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The protein encoded by PTPN14 is a member of the protein tyrosine phosphatase (PTP) family. Additionally we are shipping PTPN14 Antibodies (34) and and many more products for this protein.
PTPN14, a Pez mammalian homolog, is degraded by overexpressed Su(dx) or Su(dx) homologue WWP1 in mammalian cells.
PTPN14 and PTEN were identified as direct and functional targets of miR (show MLXIP ELISA Kits)-21.
Findings indicate a pathway involving protein-tyrosine phosphatase (show ACP1 ELISA Kits) D2 PTPD2 (PTPN14) and the lipid second messenger phosphatidic acid that promotes ERBB2 (show ERBB2 ELISA Kits) receptor function.
results indicate a potential regulatory role of PTPN14 in the Hippo pathway and demonstrate another layer of regulation in the YAP (show YAP1 ELISA Kits) oncogenic function
Data demonstrate that PTPN14 downregulation can phenocopy YAP (show YAP1 ELISA Kits) activation in mammary epithelial cells and synergize with YAP (show YAP1 ELISA Kits) to induce oncogenic transformation.
Data show that p130 (show RBL2 ELISA Kits) Crk-associated substrate (show BCAR1 ELISA Kits) is a direct substrate of PTPN14 and that PTPN14 specifically regulates p130Cas (show BCAR1 ELISA Kits) phosphorylation at tyrosine residue 128 in colorectal cancer cells.
YAP (show YAP1 ELISA Kits) is a direct substrate of PTPN14. Results indicate a potential regulatory role of PTPN14 on YAP (show YAP1 ELISA Kits) and demonstrate a novel mechanism in YAP (show YAP1 ELISA Kits) regulation.
YAP (show YAP1 ELISA Kits) forms a protein complex with PTPN14 through the WW domains of YAP (show YAP1 ELISA Kits) and the PPXY motifs of PTPN14.
that PTPN14 acts to suppress cell proliferation by promoting cell density-dependent cytoplasmic translocation of YAP1 (show YAP1 ELISA Kits)
PTPN14 has a role in angiogenesis and/or arteriovenous fate, acting via EphrinB2 (show EFNB2 ELISA Kits) and ACVRL1/activin receptor-like kinase 1 (show ACVRL1 ELISA Kits)
The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia.
cytoskeletal-associated protein tyrosine phosphatase
, protein-tyrosine phosphatase pez
, tyrosine-protein phosphatase non-receptor type 14
, protein-tyrosine phosphatase PTP36