Proteinase 3 Proteins (PRTN3)

Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.. Additionally we are shipping Proteinase 3 Antibodies (202) and Proteinase 3 Kits (43) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PRTN3 5657 P24158
PRTN3 314615  
PRTN3 19152 Q61096
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Top Proteinase 3 Proteins at antibodies-online.com

Showing 10 out of 32 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Human GST tag Proteinase 3 (PRTN3) (AA 28-248), (full length) protein (GST tag) 50 μg Log in to see 13 to 16 Days
$242.00
Details
HOST_Mammalian Cells Human His tag   50 μg Log in to see 4 Days
$385.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$720.00
Details
HOST_HEK-293 Cells Human His tag Validation with Western Blot 10 μg Log in to see 12 to 15 Days
$460.85
Details
HOST_Human Human His tag   10 μg Log in to see 15 to 16 Days
$225.00
Details
HOST_Human Human Un-conjugated 25 μg Log in to see 2 to 3 Days
$285.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
$416.00
Details

PRTN3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, ,
Rat (Rattus)

Mouse (Murine) ,

More Proteins for Proteinase 3 (PRTN3) Interaction Partners

Human Proteinase 3 (PRTN3) interaction partners

  1. unique structural and functional characteristics of PR3 might be key contributors to the systemic inflammation and to the immune dysregulation observed in granulomatosis with polyangiitis.

  2. Our findings demonstrate how RAGE-PR3 interactions between human prostate cancer cells and the bone marrow microenvironment mediate bone metastasis during prostate cancer progression

  3. PRTN3 variants are associated with ANCA-associated vasculitis risk.

  4. Clinical manifestations varied ANCA-associated vasculitis categories, and neither MPO-ANCA nor PR3-ANCA significantly affected relapse of AAV.

  5. Changes in the DNA methylation (show HELLS Proteins) status of the PRTN3 promoter may predict the likelihood of stable remission and explain autoantigen gene regulation

  6. Study shows that MPO (show MPO Proteins) and PRTN3 in neutrophils of Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) patients with active disease have a distinct pattern of histone modifications, which implicates epigenetic mechanisms in regulating expression of autoantigen genes and suggests that the epigenome may be involved in AAV pathogenesis.

  7. The levels of both NE and PR3 correlated with absolute neutrophil counts and are reduced in type 1 diabetes mellitus patients.

  8. Report prognostic value of proteinase-3-antineutrophil cytoplasmic antibody in patients with idiopathic interstitial pneumonias.

  9. Molecular simulations suggest that PR3 interacts with phosphatidylserine via a small number of amino acids, which engage in long lasting interactions with the lipid heads. As phosphatidylserine is a major component of microvesicles (MVs), this study also examined the consequences of this interaction on MV production and function.

  10. miR (show MLXIP Proteins)-634 mimics induced a proinflammatory phenotype in monocyte-derived macrophages, with enhanced expression and release of ADAM17 (show ADAM17 Proteins) and IL-6 (show IL6 Proteins) in Proteinase-3 ANCA-Associated Vasculitis

Mouse (Murine) Proteinase 3 (PRTN3) interaction partners

  1. Results provide evidence that proteinase 3 as a new factor involved in non-alcoholic fatty liver disease and insulin (show INS Proteins) resistance.

  2. In different murine models of apoptotic cell injection, the PR3-induced microenvironment instructed pDC-driven Th9/Th2 cell generation.

  3. PR3-ANCA is a promising biomarker in primary sclerosing cholangitis.

  4. Proteinase 3-mediated caspase-3 (show CASP3 Proteins) activation controls neutrophil spontaneous death

  5. Increased PRTN3 activity was associated with development of autoimmune diabetes mellitus in NOD mice.

  6. Phagocytosis of apoptotic PR3-expressing cells potentiates proinflammatory cytokines in vivo by resident murine peritoneal macrophages.

  7. the dual functions (activation/termination) of PR3 in IL-33 (show IL33 Proteins) biological activity.

  8. pathogenic effect of proteinase 3-specific antineutrophil cytoplasmic autoantibodies at local sites of inflammation.

  9. Murine and human proteinase 3 complexes have different interaction patterns with peptidic substrates.

  10. PR3 and neutrophil elastase (show ELANE Proteins) enhance neutrophil-dependent inflammation by eliminating the local antiinflammatory activity of progranulin (show GRN Proteins). Our results support the use of serine protease (show F2 Proteins) inhibitors as antiinflammatory agents.

Proteinase 3 (PRTN3) Protein Profile

Protein Summary

Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.

Gene names and symbols associated with Proteinase 3 Proteins (PRTN3)

  • proteinase 3 (prtn3)
  • proteinase 3 (PRTN3)
  • proteinase 3 (Prtn3)
  • ACPA protein
  • AGP7 protein
  • C-ANCA protein
  • CANCA protein
  • ela2 protein
  • MBN protein
  • MBT protein
  • MGC132250 protein
  • mPR3 protein
  • NP-4 protein
  • NP4 protein
  • P29 protein
  • PR-3 protein
  • PR3 protein

Protein level used designations for Proteinase 3 Proteins (PRTN3)

proteinase 3 , C-ANCA antigen , Wegener granulomatosis autoantigen , azurophil granule protein 7 , leukocyte proteinase 3 , myeloblastin , neutrophil proteinase 4 , serine proteinase, neutrophil , wegener autoantigen , PR-3

GENE ID SPECIES
496090 Xenopus laevis
5657 Homo sapiens
314615 Rattus norvegicus
19152 Mus musculus
100298591 Bos taurus
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