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a putative protein-tyrosine-phosphatase that is found enriched within the striatum.
Showing 4 out of 4 products:
STEP61 regulates BDNF (show BDNF Antibodies) expression, with implications for cognitive functioning in CNS disorders.
The study provides further insight into the mechanisms of regulation of STEP61 and also offers a molecular basis for the Zn(2+)-induced sustained activation of ERK2 (show MAPK1 Antibodies).
These results indicate that STEP61 is a novel substrate of parkin (show PARK2 Antibodies), although further studies are necessary to determine whether elevated STEP61 levels directly contribute to the pathophysiology of PD.
Abeta (show APP Antibodies) regulating STEP61 activity is mediated by Abeta (show APP Antibodies) binding to alpha7 nAChRs
Increased STEP and calpain activation contribute to altered NMDAR (show GRIN1 Antibodies) localization in an Huntington's disease mouse model.
genetically reducing STEP significantly diminishes seizures and restores select social and nonsocial anxiety-related behaviors in Fmr1 (show FMR1 Antibodies)(KO) mice
the first study to identify Pyk2 (show PTK2B Antibodies) as a substrate for STEP.
Increased STEP61 plays a role in amyloid Abeta (show APP Antibodies)-mediated internalization of the (AMPAR) subunits GluA1 (show GRIA1 Antibodies)/GluA2 (show GRIA2 Antibodies) (formerly GluR1 (show GRIA1 Antibodies)/GluR2 (show GRIA2 Antibodies)).
STEP pathway is severely downregulated in the presence of mutant huntingtin (show HTT Antibodies) and may participate in compensatory mechanisms activated by striatal neurons that lead to resistance to excitotoxicity.
Electrical stimulation of the hippocampal-entorhinal cortex pathway in STEP knockout mice resulted in less activation of the dentate gyrus granule cell layer (GCL), but greater activation of the hilus in STEP knockouts, compared with heterozygous slices.
May regulates the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors (By similarity).
neural-specific protein-tyrosine phosphatase
, striatum-enriched protein-tyrosine phosphatase
, tyrosine-protein phosphatase non-receptor type 5
, protein-tyrosine phosphatase striatum-enriched
, protein-tyrosine-phosphatase non-receptor 5