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Plays a role in boundary lubrication within articulating joints. Additionally we are shipping Proteoglycan 4 (Megakaryocyte Stimulating Factor, Articular Superficial Zone Protein) Antibodies (20) and Proteoglycan 4 (Megakaryocyte Stimulating Factor, Articular Superficial Zone Protein) Proteins (6) and many more products for this protein.
Showing 4 out of 7 products:
Human PRG4 ELISA Kit for Sandwich ELISA - ABIN421836
Roffi, Filardo, Assirelli, Cavallo, Cenacchi, Facchini, Grigolo, Kon, Mariani, Pratelli, Pulsatelli, Marcacci: Does platelet-rich plasma freeze-thawing influence growth factor release and their effects on chondrocytes and synoviocytes? in BioMed research international 2014
Show all 2 Pubmed References
Prg4 is needed for TMJ disc integrity and function and its absence leads to ectopic chondrogenesis and cartilage formation in conjunction with abnormal BMP signaling.
Discs from Prg4 null mice had a significantly smaller mean transverse disc area, with a significantly larger proportion of this area occupied by the nucleus pulposus.
PRG4 is a novel putative ligand for CD44 (show CD44 ELISA Kits) and may control synoviocyte overgrowth in inflammatory arthropathies via a CD44 (show CD44 ELISA Kits)-mediated mechanism.
Prg4-expressing cells at the embryonic joint surface serve as a progenitor population for deeper layers of mature articular cartilage. Prg4 is expressed by superficial chondrocytes in young mice but in deeper regions of articular cartilage in older mice.
findings confirm the importance of lubricin in intrasynovial tendon lubrication.
mechanical motion may induce Prg4 expression in the superficial zone of articular cartilage
changes in synovial fluid proteins and PRG4 concentrations upon joint loading are mediated by cells within the joint, and that these changes may be used as quantitative indicators for the intensity and duration of acute joint loading
Lubricin is transcribed, translated, and expressed by ocular surface epithelia. Lubricin presence significantly reduces friction between the cornea and conjunctiva and its deficiency may play a role in promoting corneal damage.
lubricin has roles in boundary lubrication, and cell survival
Blunted PTH (show PTH ELISA Kits) anabolic responses in adult Prg4 mutant mice are associated with altered biomechanical impact secondary to joint failure.
Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface.
, plasticity related gene 4
, plasticity-related gene 4 protein
, proteoglycan 4, (megakaryocyte stimulating factor, articular superficial zone protein, camptodactyly, arthropathy, coxa vara, pericarditis syndrome)
, megakaryocyte-stimulating factor
, proteoglycan 3
, proteoglycan 4
, superficial zone proteoglycan