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PROZ encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. Additionally we are shipping PROZ Antibodies (28) and PROZ Kits (11) and many more products for this protein.
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Letter: protein Z is not a typical acute phase reactant.
PZ and ZPI (show SERPINA10 Proteins) deficiency would be associated with a modest thrombotic risk with ZPI (show SERPINA10 Proteins) deficiency producing a more severe phenotype.
Results show the energetic basis of the Z-dependent protease inhibitor (ZPI (show SERPINA10 Proteins))-protein Z (PZ) interaction and suggest an important role for ZPI (show SERPINA10 Proteins) Lys (show LYZ Proteins)-239 in PZ catalytic action.
The unbalance between PZ and ZPI (show SERPINA10 Proteins) in plasma samples from patients with Colorectal Cancer or Pancreatic Cancer is not only related to an inflammatory state but could also results from an ectopic synthesis of these proteins by the cancer cells.
Protein Z EGF2 subdomain constitutes an interactive-site for ZPI (show SERPINA10 Proteins) protein.
Protein Z/protein Z-dependent protease inhibitor (show SERPINA10 Proteins) and Fxa (show F10 Proteins) expression in human gastric cancer cells indicate that these proteins may play a role in anticoagulant events at the tumor tissue.
active mutations of PZ in the serine protease (show F2 Proteins) structural domain were found in women with fetal loss
Data suggest role for complex of PZ with ZPI (PZ-dependent protease inhibitor (show SERPINA10 Proteins)) in pregnancy maintenance; this is highlighted by progressive elevation in PZ levels in first trimester of gestation which then steadily decline toward delivery. [REVIEW]
the PZ/ZPI (show SERPINA10 Proteins) complex may play some modulating role in hemophilia A
74 patients a protein Z deficiency has been found.
PZ can be a cofactor associated with an increased bleeding tendency in patients with AML (show RUNX1 Proteins).
expression of PROZ in PLC/PRF/5 cells increased cell viability and clonogenicity compared to mock-transfected cells.
This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants.
vitamin K-dependent protein Z
, protein Z, vitamin K-dependent plasma glycoprotein
, hypothetical LOC558106
, protein Z, vitamin K-dependent plasma protein