Protein Tyrosine Phosphatase G1 (PTPN12) ELISA Kits

The protein encoded by PTPN12 is a member of the protein tyrosine phosphatase (PTP) family. Additionally we are shipping PTPN12 Antibodies (47) and PTPN12 Proteins (9) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human PTPN12 PTPN12 5782 Q05209
Anti-Mouse PTPN12 PTPN12 19248 P35831
Anti-Rat PTPN12 PTPN12 117255  
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More ELISA Kits for PTPN12 Interaction Partners

Human Protein Tyrosine Phosphatase G1 (PTPN12) interaction partners

  1. MyoVa (show MYO5A ELISA Kits)-Ca(2 (show CA2 ELISA Kits)+) channel interactions are required for proper long-range axon growth in developing spinal cord in vivo.

  2. PTP-PEST regulates EphA3 (show EPHA3 ELISA Kits) activation both by affecting cytoskeletal remodelling and through its direct action as a PTP (show SLC25A3 ELISA Kits) controlling EphA3 (show EPHA3 ELISA Kits) phosphorylation.

  3. Study suggests that PTPN12 expression is a valuable prognostic biomarker for non-small cell lung cancer.

  4. PTPN12 expression decreases in human renal cell carcinoma

  5. The decrease expression of PTPN12 might be important in conferring a more aggressive behavior in NPC (show NPC1 ELISA Kits). Thus, PTPN12 expression may be used as a novel independent prognostic biomarker for patients with NPC (show NPC1 ELISA Kits).

  6. PTPN12 is potentially a methylation-silenced TSG (show TWSG1 ELISA Kits) for breast cancer that may play an important role in breast carcinogenesis and could potentially serve as an independent prognostic factor for invasive breast cancer patients.

  7. Decreased expression of PTPN12 correlates with tumor recurrence and poor survival of patients with hepatocellular carcinoma.

  8. these data suggest that PTP-PEST affects epithelial cell motility by controlling the distribution and phosphorylation of p120 (show HNRNPU ELISA Kits) and its availability to control Rho GTPase (show RACGAP1 ELISA Kits) activity.

  9. The involvement of PTPN12 in the antioxidant response of breast cancer cells suggests that PTPN12 may represent a novel therapeutic target for this disease

  10. Overexpression of PTPN12 inhibited proliferation and migration in OSCC cells.

Mouse (Murine) Protein Tyrosine Phosphatase G1 (PTPN12) interaction partners

  1. PTPN12-deficient, ErbB2 (show ERBB2 ELISA Kits)-dependent breast cancer cells were more resistant to anoikis and had augmented migratory and invasive properties.

  2. Integrin beta 8 and PTP-PEST form protein complexes at the leading edge of migrating cells and balance patterns of Rac1 and Cdc42 (show CDC42 ELISA Kits) signaling by controlling the subcellular localization and phosphorylation status of Rho GDP dissociation inhibitor 1 (show ARHGDIA ELISA Kits).

  3. Pyk2 (show PTK2B ELISA Kits) deregulation played a pivotal role in the migration defect caused by PTPN12 deficiency.

  4. Regulation of the Src kinase-associated phosphoprotein (show SKAP2 ELISA Kits) 55 homologue by the protein tyrosine phosphatase (show ACP1 ELISA Kits) PTP-PEST in the control of cell motility.

  5. macrophage fusion is critically dependent on PTP-PEST.

  6. Overexpression of PTP-PEST substantially inhibits lipopolysaccharide (LPS (show TLR4 ELISA Kits))-induced tyrosine phosphorylation of IkappaB kinase (show CHUK ELISA Kits) (IKKbeta (show IKBKB ELISA Kits)) at Tyr188/199 in RAW264.7 cells.

  7. PTP-PEST is a key regulator of integrin-mediated functions in endothelial cells.

  8. the dephosphorylation of Pyk2 (show PTK2B ELISA Kits) requires dynamin's GTPase (show RACGAP1 ELISA Kits) activity and is mediated by the tyrosine phosphatase PTP-PEST.

  9. PTP-PEST controls Pyk2 (show PTK2B ELISA Kits) activity and is a positive regulator of secondary T cell activation.

  10. the paxillin (show PXN ELISA Kits)-PTP-PEST interaction contributes to integrin signaling

PTPN12 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with PTPN12

  • protein tyrosine phosphatase, non-receptor type 12 (PTPN12) antibody
  • protein tyrosine phosphatase, non-receptor type 12 (Ptpn12) antibody
  • P19-PTP antibody
  • PTP-P19 antibody
  • PTP-PEST antibody
  • Ptpg1 antibody
  • RKPTP antibody

Protein level used designations for PTPN12

protein-tyrosine phosphatase G1 , tyrosine-protein phosphatase non-receptor type 12 , MPTP-PEST , protein-tyrosine phosphatase P19

5782 Homo sapiens
19248 Mus musculus
117255 Rattus norvegicus
531877 Bos taurus
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