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The protein encoded by PPFIA1 is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Additionally we are shipping Protein Tyrosine Phosphatase F Interacting Protein 1 Proteins (3) and many more products for this protein.
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Based on these findings, we infer that high PPFIA1 expression might be an independent prognostic indicator of increased metastatic relapse risk in patients with estrogen receptor (show ESR1 Antibodies)+/N- breast cancer, but not in estrogen receptor (show ESR1 Antibodies)+/N+ or estrogen receptor (show ESR1 Antibodies)- patients.
These results indicate that liprin-alpha1 localizes to different adhesion and cytoskeletal structures to regulate vimentin (show VIM Antibodies) intermediate filament network, thereby altering the invasion and growth properties of the cancer cells.
The human tumor cell line MDA-MB-231 expresses liprin-alpha 1 and is able to promote the formation of metastasis in mice.
results suggested that PPFIA1 functioned with PP2A (show PPP2R4 Antibodies) to promote the dephosphorylation of Kif7 (show KIF7 Antibodies), triggering Kif7 (show KIF7 Antibodies) localization to the tips of primary cilia and promoting Gli (show GLI1 Antibodies) transcriptional activity.
Liprin-alpha1, ERC1a and LL5 (show PHLDB1 Antibodies) also define new highly polarized and dynamic cytoplasmic structures uniquely localized near the protruding cell edge
PPFIA1 was frequently co-amplified with the Cyclin D1 (show CCND1 Antibodies) gene in oral carcinomas and could present a biomarker as well as a novel target for specific gene therapy.
PPFIA1 as a potential functional candidate acute lung injury risk gene
The results of this study finding suggested that a model by which the self-assembly of SYD-2 (show MAPK8IP3 Antibodies)/Liprin-alpha proteins mediated by the coiled-coil LH1 domain is one of the key steps to the accumulation of presynaptic components at nascent synaptic junctions
These results suggest that an increased expression of Liprin-alpha1 in the brain may be associated with human Intractable epilepsy .
Data show that increased levels of liprin-alpha1 affected the localization of inactive, low-affinity integrins, while increasing the average size of beta1 integrin-positive focal adhesions.
results suggested that PPFIA1 functioned with PP2A (show PPP2R2B Antibodies) to promote the dephosphorylation of Kif7 (show KIF7 Antibodies), triggering Kif7 (show KIF7 Antibodies) localization to the tips of primary cilia and promoting Gli (show GLI1 Antibodies) transcriptional activity.
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described.
LAR-interacting protein 1
, PTPRF-interacting protein alpha-1
, protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1
, protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein, alpha 1