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The protein encoded by PTPRC is a member of the protein tyrosine phosphatase (PTP) family. Additionally we are shipping CD45 Proteins (32) and CD45 Kits (16) and many more products for this protein.
Showing 10 out of 2286 products:
Cat (Feline) Monoclonal CD45 Primary Antibody for FACS, IHC (fro) - ABIN118214
Ballas, Rasmussen: Lymphokine-activated killer (LAK) cells. IV. Characterization of murine LAK effector subpopulations. in Journal of immunology (Baltimore, Md. : 1950) 1990
Show all 16 references for ABIN118214
Dog (Canine) Monoclonal CD45 Primary Antibody for FACS, IHC (fro) - ABIN118681
Beverley, Merkenschlager, Terry: Phenotypic diversity of the CD45 antigen and its relationship to function. in Immunology. Supplement 1988
Show all 10 references for ABIN118681
Rat (Rattus) Monoclonal CD45 Primary Antibody for FACS, IHC (fro) - ABIN114375
Brouard, Vanhove, Gagne, Neumann, Douillard, Moreau, Cuturi, Soulillou: T cell repertoire alterations of vascularized xenografts. in Journal of immunology (Baltimore, Md. : 1950) 1999
Show all 5 references for ABIN114375
Human Polyclonal CD45 Primary Antibody for EIA, FACS - ABIN357138
Stanton, Boxall, Hirai, Dawes, Tonks, Yasui, Kanaoka, Yuldasheva, Ishiko, Bodmer, Beverley, Tchilian: A high-frequency polymorphism in exon 6 of the CD45 tyrosine phosphatase gene (PTPRC) resulting in altered isoform expression. in Proceedings of the National Academy of Sciences of the United States of America 2003
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Rat (Rattus) Monoclonal CD45 Primary Antibody for FACS, IHC (fro) - ABIN114373
Brown, Williams: Lymphocyte cell surface glycoproteins which bind to soybean and peanut lectins. in Immunology 1982
Show all 3 references for ABIN114373
Rat (Rattus) Monoclonal CD45 Primary Antibody for FACS - ABIN120474
Butcher: A list of monoclonal antibodies specific for alloantigens of the rat. in Journal of immunogenetics 1988
Show all 3 references for ABIN120474
Mouse (Murine) Monoclonal CD45 Primary Antibody for FACS, IHC (fro) - ABIN114222
Bottomly, Luqman, Greenbaum, Carding, West, Pasqualini, Murphy: A monoclonal antibody to murine CD45R distinguishes CD4 T cell populations that produce different cytokines. in European journal of immunology 1989
Show all 2 references for ABIN114222
Mouse (Murine) Monoclonal CD45 Primary Antibody for FACS - ABIN114220
Hathcock, Hirano, Hodes: CD45 expression by murine B cells and T cells: alteration of CD45 isoforms in subpopulations of activated B cells. in Immunologic research 1993
Show all 2 references for ABIN114220
Human Monoclonal CD45 Primary Antibody for FACS - ABIN1106398
Lee, Huang, Chiang, Chiou, Chen, Hsieh, Jiang: Multipotential mesenchymal stem cells from femoral bone marrow near the site of osteonecrosis. in Stem cells (Dayton, Ohio) 2003
PTPRC has become the most replicated genetic biomarker of response to TNF (show TNF Antibodies) inhibitors
CD45RO+ memory T-cells produce IL-17 (show IL17A Antibodies) in patients with atherosclerosis.
Data show the structural basis for, and the potent signaling effects of, local CD45 antigen and kinase segregation.
a CD45+/CD19 (show CD19 Antibodies) - cell population in bone marrow aspirates correlated with the clinical outcome of patients with mantle cell lymphoma.
High CD45 expression is associated with multiple myeloma.
C77G T(reg (show EXTL3 Antibodies)) showed diminished upregulation of activation markers, lower phosphorylation of p56(lck (show LCK Antibodies))(Y505) and a reduced proliferative potential when stimulated with anti-TcR or anti-TcR plus CD28 (show CD28 Antibodies) mAb suggesting decreased responsiveness to activating stimuli. Data suggest that the changes in CD45 isoform combination resulting from the C77G mutation alter the responsiveness
Findings indicate that CD45 antigen(+) and c-Kit (show KIT Antibodies) protein(+) hematopoietic cells were more abundant in muscle than in bone marrow between embryonic 14.5 and 17.5 days.
CD4 (show CD4 Antibodies)+CD45RO+CD25 (show IL2RA Antibodies)-/lowCD127+: CD4 (show CD4 Antibodies)+CD45RO+CD25hiCD127-/low ratio in peripheral blood indicates heart transplant recipients at risk for cardiac allograft vasculopathy.
CD45+ cells were abundant in the stroma of physiologically immature placental villi and decreased as pregnancy progressed.
This study demonstrated that the copy number variations of PTPRC relate to opioid dependence.
Aging induces loss of stemness with concomitant gain of myogenic properties of a pure population of CD34 (show CD34 Antibodies)+/CD45- muscle derived stem cells.
deletion of Pten (show PTEN Antibodies) in CD45-expressing cells induces development of T-cell acute lymphoblastic leukemia and lymphoma, but not other hematologic malignancies
A noncatalytic role for CD45 in regulating tonic, but not antigen-mediated, B-cell antigen receptor (BCR (show BCR Antibodies)) signaling through modulation of the function of the inhibitory coreceptor CD22 (show CD22 Antibodies), was identified.
CD45 ligation specifically reduced Treg motility in an integrin-dependent manner, resulting in enhanced interactions between Tregs and DCs in vivo.
Data (including data from genome-wide mutagenesis studies) suggest that nonsense mutation in Ptprc is a susceptibility trait for herpes simplex encephalitis due to Herpesvirus 1; this effect appears to be mediated by Th1 (show HAND1 Antibodies) cells and the brain stem.
These findings demonstrate a novel role for CD45 on innate immune cells in promoting lymphopenia-induced T cell proliferation and suggest that innate immune cells may communicate with stromal cells to regulate IL-7 (show IL7 Antibodies) production.
Expressing CD45 promoters containing these regions and tethered to green fluorescent protein (GFP) in a primary B-cell differentiation assay and a transplantation model resulted in high levels of GFP in lymphoid, myeloid, and nucleated erythroid cells
identified a novel CD45 phosphorylation event in hematopoietic progenitor cells that correlated with motile response and governed by the chemotactic factor CXCL12 (show CXCL12 Antibodies)
Data indicate that CD45 functions to regulate Pyk2 (show PTK2B Antibodies)/FAK (show PTK2 Antibodies) activity, likely through the activity of Src (show SRC Antibodies) family kinases, which in turn regulates the levels of paxillin (show PXN Antibodies) to modulate macrophage adhesion and migration.
The large ectodomains of CD45 and CD148 modulate their inhibitory effect by enabling their passive, size-based segregation from ligated TCR, supporting the kinetic-segregation model of TCR triggering.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
receptor-type tyrosine-protein phosphatase C
, leukocyte common antigen, CD45
, protein tyrosine phosphatase, receptor type, C
, CD45 antigen
, leukocyte common antigen
, receptor-type tyrosine-protein phosphatase C-like
, T200 glycoprotein
, T200 leukocyte common antigen
, protein tyrosine phosphatase, receptor type, c polypeptide
, lymphocyte antigen 5
, lymphocyte common antigen
, Protein tyrosine phosphatase, receptor-type, c polypeptide
, leucocyte common antigen
, leukocyte common antigen A
, leukocyte common antigen B
, membrane tyrosine phosphatase