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anti-Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 (PTPRN2) Antibodies

The protein encoded by PTPRN2 is a member of the protein tyrosine phosphatase (PTP) family. Additionally we are shipping Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 Proteins (9) and Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PTPRN2 5799 Q92932
PTPRN2 19276 P80560
PTPRN2 29714 Q63475
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Top anti-Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 Antibodies at antibodies-online.com

Showing 10 out of 56 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis in A2058 cell line lysates (35ug/lane) using PTPRN2  Antibody . This demonstrates the PTPRN2 antibody detected the PTPRN2 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from NIH-3T3 cells, using PTPRN2 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB PTPRN2 Antibody (N-term)  western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the PTPRN2 antibody detected the PTPRN2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB Human Pancreas, Islet: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of Phogrin expression in HeLa (A), SP2/0 (B), H9C2 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA   100 μg Log in to see 8 to 10 Days
$405.17
Details
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 11 to 16 Days
$412.86
Details
Human Rabbit Un-conjugated IP, WB Immunoprecipitation of PTPRN2 transfected lysate using anti-PTPRN2 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with PTPRN2 purified MaxPab mouse polyclonal antibody (B01P) . Western Blot analysis of PTPRN2 expression in transfected 293T cell line by PTPRN2 MaxPab polyclonal antibody.Lane 1: PTPRN2 transfected lysate(108.1 KDa).Lane 2: Non-transfected lysate. 100 μL Log in to see 9 Days
$418.57
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged PTPRN2 is 0.1 ng/ml as a capture antibody. Western Blot detection against Immunogen (37.29 KDa) . 100 μg Log in to see 9 Days
$430.00
Details

PTPRN2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,
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Mouse (Murine)


Rat (Rattus)


Top referenced anti-Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 Antibodies

  1. Human Polyclonal PTPRN2 Primary Antibody for EIA, WB - ABIN360752 : Schmidli, Colman, Cui, Yu, Kewming, Jankulovski, Harrison, Pallen, DeAizpurua: Antibodies to the protein tyrosine phosphatases IAR and IA-2 are associated with progression to insulin-dependent diabetes (IDDM) in first-degree relatives at-risk for IDDM. in Autoimmunity 1998 (PubMed)
    Show all 2 references for ABIN360752

  2. Human Polyclonal PTPRN2 Primary Antibody for EIA, WB - ABIN954382 : Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010 (PubMed)
    Show all 2 references for ABIN954382

More Antibodies against Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 Interaction Partners

Human Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 (PTPRN2) interaction partners

  1. Reduction in plasma membrane PI(4,5)P2 abundance by PTPRN2 and PLCbeta1 releases the PI(4,5)P2-binding protein cofilin from its inactive membrane-associated state into the cytoplasm where it mediates actin turnover dynamics.

  2. Data indicate the X-ray structure of the mature ectodomain of mature ectodomain of phogrin/IA-2beta (PTPRN2) (ME phogrin) at pH 7.4 and 4.6.

  3. ProPTPRN2 elicited these effects through direct interaction with TRAF2 (show TRAF2 Antibodies).

  4. While PTPRN2 shares sequence similarity with protein tyrosine phosphatases, this study in rat suggests that this protein instead functions as a membrane bound phosphatidylinositol phosphatase.

  5. The findings in this patient raise the possibility that PTPRN2 may be active during early development of the human brainstem and that its overexpression may cause bilateral Duane retraction syndrome as occurs in patients with homozygous HOXA1 (show HOXA1 Antibodies) mutations.

  6. IA-2beta is involved in insulin (show INS Antibodies) secretion, but despite its importance as a major autoantigen in human type 1 diabetes, it is not required for the development of diabetes in NOD mice.

  7. In mice IA-2beta expressed exclusively in dense core secretory vesicles (DCV) and with fractions rich in synaptic vesicles (SV) of neuroendocrine cells of brain and impairment of conditioned learning.

Mouse (Murine) Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 (PTPRN2) interaction partners

  1. Data show that miRNAs are involved in regulating the expression of the major type 1 diabetes (T1D) autoantigens IA-2 (show PTPRN Antibodies), IA-2beta, and GAD65 (show GAD2 Antibodies) enzyme.

  2. Membrane-proximal ectodomain of phogrin was produced as a recombinant protein and characterized' results showed that it is a properly folded monomeric domain.

  3. IA-2beta is involved in insulin (show INS Antibodies) secretion, but despite its importance as a major autoantigen in human type 1 diabetes, it is not required for the development of diabetes in NOD mice.

  4. phogrin is recycled in Min6 beta-cells

  5. analysis of a tyrosine-targeting motif for endocytosis and recycling of the dense-core vesicle membrane protein phogrin

  6. experiments show that the dense core vesicle proteins IA-2 (show PTPRN Antibodies) and IA-2beta, alone or in combination, are involved in insulin (show INS Antibodies) secretion, but neither alone nor in combination are they required for the development of diabetes in NOD mice

  7. IA-2beta, but not IA-2 (show PTPRN Antibodies), is induced by ghrelin (show GHRL Antibodies) and inhibits glucose-stimulated insulin (show INS Antibodies) secretion

  8. IA-2 (show PTPRN Antibodies) and IA-2beta are dispensable for exocytosis of insulin (show INS Antibodies) granules, but are probably more important for cargo loading and/or stability of dense core vesicles

  9. Phogrin and IA-2 (show PTPRN Antibodies) function as essential regulators of autocrine insulin (show INS Antibodies) action in pancreatic beta-cells.

  10. deletion of IA-2 (show PTPRN Antibodies) and IA-2beta, structural proteins of secretory vesicles and modulators of neuroendocrine secretion, has a profound effect on the circadian system.

Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 (PTPRN2) Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

Gene names and symbols associated with PTPRN2

  • protein tyrosine phosphatase, receptor type, N polypeptide 2 (PTPRN2) antibody
  • protein tyrosine phosphatase, receptor type, N polypeptide 2 (Ptprn2) antibody
  • 4930425H11Rik antibody
  • IA-2beta antibody
  • IA2beta antibody
  • IAR antibody
  • ICAAR antibody
  • mKIAA0387 antibody
  • phogrin antibody
  • Phol antibody
  • PTP-NP antibody
  • PTPRP antibody
  • R-PTP-N2 antibody

Protein level used designations for PTPRN2

IAR/receptor-like protein-tyrosine phosphatase , islet cell autoantigen-related protein , phogrin , protein tyrosine phosphatase receptor pi , receptor-type tyrosine-protein phosphatase N2 , tyrosine phosphatase IA-2 beta , IA-2 beta , PTP IA-2beta , R-PTP-N2 , protein tyrosine phosphatase-NP , PTP NE-6 , PTPNE6 , protein tyrosine phosphatase receptor-type N polypeptide 2 , protein tyrosine phosphatase, receptor-type, N polypeptide 2

GENE ID SPECIES
5799 Homo sapiens
616515 Bos taurus
19276 Mus musculus
29714 Rattus norvegicus
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