Protein Tyrosine Phosphatase G1 Proteins (PTPN12)

The protein encoded by PTPN12 is a member of the protein tyrosine phosphatase (PTP) family. Additionally we are shipping PTPN12 Antibodies (47) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PTPN12 5782 Q05209
PTPN12 19248 P35831
Rat PTPN12 PTPN12 117255  
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Top PTPN12 Proteins at

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
HOST_Baculovirus infected Insect Cells Human GST tag,His tag 100 μg Log in to see 20 to 21 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 20 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HOST_Escherichia coli (E. coli) Human GST tag   5 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Log in to see 15 to 18 Days

PTPN12 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , , ,
Mouse (Murine)

More Proteins for Protein Tyrosine Phosphatase G1 (PTPN12) Interaction Partners

Human Protein Tyrosine Phosphatase G1 (PTPN12) interaction partners

  1. MyoVa (show MYO5A Proteins)-Ca(2 (show CA2 Proteins)+) channel interactions are required for proper long-range axon growth in developing spinal cord in vivo.

  2. PTP-PEST regulates EphA3 (show EPHA3 Proteins) activation both by affecting cytoskeletal remodelling and through its direct action as a PTP (show SLC25A3 Proteins) controlling EphA3 (show EPHA3 Proteins) phosphorylation.

  3. Study suggests that PTPN12 expression is a valuable prognostic biomarker for non-small cell lung cancer.

  4. PTPN12 expression decreases in human renal cell carcinoma (show MOK Proteins)

  5. The decrease expression of PTPN12 might be important in conferring a more aggressive behavior in NPC (show NPC1 Proteins). Thus, PTPN12 expression may be used as a novel independent prognostic biomarker for patients with NPC (show NPC1 Proteins).

  6. PTPN12 is potentially a methylation-silenced TSG (show TWSG1 Proteins) for breast cancer that may play an important role in breast carcinogenesis and could potentially serve as an independent prognostic factor for invasive breast cancer patients.

  7. Decreased expression of PTPN12 correlates with tumor recurrence and poor survival of patients with hepatocellular carcinoma.

  8. these data suggest that PTP-PEST affects epithelial cell motility by controlling the distribution and phosphorylation of p120 (show HNRNPU Proteins) and its availability to control Rho GTPase (show RACGAP1 Proteins) activity.

  9. The involvement of PTPN12 in the antioxidant response of breast cancer cells suggests that PTPN12 may represent a novel therapeutic target for this disease

  10. Overexpression of PTPN12 inhibited proliferation and migration in OSCC cells.

Mouse (Murine) Protein Tyrosine Phosphatase G1 (PTPN12) interaction partners

  1. PTPN12-deficient, ErbB2 (show ERBB2 Proteins)-dependent breast cancer cells were more resistant to anoikis and had augmented migratory and invasive properties.

  2. Integrin beta 8 and PTP-PEST form protein complexes at the leading edge of migrating cells and balance patterns of Rac1 and Cdc42 (show CDC42 Proteins) signaling by controlling the subcellular localization and phosphorylation status of Rho GDP dissociation inhibitor 1 (show ARHGDIA Proteins).

  3. Pyk2 (show PTK2B Proteins) deregulation played a pivotal role in the migration defect caused by PTPN12 deficiency.

  4. Regulation of the Src kinase-associated phosphoprotein (show SKAP2 Proteins) 55 homologue by the protein tyrosine phosphatase (show ACP1 Proteins) PTP-PEST in the control of cell motility.

  5. macrophage fusion is critically dependent on PTP-PEST.

  6. Overexpression of PTP-PEST substantially inhibits lipopolysaccharide (LPS (show TLR4 Proteins))-induced tyrosine phosphorylation of IkappaB kinase (show CHUK Proteins) (IKKbeta (show IKBKB Proteins)) at Tyr188/199 in RAW264.7 cells.

  7. PTP-PEST is a key regulator of integrin-mediated functions in endothelial cells.

  8. the dephosphorylation of Pyk2 (show PTK2B Proteins) requires dynamin's GTPase (show RACGAP1 Proteins) activity and is mediated by the tyrosine phosphatase PTP-PEST.

  9. PTP-PEST controls Pyk2 (show PTK2B Proteins) activity and is a positive regulator of secondary T cell activation.

  10. the paxillin (show PXN Proteins)-PTP-PEST interaction contributes to integrin signaling

PTPN12 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with PTPN12

  • protein tyrosine phosphatase, non-receptor type 12 (PTPN12)
  • protein tyrosine phosphatase, non-receptor type 12 (Ptpn12)
  • P19-PTP protein
  • PTP-P19 protein
  • PTP-PEST protein
  • Ptpg1 protein
  • RKPTP protein

Protein level used designations for PTPN12

protein-tyrosine phosphatase G1 , tyrosine-protein phosphatase non-receptor type 12 , MPTP-PEST , protein-tyrosine phosphatase P19

5782 Homo sapiens
19248 Mus musculus
117255 Rattus norvegicus
531877 Bos taurus
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