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Proteoglycan 4 (Megakaryocyte Stimulating Factor, Articular Superficial Zone Protein) Proteins (PRG4)

Plays a role in boundary lubrication within articulating joints. Additionally we are shipping Proteoglycan 4 (Megakaryocyte Stimulating Factor, Articular Superficial Zone Protein) Antibodies (19) and Proteoglycan 4 (Megakaryocyte Stimulating Factor, Articular Superficial Zone Protein) Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PRG4 64748 Q96GM1
PRG4 289104  
PRG4 96875 Q9JM99
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Top Proteoglycan 4 (Megakaryocyte Stimulating Factor, Articular Superficial Zone Protein) Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

PRG4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Rat (Rattus)
Mouse (Murine)

Top referenced Proteoglycan 4 (Megakaryocyte Stimulating Factor, Articular Superficial Zone Protein) Proteins

  1. Human PRG4 Protein expressed in Wheat germ - ABIN1316188 : Liu, Tefft, Roberts, Zhang, Ren, Li, Huang, Zhang, Phillips, Wu: Cardioprotective proteins upregulated in the liver in response to experimental myocardial ischemia. in American journal of physiology. Heart and circulatory physiology 2012 (PubMed)

More Proteins for Proteoglycan 4 (Megakaryocyte Stimulating Factor, Articular Superficial Zone Protein) (PRG4) Interaction Partners

Mouse (Murine) Proteoglycan 4 (Megakaryocyte Stimulating Factor, Articular Superficial Zone Protein) (PRG4) interaction partners

  1. Prg4 is needed for TMJ disc integrity and function and its absence leads to ectopic chondrogenesis and cartilage formation in conjunction with abnormal BMP signaling.

  2. Discs from Prg4 null mice had a significantly smaller mean transverse disc area, with a significantly larger proportion of this area occupied by the nucleus pulposus.

  3. PRG4 is a novel putative ligand for CD44 (show CD44 Proteins) and may control synoviocyte overgrowth in inflammatory arthropathies via a CD44 (show CD44 Proteins)-mediated mechanism.

  4. Prg4-expressing cells at the embryonic joint surface serve as a progenitor population for deeper layers of mature articular cartilage. Prg4 is expressed by superficial chondrocytes in young mice but in deeper regions of articular cartilage in older mice.

  5. findings confirm the importance of lubricin in intrasynovial tendon lubrication.

  6. mechanical motion may induce Prg4 expression in the superficial zone of articular cartilage

  7. changes in synovial fluid proteins and PRG4 concentrations upon joint loading are mediated by cells within the joint, and that these changes may be used as quantitative indicators for the intensity and duration of acute joint loading

  8. Lubricin is transcribed, translated, and expressed by ocular surface epithelia. Lubricin presence significantly reduces friction between the cornea and conjunctiva and its deficiency may play a role in promoting corneal damage.

  9. lubricin has roles in boundary lubrication, and cell survival

  10. Blunted PTH (show PTH Proteins) anabolic responses in adult Prg4 mutant mice are associated with altered biomechanical impact secondary to joint failure.

Proteoglycan 4 (Megakaryocyte Stimulating Factor, Articular Superficial Zone Protein) (PRG4) Protein Profile

Protein Summary

Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface.

Gene names and symbols associated with PRG4

  • lipid phosphate phosphatase-related protein type 2 (LPPR2)
  • proteoglycan 4 (Prg4)
  • proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) (Prg4)
  • CACP protein
  • DOL54 protein
  • JCAP protein
  • lubricin protein
  • MSF protein
  • PRG4 protein
  • SZP protein

Protein level used designations for PRG4

PRG-4 , plasticity related gene 4 , plasticity-related gene 4 protein , proteoglycan 4, (megakaryocyte stimulating factor, articular superficial zone protein, camptodactyly, arthropathy, coxa vara, pericarditis syndrome) , megakaryocyte-stimulating factor , proteoglycan 3 , proteoglycan 4 , superficial zone proteoglycan

GENE ID SPECIES
64748 Homo sapiens
289104 Rattus norvegicus
96875 Mus musculus
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