT-I (show VPS28 Antibodies) and those ESCRT-III protein(s) necessary for ILV formation.
Data indicate a regulatory function of non-receptor-type tyrosine phosphatase PTPN23 in maintaining a highly phosphorylated state of survival motor neuron (show SMN1 Antibodies) complex protein SMN (show STMN1 Antibodies).
PTPN23 is a tumor suppressor and that repression of PTPN23 expression by miR (show MLXIP Antibodies)-142-3p plays an important role in the pathogenesis of testicular germ cell tumors.
The ESCRT accessory protein HD-PTP/PTPN23 associates with epidermal growth factor receptor (EGFR (show EGFR Antibodies)) and combines with the deubiquitinating enzyme UBPY/USP8 (show USP8 Antibodies) to transfer EGFR (show EGFR Antibodies) from ESCRT-0 to ESCRT-III and drive EGFR (show EGFR Antibodies) sorting to intralumenal vesicles.
our findings suggest an evolutionarily conserved function of HDPTP-Rab4 (show RAB4A Antibodies) in the regulation of endocytic trafficking, cell adhesion and migration
HD-PTP degradation by calpains might result in the acquisition of a more aggressive phenotype in neoplastic cells.
loss of PTPN23 may increase the activity of SRC (show SRC Antibodies) and the phosphorylation status of the E-cadherin (show CDH1 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling complex to promote tumor growth and invasive behavior in breast cancer
Histidine domain-protein tyrosine phosphatase (show ACP1 Antibodies) interacts with Grb2 (show GRB2 Antibodies) and GrpL (show GRAP2 Antibodies)
These results suggest that HD-PTP amounts might be regulated both at the transcriptional and post-transcriptional levels.
data suggest that HD-PTP might participate in modulating endothelial response to angiogenic factors and play a role in regulating the complex events leading to the formation of new vessels
HD-PTP affects the intracellular sorting of activated PDGFRbeta and the migration, proliferation and tumorigenicity of cells stimulated by PDGF (show PDGFA Antibodies).
homozygous gene deletion is lethal around embryonic day 9.5, suggesting that Ptpn23 is an essential requirement for early stages of embryonic development
putative protein tyrosine phosphatase based on sequence information, may be involved in signal transduction and/or protein amino acid dephosphorylation
His-domain protein tyrosine phosphatase
, his domain-containing protein tyrosine phosphatase
, protein tyrosine phosphatase TD14
, tyrosine-protein phosphatase non-receptor type 23