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Protein tyrosine Phosphatase, Non-Receptor Type 13 (APO-1/CD95 (Fas)-Associated Phosphatase) Proteins (PTPN13)

The protein encoded by PTPN13 is a member of the protein tyrosine phosphatase (PTP) family. Additionally we are shipping PTPN13 Antibodies (50) and PTPN13 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse PTPN13 PTPN13 19249 Q64512
PTPN13 5783 Q12923
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Top PTPN13 Proteins at

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human GST tag   5 μg Log in to see 10 to 12 Days

PTPN13 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

More Proteins for Protein tyrosine Phosphatase, Non-Receptor Type 13 (APO-1/CD95 (Fas)-Associated Phosphatase) (PTPN13) Interaction Partners

Mouse (Murine) Protein tyrosine Phosphatase, Non-Receptor Type 13 (APO-1/CD95 (Fas)-Associated Phosphatase) (PTPN13) interaction partners

  1. The data show that the levels of PTPN13 and beta-catenin (show CTNNB1 Proteins) must be strictly regulated by extracellular signaling to regulate hematopoietic stem cells attachment to the bone marrow niche and the balance between proliferation and quiescence.

  2. The study presents a detailed kinetics analysis of the interaction between PTP-BL PDZ2 domain and a peptide mimicking the PDZ binding motif of APC (show APC Proteins).

  3. SDCCAG3 (show SDCCAG3 Proteins) forms a complex with PTPN13. Interaction of SDCCAG3 (show SDCCAG3 Proteins) with PTPN13 is mediated via the FERM domain of PTPN13 and via the N-terminus of SDCCAG3 (show SDCCAG3 Proteins).

  4. Data indicate that Bcr-abl (show ABL1 Proteins) increases PTPN13 promoter activity in an Icsbp (show IRF8 Proteins)-dependent manner.

  5. Since PTPL1 catalytic activity is important for cell transformation, VCP (show vcp Proteins) regulation by PTPL1 might be important for tumorigenesis.

  6. These findings demonstrate a key role for PTP-BL in 3T3-L1 and mouse embryo fibroblasts-derived adipocyte differentiation that is independent of its enzymatic activity.

  7. Structure, dynamics and binding characteristics of the second PDZ domain of PTP-BL

  8. With delayed kinetics, ephrinB ligands recruit the cytoplasmic PDZ domain containing protein (show USH1C Proteins) tyrosine phosphatase PTP-BL and are dephosphorylated.

  9. FAP-1 has a role in binding to, and consequently inhibition of, Fas (show FAS Proteins) export to the cell surface

  10. examination of potential role of PTP-BL in the dynamics of the cortical actin cytoskeleton

Human Protein tyrosine Phosphatase, Non-Receptor Type 13 (APO-1/CD95 (Fas)-Associated Phosphatase) (PTPN13) interaction partners

  1. Mutation in PTPN13 gene is associated with gastric cancer peritoneal carcinomatosis.

  2. This work studied heat diffusion in the well-known PDZ-2 protein, and confirmed that this protein has two cognate allosteric pathways and that heat flows preferentially through these.

  3. Necl-4 serves as a novel regulator for contact inhibition of cell movement and proliferation cooperatively with the VEGF receptor and PTPN13

  4. A PDZ-mediated interaction of PTPN13 and PTEN is described with possible relevance for tumor suppression.

  5. The effect of the viscogens sucrose, and glycerol on the kinetic response of a photoperturbed PTPN13 is investigated.

  6. A comprehensive molecular dynamics simulation study of the PDZ2 domain of human tyrosine phosphatase 1E in the ligand-bound and -free state, as well as the photoswitchable protein in the cis (show CISH Proteins) and trans states of the photoswitch

  7. Thus, our results suggest a previously unknown Stat3-PTPN13 molecular network controlling squamous cell lung carcinoma development

  8. Association of rs7014346 in POU5F1P1, rs989902 in PTPN13, and rs7003146 in TCF7L2 with variations in the risk of breast cancer in a Chinese Han population.

  9. HCV induced increased expression of miR200c can down modulate the expression of FAP1, a critical regulator of Src (show SRC Proteins) and MAP kinase (show MAPK1 Proteins) pathway that play an important role in the production of fibrogenic growth factors and development of fibrosis.

  10. selective autophagic degradation of the phosphatase Fap-1 promotes Fas (show FAS Proteins) apoptosis.

PTPN13 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.

Gene names and symbols associated with PTPN13

  • protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) (PTPN13)
  • similar to protein tyrosine phosphatase type 1 (PTPN13)
  • protein tyrosine phosphatase, non-receptor type 13 (ptpn13)
  • protein tyrosine phosphatase, non-receptor type 13 (PTPN13)
  • protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) (ptpn13)
  • protein tyrosine phosphatase, non-receptor type 13 (Ptpn13)
  • AI324989 protein
  • FAP-1 protein
  • hPTP1E protein
  • PNP1 protein
  • PTP-BAS protein
  • PTP-BL protein
  • PTP1E protein
  • PTPL1 protein
  • PTPLE protein
  • ptpn13 protein
  • Ptpri protein
  • RIP protein

Protein level used designations for PTPN13

protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) , protein tyrosine phosphatase, non-receptor type 13 , protein-tyrosine phosphatase BAS , tyrosine-protein phosphatase non-receptor type 13-like , PTP36 , protein tyrosine phosphatase DPZPTP , protein tyrosine phosphatase PTP-BL , protein-tyrosine phosphatase RIP , tyrosine phosphatase , tyrosine-protein phosphatase non-receptor type 13 , fas-associated protein-tyrosine phosphatase 1 , hPTPE1 , protein-tyrosine phosphatase 1E , protein-tyrosine phosphatase PTPL1

422591 Gallus gallus
461359 Pan troglodytes
569591 Danio rerio
100144609 Felis catus
100455138 Pongo abelii
100477379 Ailuropoda melanoleuca
100521910 Sus scrofa
100540743 Meleagris gallopavo
100566747 Anolis carolinensis
100603082 Nomascus leucogenys
19249 Mus musculus
5783 Homo sapiens
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