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The protein encoded by PTPRA is a member of the protein tyrosine phosphatase (PTP) family. Additionally we are shipping PTPRA Proteins (11) and PTPRA Kits (3) and many more products for this protein.
Showing 10 out of 93 products:
Human Polyclonal PTPRA Primary Antibody for EIA, WB - ABIN360736
Kaplan, Morse, Huebner, Croce, Howk, Ravera, Ricca, Jaye, Schlessinger: Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. in Proceedings of the National Academy of Sciences of the United States of America 1990
Show all 5 references for ABIN360736
Human Monoclonal PTPRA Primary Antibody for IF, IP - ABIN967914
Sap, DEustachio, Givol, Schlessinger: Cloning and expression of a widely expressed receptor tyrosine phosphatase. in Proceedings of the National Academy of Sciences of the United States of America 1990
Show all 3 references for ABIN967914
Chicken Polyclonal PTPRA Primary Antibody for WB - ABIN2782196
Zheng, Resnick, Shalloway: Apoptosis of estrogen-receptor negative breast cancer and colon cancer cell lines by PTP alpha and src RNAi. in International journal of cancer. Journal international du cancer 2008
A receptor type-protein tyrosine phosphatase alpha-Src (show SRC Antibodies) family kinase-Rap1 (show RABGEF1 Antibodies) pathway was identified as responsible for recruiting myosin IIB (show MYH10 Antibodies) to the zonula adherens in epithelial cells and supporting contractile tension.
no evidence was seen for the association of rare, missense mutations in the PTPRA gene with schizophrenia or autism spectrum disorders
Data indicate that scaffold protein (show HOMER1 Antibodies) RACK1 (show GNB2L1 Antibodies) plays a role in IGF-1 (show IGF1 Antibodies)-mediated protein-tyrosine phosphatase alpha (PTPalpha) tyrosine phosphorylation in MCF-7 Cells.
recruited to epithelial adherens junctions for cadherin-dependent cell adhesion and tissue architecture formation
Results suggest that inhibition of PTPalpha can have a beneficial effect on HER2 (show ERBB2 Antibodies)-positive breast cancers, but that inhibition of additional targets is needed to block breast tumorigenesis.
new role for PTPalpha in the regulation of motility of mammary epithelial cells in response to ErbB2 (show ERBB2 Antibodies) activation.
results suggest that PTPalpha links activation of epidermal growth factor receptor (EGFR (show EGFR Antibodies)) signaling with Src (show SRC Antibodies) activation and may provide a novel therapeutic target for treatment of breast cancer.
A single-nucleotide polymorphism (rs6138953) on the PTPRA gene in the 20p13 region was found to be associated with elevated fasting glucose level.
The extracellular proteolytic processing is a novel mechanism for PTPalpha regulation.
our results suggest that plasma PTPalpha and fibronectin (show FN1 Antibodies) may be associated with opisthorchiasis.
RPTPalpha mediates proinflammatory and proinvasive signaling in rheumatoid arthritis fibroblast-like synoviocytes (FLS), correlating with the promotion of disease in an FLS-dependent model of rheumatoid arthritis.
Ptpra coordinates the regulation of the Fyn (show FYN Antibodies) signaling pathway in corpus striatum.
PTPs (show PTS Antibodies) alpha and epsilon play distinct roles in osteoclasts.
PTP (show SLC25A3 Antibodies)-alpha promotes profibrotic signaling pathways in fibroblasts through control of cellular responsiveness to TGF-beta (show TGFB1 Antibodies).
The focal adhesion targeting domain of FAK (show PTK2 Antibodies) interacts with protein-tyrosine phosphatase-alpha to restrict IL1 (show IL1A Antibodies)-induced Ca2 (show CA2 Antibodies)+ release, ERK (show EPHB2 Antibodies) activation, and MMP-9 (show MMP9 Antibodies) expression.
PTPalpha may be involved in the formation of axoglial junctions and ensheathment in small axons during myelination of the spinal cord.
Findings indicate Grb2 (show GRB2 Antibodies) as a new FAK (show PTK2 Antibodies) activator and in coordinating PTPalpha tyrosine phosphorylation to enable downstream integrin signaling and migration.
Inflammation-induced connective tissue degradation involving fibroblasts requires functionally active PTPalpha.
study described a molecular complex of PTPalpha-BCAR3 (show BCAR3 Antibodies)-Cas (show CTNND1 Antibodies)-Src (show SRC Antibodies); this complex forms in response to PTPalpha Tyr789 phosphorylation and mediates Cas (show CTNND1 Antibodies) localization to focal adhesions and Cas (show CTNND1 Antibodies) downstream signaling to promote cell migration
ptpra protein, zebrafish, signaling is essential for convergence and extension cell movements during gastrulation.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported.
protein tyrosine phosphatase, receptor type, A
, receptor-type tyrosine-protein phosphatase alpha-like
, Leukocyte common antigen-related peptide (protein tyrosine phosphate)
, PTPLCA-related phosphatase
, protein tyrosine phosphatase, receptor type, alpha polypeptide
, protein-tyrosine phosphatase alpha
, receptor-type tyrosine-protein phosphatase alpha
, tyrosine phosphatase alpha
, LCA-related phosphatase
, protein tyrosine phosphatase alpha
, protein tyrosine phosphatase receptor type alpha
, protein-tyrosine-phosphatase alpha