You are viewing an incomplete version of our website. Please click to reload the website as full version.

Proteolipid Protein 1 Proteins (PLP1)

PLP1 encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. Additionally we are shipping Proteolipid Protein 1 Antibodies (39) and Proteolipid Protein 1 Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PLP1 18823 P60202
PLP1 5354 P60201
Rat PLP1 PLP1 24943 P60203
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online

Top Proteolipid Protein 1 Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.25 mg Log in to see 49 to 54 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.5 mg Log in to see 49 to 54 Days

PLP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,

Top referenced Proteolipid Protein 1 Proteins

  1. Human PLP1 Protein expressed in Wheat germ - ABIN1315455 : Quintana, Farez, Viglietta, Iglesias, Merbl, Izquierdo, Lucas, Basso, Khoury, Lucchinetti, Cohen, Weiner: Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosis. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)

More Proteins for Proteolipid Protein 1 (PLP1) Interaction Partners

Mouse (Murine) Proteolipid Protein 1 (PLP1) interaction partners

  1. while PLP (show C3 Proteins) can co-exist with P0 in peripheral nervous system(PNS) myelin, PLP (show C3 Proteins) cannot replace P0 as the major structural protein of PNS myelin.

  2. Both extracellular and intracellular epitopes of PLP (show C3 Proteins) contribute to the pathogenesis of MP4-induced experimental autoimmune encephalomyelitis already in the setting of intact myelin.

  3. The insertion of native PLP (show C3 Proteins) into Olg mitochondria of animals with PLP1/Plp1 regulates extracellular pH and adenosine triphosphate.

  4. This study shows for the first time that Plp (show C3 Proteins)-null mice exhibit severe early-onset thermal hyperalgesia that is not associated with changes in thermal allodynic behavior.

  5. A novel mechanism sheds light on the immune regulation by which sulfatide-reactive type II natural killer (NK)T cells suppress inflammatory class II histocompatibility-restricted pathogenic CD4 (show CD4 Proteins)+ T cell responses in a T cell-mediated autoimmune disease.

  6. that an early reactive glia response occurs following mutations in the PLP (show C3 Proteins) gene

  7. Result suggest that plp1 plays a role either in the structural integrity of oligodendrocyte progenitor cell processes or in their response to extracellular cues that orient process outgrowth.

  8. PLP (show C3 Proteins) significantly suppresses both models of experimental autoimmune encephalitis (EAE)even when there is some evidence of epitope spreading in the myelin oligodendrocyte (MOG (show MOG Proteins))38-50-induced EAE model.

  9. PLP (show C3 Proteins) contributes to the high cholesterol content of myelin by association and co-transport in the central nervous system.

  10. Olig2 (show OLIG2 Proteins)/Plp (show C3 Proteins)-positive progenitor cells give rise to Bergmann glia in the cerebellum.

Human Proteolipid Protein 1 (PLP1) interaction partners

  1. Identification and functional study of novel PLP1 mutations in Chinese patients with Pelizaeus-Merzbacher disease. We identified PLP1 mutations in seven male patients with PMD.

  2. In major depressive disorder there was a significantly reduced expression of PLP1 mRNA.

  3. Study investigated 17 unrelated Pelizaeus-Merzbacher disease subjects with copy number gains at the PLP1 locus including triplication and quadruplication of specific genomic intervals-16/17 were found to have a duplication-inverted triplication-duplication rearrangement product.

  4. Myelin proteolipid protein is critical to regulating oligodendrocyte progenitor cell migration.

  5. PLP1 splicing mutations may result in a wide variety of disease phenotypes through a combination of multiple molecular pathogenic mechanisms.

  6. this study provides new insight into the genotype-phenotype correlations of patients with PLP1 splice-site mutations.

  7. Insertion of an extra copy of Xq22.2 into 1p36 results in functional duplication of the PLP1 gene in a girl with classical Pelizaeus-Merzbacher disease.

  8. Data strongly suggest that a secondary structure within intron 3 is important for controlling regulation of the PLP1 alternative splice and that patient mutations can cause Pelizaeus-Merzbacher disease by disrupting this structure.

  9. Mutations found in the PLP1 gene are the cause of PMD in around 20% of the patients in this series.

  10. Data suggest transmembrane segment of PLP contains multiple helix-helix interaction motifs that play role in ability of PLP to form dimers/oligomers; alteration of local hydrophobicity affects both helix-helix interaction and segment alpha-helicity.

Proteolipid Protein 1 (PLP1) Protein Profile

Protein Summary

This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.

Gene names and symbols associated with Proteolipid Protein 1 Proteins (PLP1)

  • proteolipid protein 1 (PLP1)
  • proteolipid protein 1 (plp1)
  • myelin proteolipid protein (Tsp_11640)
  • myelin proteolipid protein (plp)
  • proteolipid protein (myelin) 1 (Plp1)
  • proteolipid protein 1 (Plp1)
  • proteolipid protein 1 (plp1-a)
  • DKFZp459O081 protein
  • DKFZp459O113 protein
  • DM20 protein
  • GPM6C protein
  • hld1 protein
  • jimpy protein
  • jp protein
  • mmpl protein
  • msd protein
  • Plp protein
  • PLP/DM20 protein
  • plp1 protein
  • plp1a protein
  • pmd protein
  • rsh protein
  • spg2 protein

Protein level used designations for Proteolipid Protein 1 Proteins (PLP1)

proteolipid protein 1 , proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated) , myelin proteolipid protein , lipophilin , myelin synthesis deficiency , rump shaker , major myelin proteolipid protein , Proteolipid protein (Pelizaeus-Merzbacher disease spastic paraplegia 2 uncomplicated) , Proteolipid protein (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated) , proteolipid protein (myelin) 1 , PLP , proteolipid protein, lipophilin , PLP-A , lipophilin-A , myelin proteolipid protein (PLP) , myelin proteolipid protein A , proteolipid protein 1 a

465785 Pan troglodytes
613099 Xenopus (Silurana) tropicalis
752012 Taeniopygia guttata
100173486 Pongo abelii
100174736 Pongo abelii
10903177 Trichinella spiralis
100136749 Oncorhynchus mykiss
18823 Mus musculus
5354 Homo sapiens
281410 Bos taurus
24943 Rattus norvegicus
396214 Gallus gallus
481002 Canis lupus familiaris
397029 Sus scrofa
100009169 Oryctolagus cuniculus
398334 Xenopus laevis
100220245 Taeniopygia guttata
Selected quality suppliers for Proteolipid Protein 1 Proteins (PLP1)
Did you look for something else?