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Protein Tyrosine Phosphatase, Receptor Type, N Proteins (PTPRN)

The protein encoded by PTPRN is a member of the protein tyrosine phosphatase (PTP) family. Additionally we are shipping PTPRN Antibodies (66) and PTPRN Kits (33) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PTPRN 5798 Q16849
PTPRN 19275  
Rat PTPRN PTPRN 116660 Q63259
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Top PTPRN Proteins at antibodies-online.com

Showing 8 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 Days
$522.50
Details
HOST_Escherichia coli (E. coli) Synthetic MAT tag   100 μg Log in to see 6 to 7 Days
$444.68
Details

PTPRN Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN) Interaction Partners

Human Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN) interaction partners

  1. Identification of amino acids contributing to distinct epitopes on IA-2, with both HLA-DR and HLA-DQ alleles influencing epitope specificity.

  2. RESP18HD is required for efficient sorting of ICA512 to secretory granules: RESP18HD is a key determinant for ICA512 granule targeting.

  3. The binding of CREB (show CREB1 Proteins) to the promoter region, -216 to +115, enhanced IA-2 transcription by more than fivefold.

  4. Kaplan-Meier survival curves estimated a worst pancreas graft survival for patients with positive IA-2 antibodies versus those patients with negative auto-antibodies and GAD65 (show GAD2 Proteins)+ auto-antibodies after simultaneous pancreas kidney transplantation.

  5. Humoral responses to islet antigen-2 and zinc transporter 8 are attenuated in patients carrying HLA-A*24 alleles at the onset of type 1 diabetes.

  6. Letter: report lack of anti-IA2 autoantibodies in primary antiphospholipid syndrome.

  7. analysis of protein-protein interactions in crystals of the human receptor-type protein tyrosine phosphatase (show ACP1 Proteins) ICA512 ectodomain

  8. In families with type 1 diabetes, there was a female predominance and more family history of associated autoimmune diseases (AAIDs) in the group with AAIDs, and less frequent anti-IA-2 antibodies

  9. Longer survival was associated with hypomethylation at specific CpG sites (e.g. GREB1, TGIF (show IL10 Proteins) and TOB1) and hypermethylation in other genes (e.g. TMCO5, PTPRN and GUCY2C (show GUCY2C Proteins)).

  10. Studies indicate that T1DM can be detected by determining four autoantibodies, namely those antibodies against insulin (show INS Proteins), glutamic acid decarboxylase 65 (show GAD2 Proteins), insulinoma (show RPS15 Proteins) antigen (IA)-2 (ICA512) and the zinc transporter ZnT8 (show SLC30A8 Proteins).

Mouse (Murine) Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN) interaction partners

  1. Ptprn is an activity dependent gene in mouse olfactory sensory neurons. [Ptprn]

  2. Data show that miRNAs are involved in regulating the expression of the major type 1 diabetes (T1D) autoantigens IA-2, IA-2beta (show PTPRN2 Proteins), and GAD65 (show GAD2 Proteins) enzyme.

  3. Experiments showed that the knock-out of IA-2, but not IA-2beta (show PTPRN2 Proteins), resulted in marked impairment of active avoidance learning; one copy of the gene was sufficient to maintain active avoidance learning

  4. Data show that the insulinoma associated protein-2 (show INSM2 Proteins) distribution in peripheral neurons appeared more intensely in neurites rather than in the cell bodies.

  5. IA-2-/- mice had higher sensitivity to STZ, suggesting a role of IA-2 not only in the secretion but also in the production of insulin (show INS Proteins).

  6. IA-2 is involved in glucose-stimulated insulin (show INS Proteins) secretion

  7. experiments show that the dense core vesicle proteins IA-2 and IA-2beta (show PTPRN2 Proteins), alone or in combination, are involved in insulin (show INS Proteins) secretion, but neither alone nor in combination are they required for the development of diabetes in NOD mice

  8. IA-2beta (show PTPRN2 Proteins), but not IA-2, is induced by ghrelin (show GHRL Proteins) and inhibits glucose-stimulated insulin (show INS Proteins) secretion

  9. The cleaved cytosolic fragment of ICA512 enhances the transcription of secretory granule genes (including its own gene) by binding to tyrosine phosphorylated signal transducers and activators of transcription (STAT) 5 (show STAT5A Proteins) and preventing its dephosphorylation.

  10. IA-2 beta (show PTPRN2 Proteins) undergoes at least three distinct proteolytic cleavages.

PTPRN Protein Profile

Protein Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with PTPRN

  • protein tyrosine phosphatase, receptor type, N (PTPRN)
  • protein tyrosine phosphatase, receptor type, N (Ptprn)
  • Ia-2 protein
  • IA-2/PTP protein
  • IA2 protein
  • ICA512 protein
  • mIA-A protein
  • mKIAA4064 protein
  • R-PTP-N protein

Protein level used designations for PTPRN

ICA 512 , PTP IA-2 , islet cell antigen 2 , islet cell antigen 512 , islet cell autoantigen 3 , protein tyrosine phosphatase-like N , receptor-type tyrosine-protein phosphatase-like N , ICA512 , R-PTP-N , islet cell autoantigen 512 , protein tyrosine phosphatase, receptor-type, N , 105 kDa islet cell antigen , BEM-3 , ICA105 , PTPLP , brain-enriched membrane-associated protein tyrosine phosphatase , insulinoma antigen-2 , receptor type N protein tyrosine phosphatase

GENE ID SPECIES
5798 Homo sapiens
286810 Bos taurus
19275 Mus musculus
116660 Rattus norvegicus
100355368 Oryctolagus cuniculus
100733759 Cavia porcellus
100155609 Sus scrofa
478921 Canis lupus familiaris
101113312 Ovis aries
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