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anti-Proteinase 3 (PRTN3) Antibodies

Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.. Additionally we are shipping Proteinase 3 Kits (33) and Proteinase 3 Proteins (30) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PRTN3 5657 P24158
PRTN3 314615  
PRTN3 19152 Q61096
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Top anti-Proteinase 3 Antibodies at antibodies-online.com

Showing 10 out of 161 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated ELISA, WB Figure 1: Western blot analysis using PRTN3 mouse mAb against PRTN3 (aa28-256) -hIgGFc transfected HEK293 cell lysate (1) . 100 μL Log in to see 3 to 4 Days
$393.80
Details
Human Rabbit Un-conjugated WB PRTN3 Antibody (C-term) (ABIN1881695) western blot analysis in K562 cell line lysates (35 µg/lane). This demonstrates the PRTN3 antibody detected the PRTN3 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Nicotiana tabacum Rabbit Un-conjugated WB 2 mg Log in to see 5 to 6 Days
$467.78
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-PRTN3 AntibodyTitration: 1.0 µg/mL  Positive Control: Fetal Lung 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated Func, EIA, IHC (fro), IHC (p), WB   0.1 mg Log in to see 6 to 8 Days
$544.50
Details
Human Mouse FITC EIA, IHC (fro), WB   0.1 mg Log in to see 6 to 8 Days
$643.50
Details
Human Rabbit Un-conjugated FACS, IHC, WB WB on human PMN (peripheral blood mononuclear cells isolated from buffycoat. Denatured, reduced) using Rabbit antibody to c-terminal region of Pr3 (Wegener autoantigen): whole serum (ABIN350763) at 1: 500 dilution. Blocked with 1% LFDM for 15 minutes at room temperature with shake, primary antibody incubated for 15 minutes at room temperature, washed 3 times with PBST, 5 minutes each. Secondary antibody was also incubated for 15 minutes at room temperature. Human PBMC were isolated and adjusted to 106 cells mL-1. Cells were fixed with 2% formaldehyde for 10 minutes at 37°C. Washed twice with PBS before cytospin the cells onto microscope slides. Cells were blocked with PBS containing 1%BSA for 20 minutes at room temperature (RT). Excess of blocking solution was removed and cells were then incubated with Rabbit antibody to c-terminal region of Pr3 (Wegener autoantigen): whole serum (ABIN350763) for 30 min at RT (diluted 1:100 in the blocking buffer). Washed 3X with PBS and incubated with anti-Rabbit Alexa 586 for further 30 minutes. Washed as before and nuclear counterstained with DAPI. Neutrophils and Monocytes, known to have PR3 are intensely stained by the Rabbit antibody to c-terminal region of Pr3 (Wegener autoantigen): whole serum (ABIN350763). 100 μL Log in to see 7 to 8 Days
$454.67
Details
Human Rabbit Un-conjugated WB WB on human PMN (peripheral blood mononuclear cells isolated from buffycoat. Denatured, reduced) using Rabbit antibody to n-terminal region of Pr3 (Wegener autoantigen): whole serum(ABIN350767) at 1: 500 dilution. Blocked with 1% LFDM for 15 minutes at room temperature with shake, primary antibody incubated for 15 minutes at room temperature, washed 3 times with PBST, 5 minutes each. Secondary antibody was also incubated for 15 minutes at room temperature. 100 μL Log in to see 7 to 8 Days
$454.67
Details
Human Rabbit Un-conjugated WB WB on human PMN (peripheral blood mononuclear cells isolated from buffycoat. Denatured, reduced) using Rabbit antibody to internal region of Pr3 (Wegener autoantigen): whole serum (ABIN350765) at 1: 500 dilution. Blocked with 1% LFDM for 15 minutes at room temperature with shake, primary antibody incubated for 15 minutes at room temperature, washed 3 times with PBS (1x), 5 minutes each. Secondary antibody was also incubated for 15 minutes at room temperature. 100 μL Log in to see 7 to 8 Days
$454.67
Details
Human Mouse Un-conjugated EIA, IHC (fro), WB   0.1 mg Log in to see 6 to 8 Days
$489.50
Details

PRTN3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Proteinase 3 Antibodies

  1. Human Monoclonal PRTN3 Primary Antibody for Func, EIA - ABIN1108720 : Csernok, Lüdemann, Gross, Bainton: Ultrastructural localization of proteinase 3, the target antigen of anti-cytoplasmic antibodies circulating in Wegener's granulomatosis. in The American journal of pathology 1990 (PubMed)
    Show all 6 references for ABIN1108720

  2. Human Polyclonal PRTN3 Primary Antibody for WB - ABIN1881695 : Kuhl, Korkmaz, Utecht, Kniepert, Schönermarck, Specks, Jenne: Mapping of conformational epitopes on human proteinase 3, the autoantigen of Wegener's granulomatosis. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)
    Show all 5 references for ABIN1881695

  3. Human Polyclonal PRTN3 Primary Antibody for FACS, IHC - ABIN350763 : Duke-Cohan, Morimoto, Rocker, Schlossman: A novel form of dipeptidylpeptidase IV found in human serum. Isolation, characterization, and comparison with T lymphocyte membrane dipeptidylpeptidase IV (CD26). in The Journal of biological chemistry 1995 (PubMed)
    Show all 5 references for ABIN350763

  4. Human Polyclonal PRTN3 Primary Antibody for WB - ABIN350765 : Fujinaga, Chernaia, Halenbeck, Koths, James: The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies. in Journal of molecular biology 1996 (PubMed)
    Show all 5 references for ABIN350765

  5. Human Polyclonal PRTN3 Primary Antibody for WB - ABIN350767 : Grimwood, Gordon, Olsen, Terry, Schmutz, Lamerdin, Hellsten, Goodstein, Couronne, Tran-Gyamfi, Aerts, Altherr, Ashworth, Bajorek, Black, Branscomb, Caenepeel, Carrano, Caoile, Chan, Christensen et al.: The DNA sequence and biology of human chromosome 19. ... in Nature 2004 (PubMed)
    Show all 5 references for ABIN350767

  6. Human Monoclonal PRTN3 Primary Antibody for EIA, IHC (fro) - ABIN1108719 : Van Der Geld, Limburg, Kallenberg: Characterization of monoclonal antibodies to proteinase 3 (PR3) as candidate tools for epitope mapping of human anti-PR3 autoantibodies. in Clinical and experimental immunology 2000 (PubMed)
    Show all 2 references for ABIN1108719

  7. Human Monoclonal PRTN3 Primary Antibody for EIA, IHC (fro) - ABIN1108721 : Pederzoli, Kantari, Gausson, Moriceau, Witko-Sarsat: Proteinase-3 induces procaspase-3 activation in the absence of apoptosis: potential role of this compartmentalized activation of membrane-associated procaspase-3 in neutrophils. in Journal of immunology (Baltimore, Md. : 1950) 2005 (PubMed)
    Show all 2 references for ABIN1108721

  8. Human Monoclonal PRTN3 Primary Antibody for ELISA, WB - ABIN969498 : Kantari, Pederzoli-Ribeil, Amir-Moazami, Gausson-Dorey, Moura, Lecomte, Benhamou, Witko-Sarsat: Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis. in Blood 2007 (PubMed)
    Show all 2 references for ABIN969498

  9. Nicotiana tabacum Polyclonal PRTN3 Primary Antibody for WB - ABIN190718 : Sticher, Hofsteenge, Neuhaus, Boller, Meins: Posttranslational processing of a new class of hydroxyproline-containing proteins. Prolyl hydroxylation and C-terminal cleavage of tobacco (Nicotiana tabacum) vacuolar chitinase. in Plant physiology 1994 (PubMed)
    Show all 2 references for ABIN190718

More Antibodies against Proteinase 3 Interaction Partners

Human Proteinase 3 (PRTN3) interaction partners

  1. miR (show MLXIP Antibodies)-634 mimics induced a proinflammatory phenotype in monocyte-derived macrophages, with enhanced expression and release of ADAM17 (show ADAM17 Antibodies) and IL-6 (show IL6 Antibodies) in Proteinase-3 ANCA-Associated Vasculitis

  2. The PR3-induced microenvironment facilitated recruitment of inflammatory cells, such as macrophages, plasmacytoid DCs (pDCs), and neutrophils, which were observed in close proximity within granulomatous lesions in the lungs of GPA patients.

  3. ACPA negative rheumatoid arthritis shares the genetic susceptibility loci with ACPA positive disease.

  4. Data suggest that targeting proteinase-3 (PR3) specific effector memory cells, to prevent relapse, and instituting anti IL-17 (show IL17A Antibodies) therapy, or modulating Tregs could be newer forms of therapy for granulomatosis with polyangiitis (GPA (show GYPA Antibodies)).

  5. Anti-PR3 autoantibodies not detected in sera of patients with pulmonary tuberculosis.

  6. these results highlight a potentially important role for proteinase 3 in emphysema.

  7. The data shows that the neutrophil protease PR3 is a direct modulator of human platelets and causes shape change through activation of the Rho/Rho kinase (show ROCK1 Antibodies) and Ca(2 (show CA2 Antibodies)+) signaling pathways.

  8. These in vivo data provide, for the first time, compelling evidence of the collateral involvement of cathepsin G (show CTSG Antibodies), NE, and proteinase 3 in cigarette smoke-induced tissue damage and emphysema

  9. Proteinase 3-mediated caspase-3 (show CASP3 Antibodies) activation controls neutrophil spontaneous death

  10. Elevated levels of GCF (show GUCY2F Antibodies) proteinase 3 in CP, G-AgP, and gingivitis might suggest that proteinase 3 plays a role during inflammatory periodontal events in host response.

Mouse (Murine) Proteinase 3 (PRTN3) interaction partners

  1. In different murine models of apoptotic cell injection, the PR3-induced microenvironment instructed pDC-driven Th9/Th2 cell generation.

  2. PR3-ANCA is a promising biomarker in primary sclerosing cholangitis.

  3. Proteinase 3-mediated caspase-3 (show CASP3 Antibodies) activation controls neutrophil spontaneous death

  4. Increased PRTN3 activity was associated with development of autoimmune diabetes mellitus in NOD mice.

  5. Phagocytosis of apoptotic PR3-expressing cells potentiates proinflammatory cytokines in vivo by resident murine peritoneal macrophages.

  6. the dual functions (activation/termination) of PR3 in IL-33 (show IL33 Antibodies) biological activity.

  7. pathogenic effect of proteinase 3-specific antineutrophil cytoplasmic autoantibodies at local sites of inflammation.

  8. Murine and human proteinase 3 complexes have different interaction patterns with peptidic substrates.

  9. PR3 and neutrophil elastase (show ELANE Antibodies) enhance neutrophil-dependent inflammation by eliminating the local antiinflammatory activity of progranulin (show GRN Antibodies). Our results support the use of serine protease (show F2 Antibodies) inhibitors as antiinflammatory agents.

  10. Neutrophil-derived PR3 can proteolyze high-molecular weight kininogen and liberate PR3-kinin, thereby initiating kallikrein (show KLK1 Antibodies)-independent activation of the kinin pathway

Proteinase 3 (PRTN3) Antigen Profile

Protein Summary

Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.

Gene names and symbols associated with anti-Proteinase 3 (PRTN3) Antibodies

  • proteinase 3 (prtn3) antibody
  • proteinase 3 (PRTN3) antibody
  • proteinase 3 (Prtn3) antibody
  • ACPA antibody
  • AGP7 antibody
  • C-ANCA antibody
  • CANCA antibody
  • ela2 antibody
  • MBN antibody
  • MBT antibody
  • MGC132250 antibody
  • mPR3 antibody
  • NP-4 antibody
  • NP4 antibody
  • P29 antibody
  • PR-3 antibody
  • PR3 antibody

Protein level used designations for anti-Proteinase 3 (PRTN3) Antibodies

proteinase 3 , C-ANCA antigen , Wegener granulomatosis autoantigen , azurophil granule protein 7 , leukocyte proteinase 3 , myeloblastin , neutrophil proteinase 4 , serine proteinase, neutrophil , wegener autoantigen , PR-3

GENE ID SPECIES
496090 Xenopus laevis
5657 Homo sapiens
314615 Rattus norvegicus
19152 Mus musculus
100298591 Bos taurus
Selected quality suppliers for anti-Proteinase 3 (PRTN3) Antibodies
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