You are viewing an incomplete version of our website. Please click to reload the website as full version.

Protein-O-Mannosyltransferase 1 Proteins (POMT1)

The protein encoded by POMT1 is an O-mannosyltransferase that requires interaction with the product of the POMT2 gene for enzymatic function. Additionally we are shipping Protein-O-Mannosyltransferase 1 Antibodies (41) and Protein-O-Mannosyltransferase 1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
POMT1 10585 Q9Y6A1
POMT1 99011 Q8R2R1
Rat POMT1 POMT1 84430 Q99PR0
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Protein-O-Mannosyltransferase 1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

POMT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Protein-O-Mannosyltransferase 1 (POMT1) Interaction Partners

Human Protein-O-Mannosyltransferase 1 (POMT1) interaction partners

  1. Inhibition of POMT1/2 in human mesencyhmal stem cells , resulted in complete abolishment of chondrogenesis and alterations of adipogenic and osteogenic potential together with a lethal effect during myogenic induction.

  2. Three patients with heterozygous POMT1 mutations showed left ventricular (LV) dilation and/or decrease in myocardial contractile force.

  3. the effects of replacing Arg(64), Glu (show DCTN1 Proteins)(78) and Arg(138)residues in human POMT1 and POMT2 (show POMT2 Proteins) with Ala on complex formation and enzymatic activity were studied.

  4. the function of the gene products is only known for POMT1, POMT2 (show POMT2 Proteins), and POMGnT1 (show POMGNT1 Proteins), all responsible for the O-mannosylglycan biosynthesis

  5. the N-glycosylation of POMT1 and POMT2 (show POMT2 Proteins) is required for maintaining the conformation as well as the activity of the POMT1-POMT2 (show POMT2 Proteins) complex.

  6. Mutations in the O-mannosyltransferase gene POMT1 give rise to the severe neuronal migration disorder Walker-Warburg syndrome

  7. Extracellular matrix and nuclear abnormalities in skeletal muscle of a patient with Walker-Warburg syndrome caused by POMT1 mutation.

  8. active enzyme complex of POMT1 and POMT2 (show POMT2 Proteins) suggests that the regulation of protein O-mannosylation is complex and appears to be required for normal structure and function of alpha-dystroglycan in muscle and brain

  9. The authors report on a patient with Walker-Warburg syndrome and a novel POMT1 mutation. The patient expressed alpha-dystroglycan core protein, but fully glycosylated alpha-DG antibody epitopes were absent, associated with loss of laminin-binding activity

  10. Results indicate that mutations in the protein O-mannosyltransferase 1 gene result in a defect of protein O-mannosylation in Walker-Warburg syndrome patients.

Mouse (Murine) Protein-O-Mannosyltransferase 1 (POMT1) interaction partners

  1. during embryogenesis, Pomt1 is expressed in the neural tube, the developing eye, and the mesenchyme; targeted deletion of Pomt1 results in early embryonic lethality due to defects in the assembly of Reichert's membrane

Protein-O-Mannosyltransferase 1 (POMT1) Protein Profile

Protein Summary

The protein encoded by this gene is an O-mannosyltransferase that requires interaction with the product of the POMT2 gene for enzymatic function. The encoded protein is found in the membrane of the endoplasmic reticulum. Defects in this gene are a cause of Walker-Warburg syndrome (WWS) and limb-girdle muscular dystrophy type 2K (LGMD2K). Several transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with POMT1

  • protein-O-mannosyltransferase 1 (POMT1)
  • protein-O-mannosyltransferase 1 (Pomt1)
  • AI505244 protein
  • LGMD2K protein
  • MDDGA1 protein
  • MDDGB1 protein
  • MDDGC1 protein
  • RT protein

Protein level used designations for POMT1

dolichyl-phosphate-mannose--protein mannosyltransferase 1 , dolichyl-phosphate-mannose-protein mannosyltransferase , protein O-mannosyl-transferase 1 , protein O-mannosyltransferase 1

GENE ID SPECIES
10585 Homo sapiens
617609 Bos taurus
99011 Mus musculus
84430 Rattus norvegicus
608039 Canis lupus familiaris
100525803 Sus scrofa
Selected quality suppliers for Protein-O-Mannosyltransferase 1 Proteins (POMT1)
Did you look for something else?