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Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.. Additionally we are shipping Proteinase 3 Kits (38) and Proteinase 3 Proteins (35) and many more products for this protein.
Showing 10 out of 188 products:
Human Monoclonal PRTN3 Primary Antibody for Func, EIA - ABIN1108720
Csernok, Lüdemann, Gross, Bainton: Ultrastructural localization of proteinase 3, the target antigen of anti-cytoplasmic antibodies circulating in Wegener's granulomatosis. in The American journal of pathology 1990
Show all 6 references for ABIN1108720
Human Polyclonal PRTN3 Primary Antibody for FACS, IHC - ABIN350763
Duke-Cohan, Morimoto, Rocker, Schlossman: A novel form of dipeptidylpeptidase IV found in human serum. Isolation, characterization, and comparison with T lymphocyte membrane dipeptidylpeptidase IV (CD26). in The Journal of biological chemistry 1995
Show all 5 references for ABIN350763
Human Polyclonal PRTN3 Primary Antibody for WB - ABIN350765
Fujinaga, Chernaia, Halenbeck, Koths, James: The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies. in Journal of molecular biology 1996
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Human Polyclonal PRTN3 Primary Antibody for WB - ABIN1881695
Kuhl, Korkmaz, Utecht, Kniepert, Schönermarck, Specks, Jenne: Mapping of conformational epitopes on human proteinase 3, the autoantigen of Wegener's granulomatosis. in Journal of immunology (Baltimore, Md. : 1950) 2010
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Nicotiana tabacum Polyclonal PRTN3 Primary Antibody for WB - ABIN190718
Sticher, Hofsteenge, Neuhaus, Boller, Meins: Posttranslational processing of a new class of hydroxyproline-containing proteins. Prolyl hydroxylation and C-terminal cleavage of tobacco (Nicotiana tabacum) vacuolar chitinase. in Plant physiology 1994
Show all 2 references for ABIN190718
Human Monoclonal PRTN3 Primary Antibody for ELISA, WB - ABIN969498
Kantari, Pederzoli-Ribeil, Amir-Moazami, Gausson-Dorey, Moura, Lecomte, Benhamou, Witko-Sarsat: Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis. in Blood 2007
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Human Monoclonal PRTN3 Primary Antibody for EIA, IHC (fro) - ABIN1108721
Van Der Geld, Limburg, Kallenberg: Characterization of monoclonal antibodies to proteinase 3 (PR3) as candidate tools for epitope mapping of human anti-PR3 autoantibodies. in Clinical and experimental immunology 2000
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Human Polyclonal PRTN3 Primary Antibody for ICC, FACS - ABIN439708
Hao, Wang, Yuan, Chen, Zhao: A pro-inflammatory role of C5L2 in C5a-primed neutrophils for ANCA-induced activation. in PLoS ONE 2013
Human Polyclonal PRTN3 Primary Antibody for ELISA, WB - ABIN4347912
Bae, Kang, Hong, Lee, Choi, Jhun, Kwak, Hong, Kim, Jo, Kim: Contradictory functions (activation/termination) of neutrophil proteinase 3 enzyme (PR3) in interleukin-33 biological activity. in The Journal of biological chemistry 2012
The levels of both NE and PR3 correlated with absolute neutrophil counts and are reduced in type 1 diabetes mellitus patients.
Report prognostic value of proteinase-3-antineutrophil cytoplasmic antibody in patients with idiopathic interstitial pneumonias.
Molecular simulations suggest that PR3 interacts with phosphatidylserine via a small number of amino acids, which engage in long lasting interactions with the lipid heads. As phosphatidylserine is a major component of microvesicles (MVs), this study also examined the consequences of this interaction on MV production and function.
miR (show MLXIP Antibodies)-634 mimics induced a proinflammatory phenotype in monocyte-derived macrophages, with enhanced expression and release of ADAM17 (show ADAM17 Antibodies) and IL-6 (show IL6 Antibodies) in Proteinase-3 ANCA-Associated Vasculitis
The PR3-induced microenvironment facilitated recruitment of inflammatory cells, such as macrophages, plasmacytoid DCs (pDCs), and neutrophils, which were observed in close proximity within granulomatous lesions in the lungs of GPA patients.
ACPA negative rheumatoid arthritis shares the genetic susceptibility loci with ACPA positive disease.
Data suggest that targeting proteinase-3 (PR3) specific effector memory cells, to prevent relapse, and instituting anti IL-17 (show IL17A Antibodies) therapy, or modulating Tregs could be newer forms of therapy for granulomatosis with polyangiitis (GPA (show GYPA Antibodies)).
Anti-PR3 autoantibodies not detected in sera of patients with pulmonary tuberculosis.
these results highlight a potentially important role for proteinase 3 in emphysema.
The data shows that the neutrophil protease PR3 is a direct modulator of human platelets and causes shape change through activation of the Rho/Rho kinase (show ROCK1 Antibodies) and Ca(2 (show CA2 Antibodies)+) signaling pathways.
In different murine models of apoptotic cell injection, the PR3-induced microenvironment instructed pDC-driven Th9/Th2 cell generation.
PR3-ANCA is a promising biomarker in primary sclerosing cholangitis.
Proteinase 3-mediated caspase-3 (show CASP3 Antibodies) activation controls neutrophil spontaneous death
Increased PRTN3 activity was associated with development of autoimmune diabetes mellitus in NOD mice.
Phagocytosis of apoptotic PR3-expressing cells potentiates proinflammatory cytokines in vivo by resident murine peritoneal macrophages.
the dual functions (activation/termination) of PR3 in IL-33 (show IL33 Antibodies) biological activity.
pathogenic effect of proteinase 3-specific antineutrophil cytoplasmic autoantibodies at local sites of inflammation.
Murine and human proteinase 3 complexes have different interaction patterns with peptidic substrates.
PR3 and neutrophil elastase (show ELANE Antibodies) enhance neutrophil-dependent inflammation by eliminating the local antiinflammatory activity of progranulin (show GRN Antibodies). Our results support the use of serine protease (show F2 Antibodies) inhibitors as antiinflammatory agents.
Neutrophil-derived PR3 can proteolyze high-molecular weight kininogen and liberate PR3-kinin, thereby initiating kallikrein (show KLK1 Antibodies)-independent activation of the kinin pathway
Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.
, C-ANCA antigen
, Wegener granulomatosis autoantigen
, azurophil granule protein 7
, leukocyte proteinase 3
, neutrophil proteinase 4
, serine proteinase, neutrophil
, wegener autoantigen