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Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1) ELISA Kits

PCMT1 encodes a member of the type II class of protein carboxyl methyltransferase enzymes. Additionally we are shipping Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase Antibodies (50) and Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase Proteins (14) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
PCMT1 5110 P22061
PCMT1 18537  
PCMT1 25604 P22062
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Top Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase ELISA Kits at antibodies-online.com

Showing 6 out of 10 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 13.8 pg/mL 31.25-2000 pg/mL 96 Tests Log in to see 9 to 11 Days
$810.53
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Mouse
  96 Tests Log in to see 11 to 13 Days
$875.60
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Rat
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$875.60
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Cow
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$1,029.60
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Pig
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$1,029.60
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Chicken
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$1,095.60
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More ELISA Kits for Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase Interaction Partners

Human Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1) interaction partners

  1. Strong PIMT expression was a predictive marker of poor prognosis for surgically resected lung adenocarcinoma.

  2. The data of this study indicated that DA-associated PIMT downregulation is an important event contributing to neuronal cell death

  3. ERK2 (show MAPK1 ELISA Kits)-mediated phosphorylation of transcriptional coactivator binding protein PIMT/NCoA6IP (show TGS1 ELISA Kits) at Ser298 augments hepatic gluconeogenesis.

  4. Overexpression of PCMT1 attentuates Mst1 (show MST1 ELISA Kits) kinase activation and its apoptotic effects in response to hypoxia-induced injury in cardiomyocytes.

  5. Data indicate that human PROTEIN ISOASPARTYL METHYLTRANSFERASE (PIMT) can initiate isoAsp conversion to Asp (show ASIP ELISA Kits), and is able to restore Arabidopsis PRH75 (show DDX46 ELISA Kits)'s complex biochemical activity provided isoAsp formation has not led to conformational alterations.

  6. Data show six differentially expressed proteins were identified as HSP70 (show HSP70 ELISA Kits), PPIA (show PPIA ELISA Kits) and alpha-Enolase (show ENO1 ELISA Kits) (up-regulated) S100-A9, PIMT and beta-5 tubulin (show TUBB ELISA Kits) (down-regulated), most of which had been shown to play a potential role in the pathogenesis of atherosclerosis.

  7. The results implied that maternal polymorphisms in PCMT1 might be a potential genetic risk factor for isolated anencephaly in the Chinese population of Lvliang.

  8. Study provides new insight into the molecular mechanisms by which PIMT suppresses the p53 (show TP53 ELISA Kits) activity through carboxyl methylation, and suggests a therapeutic target for cancers.

  9. PIMT may act as a co-activator in ERalpha (show ESR1 ELISA Kits)-mediated transcription of TFF1 (show TFF1 ELISA Kits) through its recruitment to the promoter via interacting with ERalpha (show ESR1 ELISA Kits).

  10. Control of PCMT1 expression by microRNA 15a/16-1 may thus represent a late checkpoint in apoptosis regulation

Mouse (Murine) Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1) interaction partners

  1. Loss of normal CKB (show CHKB ELISA Kits) structure and function contributes to the mechanisms by which isoaspartate accumulation leads to central nervous system dysfunction in the PIMT-Knockout mouse.

  2. PIMT levels may significantly influence the course of age-related central nervous system dysfunction.

  3. ERK2 (show MAPK1 ELISA Kits)-mediated phosphorylation of transcriptional coactivator binding protein PIMT/NCoA6IP (show TGS1 ELISA Kits) at Ser298 augments hepatic gluconeogenesis.

  4. PIMT knockout mice have perturbations in glutamate (show GRIN1 ELISA Kits) metabolism in the brain and die prematurely of epileptic seizures.

  5. synuclein is not a major target of PIMT in vivo

  6. Altered levels of S-adenosylmethionine and S-adenosylhomocysteine in the brains of PCMT1 knockout mice

  7. Recombinant adeno (show ADORA2A ELISA Kits)-PIMT improved the symptoms of PIMT-deficient mice in vivo, but only partially repaired IsoAsp in damaged proteins.

  8. An accumulation of isoaspartyl residues in cells of mice lacking the isoaspartyl repair enzyme PCMT alters the effector function of T lymphocytes leading to autoantibody production.

  9. Pcmt1-/- mice have altered regulation of the insulin (show INS ELISA Kits) pathway, possibly as a compensatory response to altered glucose uptake or metabolism or as an adaptive response to a general accumulation of isoaspartyl protein damage in the brain and other tissues.

  10. Protein L-isoaspartyl methyltransferase (PIMT) catalyzes in vivo racemization of Asp (show C3 ELISA Kits)-25 in mammalian histone H2B, suggesting that PIMT functions in the repair, rather than the metabolic turnover, of isoaspartyl proteins in vivo.

Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1) Antigen Profile

Antigen Summary

This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimer's disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with PCMT1

  • protein-L-isoaspartate (D-aspartate) O-methyltransferase (pcmt1) antibody
  • protein-L-isoaspartate (D-aspartate) O-methyltransferase (PCMT1) antibody
  • protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 (Pcmt1) antibody
  • C79501 antibody
  • PCM antibody
  • PCMT antibody
  • PIMT antibody

Protein level used designations for PCMT1

L-isoaspartyl protein carboxyl methyltransferase , PIMT , protein L-isoaspartyl/D-aspartyl methyltransferase , protein-L-isoaspartate(D-aspartate) O-methyltransferase , protein-beta-aspartate methyltransferase , protein carboxyl-o-methyltransferase , protein carboxyl methyltransferase

GENE ID SPECIES
495685 Xenopus laevis
428607 Gallus gallus
5110 Homo sapiens
476242 Canis lupus familiaris
100502562 Sus scrofa
613854 Bos taurus
100172708 Pongo abelii
18537 Mus musculus
25604 Rattus norvegicus
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