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The protein encoded by PRG4 is a large proteoglycan specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells. Additionally we are shipping Proteoglycan 4 Kits (19) and Proteoglycan 4 Proteins (2) and many more products for this protein.
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Lubricin/PRG4 gene expression was increased in medial collateral ligaments after 14 weeks of menopause in adult rabbits.
The mRNA expression levels for lubricin/proteoglycan 4 (PRG4) and tissue inhibitor of metalloproteinase-3 (show TIMP3 Antibodies) increase with aging.
PRG4 binds to TLR2 (show TLR2 Antibodies) and TLR4 (show TLR4 Antibodies) and this binding mediates a novel anti-inflammatory role for PRG4.
Cartilage derived from MSCs expressed lubricin protein both in vitro and in vivo
PRG4 is a novel putative ligand for CD44 (show CD44 Antibodies) and may control synoviocyte overgrowth in inflammatory arthropathies via a CD44 (show CD44 Antibodies)-mediated mechanism.
The O-glycomap of lubricin, a novel mucin (show SLC13A2 Antibodies) responsible for joint lubrication, has been identified by site-specific glycopeptide analysis.
Lubricin (Prg4) plays a role in preventing damage to the superficial zone and preservation of chondrocytes. [Review]
5 novel PRG4 mutations and the first case of CACP syndrome resulting from uniparental disomy of chromosome 1.
We speculate that an important role of lubricin in mediating interactions at the cartilage surface is to attach to the cartilage surface and provide a protective coating that maintains the contacting surfaces in a sterically repulsive state.
Lubricin is transcribed, translated, and expressed by ocular surface epithelia. Lubricin presence significantly reduces friction between the cornea and conjunctiva.
The objective was to evaluate the presence and distribution of the lubricating and anti-adhesion glycoprotein (show CD226 Antibodies) lubricin and cells containing the contractile isoform smooth muscle alpha-actin (show ACTA2 Antibodies) (SMA (show SMN1 Antibodies)) in pseudomembranes around loose hip prostheses.
the identification of a novel null mutation in PRG4 confirming the genetic homogeneity of Camptodactyly-arthropathy-coxa vara-pericarditis syndrome .
The important role of PRG4 in reducing friction in the tissues and compartments of the knee/stifle joint.
The role of cell surface glycosaminoglycans (GAGs) during TGF-beta1 (show TGFB1 Antibodies) stimulation of SZP/lubricin/PRG4 in superficial zone articular chondrocytes, was investigated.
Lubricin expression in explant cartilage was also suppressed under hypoxia
SZP production is dependent on the functional cytoskeleton, and Rho GTPases contribute to SZP accumulation by modulating the actions of TGFbeta (show TGFB1 Antibodies).
the combined treatment with TGF-beta1 (show TGFB1 Antibodies) and BMP-7 (show BMP7 Antibodies) or treatment first with TGF-beta1 (show TGFB1 Antibodies) followed by BMP-7 (show BMP7 Antibodies) was more effective than other treatment groups in both chondrogenic differentiation and SZP secretion.
A variety of monomeric PRG4 proteins and a disulfide-bonded dimer/multimer are secreted by chondrocytes in bovine cartilage explants.
proteoglycan 4 expression and chondrocyte phenotype is invluenced by matrix molecules and alginate-embedded zonal chondrocytes and mesenchymal stem cells
These findings suggest a generalized approach which may be used for molecular resurfacing of tissue surfaces with PRG4 and other lubricating biomolecules.
Mesenchymal progenitor cells derived from synovium and infrapatellar fat pad (show DHX40 Antibodies) as a source for superficial zone cartilage tissue engineering: analysis of superficial zone protein/lubricin expression.
In both explant and monolayer cultures, BMP-7 (show BMP7 Antibodies) increased SZP accumulation in a dose- and time-dependent fashion (p < 0.05).
Prg4 is needed for TMJ disc integrity and function and its absence leads to ectopic chondrogenesis and cartilage formation in conjunction with abnormal BMP signaling.
Discs from Prg4 null mice had a significantly smaller mean transverse disc area, with a significantly larger proportion of this area occupied by the nucleus pulposus.
Prg4-expressing cells at the embryonic joint surface serve as a progenitor population for deeper layers of mature articular cartilage. Prg4 is expressed by superficial chondrocytes in young mice but in deeper regions of articular cartilage in older mice.
findings confirm the importance of lubricin in intrasynovial tendon lubrication.
mechanical motion may induce Prg4 expression in the superficial zone of articular cartilage
changes in synovial fluid proteins and PRG4 concentrations upon joint loading are mediated by cells within the joint, and that these changes may be used as quantitative indicators for the intensity and duration of acute joint loading
Lubricin is transcribed, translated, and expressed by ocular surface epithelia. Lubricin presence significantly reduces friction between the cornea and conjunctiva and its deficiency may play a role in promoting corneal damage.
lubricin has roles in boundary lubrication, and cell survival
Blunted PTH (show PTH Antibodies) anabolic responses in adult Prg4 mutant mice are associated with altered biomechanical impact secondary to joint failure.
The protein encoded by this gene is a large proteoglycan specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.
, articular superficial zone protein
, bG174L6.2 (MSF: megakaryocyte stimulating factor )
, megakaryocyte stimulating factor
, megakaryocyte-stimulating factor
, superficial zone proteoglycan
, proteoglycan 4, (megakaryocyte stimulating factor, articular superficial zone protein, camptodactyly, arthropathy, coxa vara, pericarditis syndrome)
, MLL septin-like fusion
, p53-responsive gene 4
, proteoglycan 3