Protein Tyrosine Phosphatase Type IVA, Member 3 Proteins (PTP4A3)

The protein encoded by PTP4A3 belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). Additionally we are shipping PTP4A3 Antibodies (75) and PTP4A3 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PTP4A3 19245 Q9D658
PTP4A3 11156 O75365
Rat PTP4A3 PTP4A3 362930  
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Top PTP4A3 Proteins at antibodies-online.com

Showing 9 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$242.00
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 20 Days
$785.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 2 to 3 Days
$190.93
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 2 to 3 Days
$273.57
Details
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 15 to 18 Days
$672.00
Details
Human Un-conjugated   10 μg Log in to see 6 Days
$168.54
Details

PTP4A3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
, ,

More Proteins for Protein Tyrosine Phosphatase Type IVA, Member 3 (PTP4A3) Interaction Partners

Mouse (Murine) Protein Tyrosine Phosphatase Type IVA, Member 3 (PTP4A3) interaction partners

  1. our results suggest that the Prl3b1-cre mice line provides a unique resource to understand testicular germ-cell development

  2. Results demonstrate that Ptp4a3 contributes to the malignant phenotype of tumor-initiating cells.

  3. PRL-3 protein was significantly reduced in mouse STAT3 (show STAT3 Proteins)-knockout liver cells compared with STAT3 (show STAT3 Proteins)-wild type counterparts, and ectopic expression of STAT3 (show STAT3 Proteins) in these cells led to a pronounced increase in PRL-3 protein.

  4. Data indicate that Mycobacterium tuberculosis T cell stimulatory epitope (MT) is a potentially effective molecular adjuvant in preparation of monoclonal antibody (mAb) specific for phosphatase of regenerating liver-3 (PRL-3).

  5. These findings strongly support a role for PTP4A3 as an important contributor to endothelial cell function and as a multimodal target for cancer therapy and mitigating VEGF-regulated angiogenesis.

  6. the first definitive evidence implicating Ptp4a3 in colon tumorigenesis

  7. role of PTP4A3 in acute myeloid leukemia (show BCL11A Proteins)

  8. PTP4A3 was identified as a novel negative regulator of LPS (show TLR4 Proteins)-induced LITAF/TNF-alpha production.

  9. PRL-3 was highly expressed in metastatic melanoma B16-BL6 cells but not in its lowly metastatic parental cell line, B16 cells

  10. PRL-3-expressing cells rapidly induce metastatic tumor formation in lung

Human Protein Tyrosine Phosphatase Type IVA, Member 3 (PTP4A3) interaction partners

  1. our result indicated that PRL-3 promotes protein phosphorylation by acting as an 'activator kinase' and consequently regulates cytokine secretion.

  2. The disruption of epithelial architecture by PRL-3 revealed here is a newly recognized mechanism for PRL-3-promoted cancer progression.

  3. This study suggests PRL-3 and SFKs are key mediators of the IL6 (show IL6 Proteins)-driven signaling events.

  4. Regulation of PTP4A3 expression is altered in specific subgroups of acute leukemias and this is likely brought about by expression of the aberrant ETV6 (show ETV6 Proteins)-RUNX1 (show RUNX1 Proteins) and BCR (show BCR Proteins)-ABL1 (show ABL1 Proteins) fusion genes.

  5. PRL-3 engages the focal adhesion pathway in trip0le-negative breast cancer cells as a key mechanism for promoting TNBC cell migration and invasion.

  6. PTP4A3 regulated glioblastoma multiforme via miR (show MLXIP Proteins)-137-mediated Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signaling pathway.

  7. Studies suggest that transcriptional, translational, or posttranslational regulation might be involved in the aberrant expression of phosphatase of regenerating liver (PRL)-3.

  8. we observed that PRL-3 regulated the clustering of integrin beta1 in FAs (show FAS Proteins) on collagen I but not on fibronectin (show FN1 Proteins). This work identifies PRL-3 as a new regulator of cell adhesion structures to the extracellular matrix, and further supports PRL-3 as a key actor of metastasis in uveal melanoma, of which molecular mechanisms are still poorly understood

  9. PTP4A3 may play a role in bladder cancer oncogenesis and is a predictive marker of metastasis. PTP4A3 overexpression represents an independent prognosticator for BC, suggesting its potential theranostic value.

  10. our results provide a bridge between PRL-3 and PTEN; PRL-3 decreased the expression of PTEN as well as increased the level of PTEN phosphorylation and inactivated it, consequently activating the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling pathway, and upregulating MMP-2 (show MMP2 Proteins)/MMP (show MMP2 Proteins)-9 (show MMP9 Proteins) expression to promote gastric cancer cell peritoneal metastasis.

Zebrafish Protein Tyrosine Phosphatase Type IVA, Member 3 (PTP4A3) interaction partners

  1. Results uncovered that aberrant overexpression of PRL-3 could initiate chordoma in early development.

Xenopus laevis Protein Tyrosine Phosphatase Type IVA, Member 3 (PTP4A3) interaction partners

  1. Data show that protein-tyrosine phosphatase (show ACP1 Proteins) PRP4A3 (prl3) and van gogh like1 (vangl1 (show Vangl1 Proteins)) are Necessary Components in prohibitin1 (phb1 (show PHB Proteins)) dependent neural crest specification.

  2. PTP4A3 is required for cephalic neural crest migration in vivo during embryonic development.

PTP4A3 Protein Profile

Protein Summary

The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist.

Gene names and symbols associated with PTP4A3

  • protein tyrosine phosphatase type IVA, member 3 (PTP4A3)
  • protein tyrosine phosphatase type IVA, member 3 (ptp4a3)
  • protein tyrosine phosphatase type IVA, member 3 (LOC100342107)
  • protein tyrosine phosphatase 4a3 (Ptp4a3)
  • protein tyrosine phosphatase type IVA, member 2 (PTP4A2)
  • protein tyrosine phosphatase type IVA, member 3 (Ptp4a3)
  • AV088979 protein
  • pPtp4a3 protein
  • prl-3 protein
  • PRL-R protein
  • prl3 protein
  • PTP4A3 protein
  • ptpcaax3 protein
  • wu:fc54b05 protein
  • wu:fv52d11 protein
  • zgc:77109 protein

Protein level used designations for PTP4A3

protein tyrosine phosphatase type IVA, member 3 , protein tyrosine phosphatase type IVA 3 , protein-tyrosine phosphatase 4a3 , protein-tyrosine phosphatase of regenerating liver 3 , potentially prenylated protein tyrosine phosphatase , protein tyrosine phosphatase 4a3 , PRL-3 , fc54b05 , fv52d11 , xPRL-3

GENE ID SPECIES
737820 Pan troglodytes
100216017 Xenopus (Silurana) tropicalis
100342107 Oryctolagus cuniculus
19245 Mus musculus
614435 Bos taurus
11156 Homo sapiens
362930 Rattus norvegicus
406460 Danio rerio
432351 Xenopus laevis
768713 Gallus gallus
606961 Canis lupus familiaris
100137722 Bos taurus
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