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Protein tyrosine Phosphatase, Receptor Type, A Proteins (PTPRA)

The protein encoded by PTPRA is a member of the protein tyrosine phosphatase (PTP) family. Additionally we are shipping PTPRA Antibodies (93) and PTPRA Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PTPRA 5786 P18433
PTPRA 19262 P18052
PTPRA 25167  
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Top PTPRA Proteins at antibodies-online.com

Showing 8 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Baculovirus infected Insect Cells Human His tag,GST tag 50 μg Log in to see 16 Days
$382.80
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,256.83
Details
HOST_Escherichia coli (E. coli) Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PTPRA Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine) ,
,
Rat (Rattus)

More Proteins for Protein tyrosine Phosphatase, Receptor Type, A (PTPRA) Interaction Partners

Human Protein tyrosine Phosphatase, Receptor Type, A (PTPRA) interaction partners

  1. A receptor type-protein tyrosine phosphatase alpha-Src family kinase-Rap1 pathway was identified as responsible for recruiting myosin IIB to the zonula adherens in epithelial cells and supporting contractile tension.

  2. no evidence was seen for the association of rare, missense mutations in the PTPRA gene with schizophrenia or autism spectrum disorders

  3. Data indicate that scaffold protein (show HOMER1 Proteins) RACK1 (show GNB2L1 Proteins) plays a role in IGF-1 (show IGF1 Proteins)-mediated protein-tyrosine phosphatase alpha (PTPalpha) tyrosine phosphorylation in MCF-7 Cells.

  4. recruited to epithelial adherens junctions for cadherin-dependent cell adhesion and tissue architecture formation

  5. Results suggest that inhibition of PTPalpha can have a beneficial effect on HER2 (show ERBB2 Proteins)-positive breast cancers, but that inhibition of additional targets is needed to block breast tumorigenesis.

  6. new role for PTPalpha in the regulation of motility of mammary epithelial cells in response to ErbB2 (show ERBB2 Proteins) activation.

  7. results suggest that PTPalpha links activation of epidermal growth factor receptor (EGFR (show EGFR Proteins)) signaling with Src (show SRC Proteins) activation and may provide a novel therapeutic target for treatment of breast cancer.

  8. A single-nucleotide polymorphism (rs6138953) on the PTPRA gene in the 20p13 region was found to be associated with elevated fasting glucose level.

  9. The extracellular proteolytic processing is a novel mechanism for PTPalpha regulation.

  10. our results suggest that plasma PTPalpha and fibronectin (show FN1 Proteins) may be associated with opisthorchiasis.

Mouse (Murine) Protein tyrosine Phosphatase, Receptor Type, A (PTPRA) interaction partners

  1. RPTPalpha mediates proinflammatory and proinvasive signaling in rheumatoid arthritis fibroblast-like synoviocytes (FLS), correlating with the promotion of disease in an FLS-dependent model of rheumatoid arthritis.

  2. Ptpra coordinates the regulation of the Fyn (show FYN Proteins) signaling pathway in corpus striatum.

  3. PTPs (show PTS Proteins) alpha and epsilon play distinct roles in osteoclasts.

  4. PTP (show SLC25A3 Proteins)-alpha promotes profibrotic signaling pathways in fibroblasts through control of cellular responsiveness to TGF-beta (show TGFB1 Proteins).

  5. The focal adhesion targeting domain of FAK (show PTK2 Proteins) interacts with protein-tyrosine phosphatase-alpha to restrict IL1 (show IL1A Proteins)-induced Ca2 (show CA2 Proteins)+ release, ERK (show EPHB2 Proteins) activation, and MMP-9 (show MMP9 Proteins) expression.

  6. PTPalpha may be involved in the formation of axoglial junctions and ensheathment in small axons during myelination of the spinal cord.

  7. Findings indicate Grb2 (show GRB2 Proteins) as a new FAK (show PTK2 Proteins) activator and in coordinating PTPalpha tyrosine phosphorylation to enable downstream integrin signaling and migration.

  8. Results suggest that inhibition of PTPalpha can have a beneficial effect on HER2 (show ERBB2 Proteins)-positive breast cancers, but that inhibition of additional targets is needed to block breast tumorigenesis.

  9. Inflammation-induced connective tissue degradation involving fibroblasts requires functionally active PTPalpha.

  10. study described a molecular complex of PTPalpha-BCAR3 (show BCAR3 Proteins)-Cas (show CTNND1 Proteins)-Src (show SRC Proteins); this complex forms in response to PTPalpha Tyr789 phosphorylation and mediates Cas (show CTNND1 Proteins) localization to focal adhesions and Cas (show CTNND1 Proteins) downstream signaling to promote cell migration

Zebrafish Protein tyrosine Phosphatase, Receptor Type, A (PTPRA) interaction partners

  1. ptpra protein, zebrafish, signaling is essential for convergence and extension cell movements during gastrulation.

PTPRA Protein Profile

Protein Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported.

Gene names and symbols associated with PTPRA

  • protein tyrosine phosphatase, receptor type, A (PTPRA)
  • protein tyrosine phosphatase, receptor type, A (ptpra)
  • protein tyrosine phosphatase, receptor type, A (Ptpra)
  • HEPTP protein
  • HLPR protein
  • HPTPA protein
  • HPTPalpha protein
  • LRP protein
  • Ptpa protein
  • ptpa-a protein
  • Ptpalpha protein
  • PTPRA protein
  • PTPRL2 protein
  • R-PTP-alpha protein
  • RPTPA protein
  • Rptpalpha protein
  • RPTP[a] protein
  • Rptra protein
  • Rptralpha protein
  • zf-RPTP[a] protein

Protein level used designations for PTPRA

protein tyrosine phosphatase, receptor type, A , receptor-type tyrosine-protein phosphatase alpha-like , Leukocyte common antigen-related peptide (protein tyrosine phosphate) , PTPLCA-related phosphatase , PTPase-alpha , protein tyrosine phosphatase, receptor type, alpha polypeptide , protein-tyrosine phosphatase alpha , receptor-type tyrosine-protein phosphatase alpha , tyrosine phosphatase alpha , LCA-related phosphatase , PTPTY-28 , R-PTP-alpha , protein tyrosine phosphatase alpha , protein tyrosine phosphatase receptor type alpha , protein-tyrosine-phosphatase alpha

GENE ID SPECIES
100066880 Equus caballus
574364 Macaca mulatta
746684 Pan troglodytes
100017832 Monodelphis domestica
100158513 Xenopus (Silurana) tropicalis
100342875 Oryctolagus cuniculus
100373726 Saccoglossus kowalevskii
100404748 Callithrix jacchus
100449130 Pongo abelii
100464070 Ailuropoda melanoleuca
100605844 Nomascus leucogenys
5786 Homo sapiens
19262 Mus musculus
25167 Rattus norvegicus
140818 Danio rerio
394358 Xenopus laevis
396060 Gallus gallus
477176 Canis lupus familiaris
100138017 Bos taurus
100157496 Sus scrofa
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